Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11ATPUniRule annotation1
Binding sitei59ATPUniRule annotation1
Binding sitei87ATPUniRule annotation1
Binding sitei93ATPUniRule annotation1
Binding sitei104ATPUniRule annotation1
Binding sitei114ATPUniRule annotation1
Active sitei117Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processNucleotide metabolismUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHEL591019:G1GL0-1650-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:Shell_1639Imported
OrganismiStaphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)Imported
Taxonomic identifieri591019 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000002573 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi591019.Shell_1639

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 140NDKInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04313 Archaea
COG0105 LUCA
HOGENOMiHOG000224564
KOiK00940
OMAiKIVAMKM
OrthoDBiPOG093Z0ECU

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

D7DAC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIERTLVLI KPDGVRRGLI GEIISRFERK GLKIKALKML WLTRDKAEEF
60 70 80 90 100
YSVHRGKPFF ESLIEFMTSG PIIAMVLEGD MAISVVRKMI GPTDGREAPP
110 120 130 140
GTIRGDYSLS KSQNVVHASD SPESAVREIG VIFKDDEIID W
Length:141
Mass (Da):15,834
Last modified:August 10, 2010 - v1
Checksum:i3B6CF06DFD08D8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002051 Genomic DNA Translation: ADI32724.1
RefSeqiWP_013143921.1, NC_014205.1

Genome annotation databases

EnsemblBacteriaiADI32724; ADI32724; Shell_1639
GeneIDi9234932
KEGGishc:Shell_1639

Similar proteinsi

Entry informationi

Entry nameiD7DAC8_STAHD
AccessioniPrimary (citable) accession number: D7DAC8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health