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D7D8Y6

- D7D8Y6_STAHD

UniProt

D7D8Y6 - D7D8Y6_STAHD

Protein

DNA ligase

Gene

lig

Organism
Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei276 – 2761ATPUniRule annotation
    Active sitei278 – 2781N6-AMP-lysine intermediateUniRule annotation
    Binding sitei283 – 2831ATPUniRule annotation
    Binding sitei298 – 2981ATPUniRule annotation
    Binding sitei328 – 3281ATPUniRule annotation
    Binding sitei368 – 3681ATPUniRule annotation
    Binding sitei445 – 4451ATPUniRule annotation
    Binding sitei451 – 4511ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSHEL591019:GC4A-1151-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Shell_1131Imported
    OrganismiStaphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)Imported
    Taxonomic identifieri591019 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
    ProteomesiUP000002573: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiMVKMLEG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7D8Y6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTQQNEQPR YEKDMPFREL ADTFERIEVI TSRTQMTVLL VNLFKKTPPE    50
    IIDKVVYLLQ GRLWPDWKGL PELGVGEKML VKAIALATQS RESEVESLYK 100
    SLGDLGKAAE KLKAKYEEKL KKGAMSILAF VPAKKELTVG QVYETLSRVA 150
    LATGEGSRDI KLKLLAGLLS DASPKEAKYI IRFVEGRLRL GIGDATIMDA 200
    LAIVYGGGAH ARPIVERAYN LRADLGHIAK ILATQGLEAL KGIKPQVGIP 250
    IRPMLAERLN NPVEILKKVG GDSFVEYKYD GERAQIHKLG DKIWIYSRRL 300
    ENITHQYPDV VDYARKYIKA DEAIVEGEIV AYDPDTGELR PFQELMHRKR 350
    KHDIHIAIKE VPVKVFLFDL LYVDGEDYTL KPLPERRAKL EEIIEQTETF 400
    QIAEYIRTND PDELEKFFFK AIEDGAEGVM IKALHKNAIY QAGTRGWLWI 450
    KYKRDYKSEM IDTVDLVIIG AFYGRGRRGG KYGALLMASY NPDKDVFESV 500
    CKVGSGFKDE DIDKLPEMLK PYIIEHKHPR VVARMKPDIW VTPALVAEII 550
    GAELTLSPLH TCCLDAIKPG VGISIRFPRF IRWRPDKGPE DATTSQELLE 600
    MYKRQLKKLS E 611
    Length:611
    Mass (Da):69,402
    Last modified:August 10, 2010 - v1
    Checksum:iD0B0E2C2548555CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002051 Genomic DNA. Translation: ADI32232.1.
    RefSeqiWP_013143430.1. NC_014205.1.
    YP_003669131.1. NC_014205.1.

    Genome annotation databases

    EnsemblBacteriaiADI32232; ADI32232; Shell_1131.
    GeneIDi9234420.
    KEGGishc:Shell_1131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002051 Genomic DNA. Translation: ADI32232.1 .
    RefSeqi WP_013143430.1. NC_014205.1.
    YP_003669131.1. NC_014205.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI32232 ; ADI32232 ; Shell_1131 .
    GeneIDi 9234420.
    KEGGi shc:Shell_1131.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi MVKMLEG.

    Enzyme and pathway databases

    BioCyci SHEL591019:GC4A-1151-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Staphylothermus hellenicus DSM 12710."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Anderson I.J., Woyke T.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8Imported.

    Entry informationi

    Entry nameiD7D8Y6_STAHD
    AccessioniPrimary (citable) accession number: D7D8Y6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3