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Protein

DNA ligase

Gene

lig

Organism
Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei276ATPUniRule annotation1
Active sitei278N6-AMP-lysine intermediateUniRule annotation1
Binding sitei283ATPUniRule annotation1
Binding sitei298ATPUniRule annotation1
Binding sitei328ATPUniRule annotation1
Binding sitei368ATPUniRule annotation1
Binding sitei445ATPUniRule annotation1
Binding sitei451ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Shell_1131Imported
OrganismiStaphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)Imported
Taxonomic identifieri591019 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
Proteomesi
  • UP000002573 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi591019.Shell_1131.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 491DNA_LIGASE_A3InterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiSQCPNYD.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7D8Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQQNEQPR YEKDMPFREL ADTFERIEVI TSRTQMTVLL VNLFKKTPPE
60 70 80 90 100
IIDKVVYLLQ GRLWPDWKGL PELGVGEKML VKAIALATQS RESEVESLYK
110 120 130 140 150
SLGDLGKAAE KLKAKYEEKL KKGAMSILAF VPAKKELTVG QVYETLSRVA
160 170 180 190 200
LATGEGSRDI KLKLLAGLLS DASPKEAKYI IRFVEGRLRL GIGDATIMDA
210 220 230 240 250
LAIVYGGGAH ARPIVERAYN LRADLGHIAK ILATQGLEAL KGIKPQVGIP
260 270 280 290 300
IRPMLAERLN NPVEILKKVG GDSFVEYKYD GERAQIHKLG DKIWIYSRRL
310 320 330 340 350
ENITHQYPDV VDYARKYIKA DEAIVEGEIV AYDPDTGELR PFQELMHRKR
360 370 380 390 400
KHDIHIAIKE VPVKVFLFDL LYVDGEDYTL KPLPERRAKL EEIIEQTETF
410 420 430 440 450
QIAEYIRTND PDELEKFFFK AIEDGAEGVM IKALHKNAIY QAGTRGWLWI
460 470 480 490 500
KYKRDYKSEM IDTVDLVIIG AFYGRGRRGG KYGALLMASY NPDKDVFESV
510 520 530 540 550
CKVGSGFKDE DIDKLPEMLK PYIIEHKHPR VVARMKPDIW VTPALVAEII
560 570 580 590 600
GAELTLSPLH TCCLDAIKPG VGISIRFPRF IRWRPDKGPE DATTSQELLE
610
MYKRQLKKLS E
Length:611
Mass (Da):69,402
Last modified:August 10, 2010 - v1
Checksum:iD0B0E2C2548555CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002051 Genomic DNA. Translation: ADI32232.1.
RefSeqiWP_013143430.1. NC_014205.1.

Genome annotation databases

EnsemblBacteriaiADI32232; ADI32232; Shell_1131.
GeneIDi9234420.
KEGGishc:Shell_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002051 Genomic DNA. Translation: ADI32232.1.
RefSeqiWP_013143430.1. NC_014205.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi591019.Shell_1131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI32232; ADI32232; Shell_1131.
GeneIDi9234420.
KEGGishc:Shell_1131.

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiSQCPNYD.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD7D8Y6_STAHD
AccessioniPrimary (citable) accession number: D7D8Y6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.