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D7D8Y6

- D7D8Y6_STAHD

UniProt

D7D8Y6 - D7D8Y6_STAHD

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Protein
DNA ligase
Gene
lig, Shell_1131
Organism
Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei276 – 2761ATP By similarityUniRule annotation
Active sitei278 – 2781N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei283 – 2831ATP By similarityUniRule annotation
Binding sitei298 – 2981ATP By similarityUniRule annotation
Binding sitei328 – 3281ATP By similarityUniRule annotation
Binding sitei368 – 3681ATP By similarityUniRule annotation
Binding sitei445 – 4451ATP By similarityUniRule annotation
Binding sitei451 – 4511ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHEL591019:GC4A-1151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Shell_1131Imported
OrganismiStaphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)Imported
Taxonomic identifieri591019 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeStaphylothermus
ProteomesiUP000002573: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7D8Y6-1 [UniParc]FASTAAdd to Basket

« Hide

MTTQQNEQPR YEKDMPFREL ADTFERIEVI TSRTQMTVLL VNLFKKTPPE    50
IIDKVVYLLQ GRLWPDWKGL PELGVGEKML VKAIALATQS RESEVESLYK 100
SLGDLGKAAE KLKAKYEEKL KKGAMSILAF VPAKKELTVG QVYETLSRVA 150
LATGEGSRDI KLKLLAGLLS DASPKEAKYI IRFVEGRLRL GIGDATIMDA 200
LAIVYGGGAH ARPIVERAYN LRADLGHIAK ILATQGLEAL KGIKPQVGIP 250
IRPMLAERLN NPVEILKKVG GDSFVEYKYD GERAQIHKLG DKIWIYSRRL 300
ENITHQYPDV VDYARKYIKA DEAIVEGEIV AYDPDTGELR PFQELMHRKR 350
KHDIHIAIKE VPVKVFLFDL LYVDGEDYTL KPLPERRAKL EEIIEQTETF 400
QIAEYIRTND PDELEKFFFK AIEDGAEGVM IKALHKNAIY QAGTRGWLWI 450
KYKRDYKSEM IDTVDLVIIG AFYGRGRRGG KYGALLMASY NPDKDVFESV 500
CKVGSGFKDE DIDKLPEMLK PYIIEHKHPR VVARMKPDIW VTPALVAEII 550
GAELTLSPLH TCCLDAIKPG VGISIRFPRF IRWRPDKGPE DATTSQELLE 600
MYKRQLKKLS E 611
Length:611
Mass (Da):69,402
Last modified:August 10, 2010 - v1
Checksum:iD0B0E2C2548555CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002051 Genomic DNA. Translation: ADI32232.1.
RefSeqiWP_013143430.1. NC_014205.1.
YP_003669131.1. NC_014205.1.

Genome annotation databases

EnsemblBacteriaiADI32232; ADI32232; Shell_1131.
GeneIDi9234420.
KEGGishc:Shell_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002051 Genomic DNA. Translation: ADI32232.1 .
RefSeqi WP_013143430.1. NC_014205.1.
YP_003669131.1. NC_014205.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI32232 ; ADI32232 ; Shell_1131 .
GeneIDi 9234420.
KEGGi shc:Shell_1131.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci SHEL591019:GC4A-1151-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Staphylothermus hellenicus DSM 12710."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Anderson I.J., Woyke T.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8.

Entry informationi

Entry nameiD7D8Y6_STAHD
AccessioniPrimary (citable) accession number: D7D8Y6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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