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D7CXY7 (D7CXY7_TRURR) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-isopropylmalate synthase HAMAP-Rule MF_01025
EC=2.3.3.13 HAMAP-Rule MF_01025
Alternative name(s):
Alpha-IPM synthase HAMAP-Rule MF_01025
Alpha-isopropylmalate synthase HAMAP-Rule MF_01025
Gene names
Name:leuA HAMAP-Rule MF_01025
Ordered Locus Names:Trad_0207
OrganismTruepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24) [Complete proteome] [HAMAP]
Taxonomic identifier649638 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Trueperaceae › Truepera ›

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) By similarity. SAAS SAAS002034 HAMAP-Rule MF_01025

Catalytic activity

Acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. HAMAP-Rule MF_01025

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. SAAS SAAS002034 HAMAP-Rule MF_01025

Subunit structure

Homotetramer By similarity. SAAS SAAS002034 HAMAP-Rule MF_01025

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. HAMAP-Rule MF_01025

Sequences

Sequence LengthMass (Da)Tools
D7CXY7 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 60725D056015BA22

FASTA51255,106
        10         20         30         40         50         60 
MAYIKIFDTT LRDGEQTPGV TLNTAEKVEI AKQLARLGVD IIEAGFPITS TGDFEAVSRI 

        70         80         90        100        110        120 
AKEVSGPTIC ALARTARADI ERAAQALEGA ERARIHVFTS GSKIHLEHML RKTPEEVIEA 

       130        140        150        160        170        180 
SVESVRLARQ FTGDVEFSAQ DCTRSELAFL YALYGAAIEA GATVINIPDT VGYGMPLEYA 

       190        200        210        220        230        240 
ELIRNIRDNV PGAKEVDIST HCHDDLGLAV ANSLAAIGAG ATQVECTVNG IGERAGNTSL 

       250        260        270        280        290        300 
EEVVMALGTR RDVWGHETGI NTRELYRTSR MVAMYTGVSV PPNKAVVGDN AFAHESGIHQ 

       310        320        330        340        350        360 
DGVIKALETY EIMSAETVGR DAGVLVMGKH SGRRAFRKTL EELGYELDDE KVNVLFKQFK 

       370        380        390        400        410        420 
DLCDRKQKVT SEDIRALIDA ETARVPQTYE LMSVQFQSGT GMIPVATVRL KTDTGIYEEA 

       430        440        450        460        470        480 
ATGDGPVDAV YRALERVAGL PLKLESYEIR SVGSGKDALG EVSIRASQGE RLVHGRGLST 

       490        500        510 
DVIEASAQAY VDVLNKFAAG IGKASAQQVA TP

« Hide

References

[1]"The complete genome of Truepera radiovictris DSM 17093."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ovchinnikova G., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L. expand/collapse author list , Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17093 / CIP 108686 / LMG 22925 / RQ-24.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002049 Genomic DNA. Translation: ADI13347.1.
RefSeqYP_003703890.1. NC_014221.1.

3D structure databases

ProteinModelPortalD7CXY7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI13347; ADI13347; Trad_0207.
GeneID9279177.
KEGGtra:Trad_0207.
PATRIC38297572. VBITruRad72214_0205.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000046859.
KOK01649.

Enzyme and pathway databases

UniPathwayUPA00048; UER00070.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01025. LeuA_type1.
InterProIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005671. LeuA_bact_synth.
IPR000891. PYR_CT.
[Graphical view]
PfamPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMSSF110921. 2-isopropylmalate_synth_dimer. 1 hit.
TIGRFAMsTIGR00973. leuA_bact. 1 hit.
PROSITEPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CXY7_TRURR
AccessionPrimary (citable) accession number: D7CXY7
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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