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D7DAC8

- D7DAC8_STAHD

UniProt

D7DAC8 - D7DAC8_STAHD

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Protein
Nucleoside diphosphate kinase
Gene
ndk, Shell_1639
Organism
Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP By similarityUniRule annotation
Binding sitei59 – 591ATP By similarityUniRule annotation
Binding sitei87 – 871ATP By similarityUniRule annotation
Binding sitei93 – 931ATP By similarityUniRule annotation
Binding sitei104 – 1041ATP By similarityUniRule annotation
Binding sitei114 – 1141ATP By similarityUniRule annotation
Active sitei117 – 1171Pros-phosphohistidine intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. nucleoside diphosphate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CTP biosynthetic process Source: UniProtKB-HAMAP
  2. GTP biosynthetic process Source: UniProtKB-HAMAP
  3. UTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Nucleotide metabolismUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHEL591019:GC4A-1688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinase
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:Shell_1639Imported
OrganismiStaphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)Imported
Taxonomic identifieri591019 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
ProteomesiUP000002573: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224564.
KOiK00940.
OMAiIARFERK.

Family and domain databases

Gene3Di3.30.70.141. 1 hit.
HAMAPiMF_00451. NDP_kinase.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
SUPFAMiSSF54919. SSF54919. 1 hit.
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7DAC8-1 [UniParc]FASTAAdd to Basket

« Hide

MSIERTLVLI KPDGVRRGLI GEIISRFERK GLKIKALKML WLTRDKAEEF    50
YSVHRGKPFF ESLIEFMTSG PIIAMVLEGD MAISVVRKMI GPTDGREAPP 100
GTIRGDYSLS KSQNVVHASD SPESAVREIG VIFKDDEIID W 141
Length:141
Mass (Da):15,834
Last modified:August 10, 2010 - v1
Checksum:i3B6CF06DFD08D8C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002051 Genomic DNA. Translation: ADI32724.1.
RefSeqiWP_013143921.1. NC_014205.1.
YP_003669623.1. NC_014205.1.

Genome annotation databases

EnsemblBacteriaiADI32724; ADI32724; Shell_1639.
GeneIDi9234932.
KEGGishc:Shell_1639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002051 Genomic DNA. Translation: ADI32724.1 .
RefSeqi WP_013143921.1. NC_014205.1.
YP_003669623.1. NC_014205.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI32724 ; ADI32724 ; Shell_1639 .
GeneIDi 9234932.
KEGGi shc:Shell_1639.

Phylogenomic databases

HOGENOMi HOG000224564.
KOi K00940.
OMAi IARFERK.

Enzyme and pathway databases

BioCyci SHEL591019:GC4A-1688-MONOMER.

Family and domain databases

Gene3Di 3.30.70.141. 1 hit.
HAMAPi MF_00451. NDP_kinase.
InterProi IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view ]
Pfami PF00334. NDK. 1 hit.
[Graphical view ]
PRINTSi PR01243. NUCDPKINASE.
SMARTi SM00562. NDK. 1 hit.
[Graphical view ]
SUPFAMi SSF54919. SSF54919. 1 hit.
PROSITEi PS00469. NDP_KINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Staphylothermus hellenicus DSM 12710."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Anderson I.J., Woyke T.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8.

Entry informationi

Entry nameiD7DAC8_STAHD
AccessioniPrimary (citable) accession number: D7DAC8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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