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D7D8Y6 (D7D8Y6_STAHD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length611 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2781N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2761ATP By similarity HAMAP-Rule MF_00407
Binding site2831ATP By similarity HAMAP-Rule MF_00407
Binding site2981ATP By similarity HAMAP-Rule MF_00407
Binding site3281ATP By similarity HAMAP-Rule MF_00407
Binding site3681ATP By similarity HAMAP-Rule MF_00407
Binding site4451ATP By similarity HAMAP-Rule MF_00407
Binding site4511ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D7D8Y6 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: D0B0E2C2548555CF

FASTA61169,402
        10         20         30         40         50         60 
MTTQQNEQPR YEKDMPFREL ADTFERIEVI TSRTQMTVLL VNLFKKTPPE IIDKVVYLLQ 

        70         80         90        100        110        120 
GRLWPDWKGL PELGVGEKML VKAIALATQS RESEVESLYK SLGDLGKAAE KLKAKYEEKL 

       130        140        150        160        170        180 
KKGAMSILAF VPAKKELTVG QVYETLSRVA LATGEGSRDI KLKLLAGLLS DASPKEAKYI 

       190        200        210        220        230        240 
IRFVEGRLRL GIGDATIMDA LAIVYGGGAH ARPIVERAYN LRADLGHIAK ILATQGLEAL 

       250        260        270        280        290        300 
KGIKPQVGIP IRPMLAERLN NPVEILKKVG GDSFVEYKYD GERAQIHKLG DKIWIYSRRL 

       310        320        330        340        350        360 
ENITHQYPDV VDYARKYIKA DEAIVEGEIV AYDPDTGELR PFQELMHRKR KHDIHIAIKE 

       370        380        390        400        410        420 
VPVKVFLFDL LYVDGEDYTL KPLPERRAKL EEIIEQTETF QIAEYIRTND PDELEKFFFK 

       430        440        450        460        470        480 
AIEDGAEGVM IKALHKNAIY QAGTRGWLWI KYKRDYKSEM IDTVDLVIIG AFYGRGRRGG 

       490        500        510        520        530        540 
KYGALLMASY NPDKDVFESV CKVGSGFKDE DIDKLPEMLK PYIIEHKHPR VVARMKPDIW 

       550        560        570        580        590        600 
VTPALVAEII GAELTLSPLH TCCLDAIKPG VGISIRFPRF IRWRPDKGPE DATTSQELLE 

       610 
MYKRQLKKLS E 

« Hide

References

[1]"Complete sequence of Staphylothermus hellenicus DSM 12710."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Anderson I.J., Woyke T.
Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002051 Genomic DNA. Translation: ADI32232.1.
RefSeqYP_003669131.1. NC_014205.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI32232; ADI32232; Shell_1131.
GeneID9234420.
KEGGshc:Shell_1131.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK10747.
OMAMVKMLEG.

Enzyme and pathway databases

BioCycSHEL591019:GC4A-1151-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7D8Y6_STAHD
AccessionPrimary (citable) accession number: D7D8Y6
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)