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D7CR97

- D7CR97_TRURR

UniProt

D7CR97 - D7CR97_TRURR

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Protein
Thymidine kinase
Gene
tdk, Trad_2071
Organism
Truepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptor By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi149 – 1491Zinc By similarityUniRule annotation
Metal bindingi184 – 1841Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238ATP By similarityUniRule annotation
Nucleotide bindingi89 – 924ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTRAD649638:GH4M-2102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Trad_2071Imported
OrganismiTruepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)Imported
Taxonomic identifieri649638 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesTrueperaceaeTruepera
ProteomesiUP000000379: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiTMRKTEE.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CR97-1 [UniParc]FASTAAdd to Basket

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MLFHPFRGGF LELIVGPMFS GKSEELIRRV TRAFIAKQRV QVFKPALDGR    50
YHAQAVASHN GRTLEALAVS DVEEMRAALS EAVQVVAIDE GQFLSAALVG 100
FACDLAESGK RVMIAGLDLD FRAEPFGPMP ELLSRAESVT KLTAVCVRCG 150
APATRTQRLI GGHPAHYDDP VILVGAAEAY EPRCRACHRV PRAERLTPLF 200
AESR 204
Length:204
Mass (Da):22,256
Last modified:August 10, 2010 - v1
Checksum:i26C1C07FC400C42E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002049 Genomic DNA. Translation: ADI15185.1.
RefSeqiWP_013178549.1. NC_014221.1.
YP_003705728.1. NC_014221.1.

Genome annotation databases

EnsemblBacteriaiADI15185; ADI15185; Trad_2071.
GeneIDi9281064.
KEGGitra:Trad_2071.
PATRICi38301290. VBITruRad72214_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002049 Genomic DNA. Translation: ADI15185.1 .
RefSeqi WP_013178549.1. NC_014221.1.
YP_003705728.1. NC_014221.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI15185 ; ADI15185 ; Trad_2071 .
GeneIDi 9281064.
KEGGi tra:Trad_2071.
PATRICi 38301290. VBITruRad72214_2042.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.
OMAi TMRKTEE.

Enzyme and pathway databases

BioCyci TRAD649638:GH4M-2102-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17093 / CIP 108686 / LMG 22925 / RQ-24.

Entry informationi

Entry nameiD7CR97_TRURR
AccessioniPrimary (citable) accession number: D7CR97
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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