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Protein

Thymidine kinase

Gene

tdk

Organism
Truepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Trad_2071Imported
OrganismiTruepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)Imported
Taxonomic identifieri649638 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesTrueperaceaeTruepera
Proteomesi
  • UP000000379 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi649638.Trad_2071.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CR97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHPFRGGF LELIVGPMFS GKSEELIRRV TRAFIAKQRV QVFKPALDGR
60 70 80 90 100
YHAQAVASHN GRTLEALAVS DVEEMRAALS EAVQVVAIDE GQFLSAALVG
110 120 130 140 150
FACDLAESGK RVMIAGLDLD FRAEPFGPMP ELLSRAESVT KLTAVCVRCG
160 170 180 190 200
APATRTQRLI GGHPAHYDDP VILVGAAEAY EPRCRACHRV PRAERLTPLF

AESR
Length:204
Mass (Da):22,256
Last modified:August 10, 2010 - v1
Checksum:i26C1C07FC400C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002049 Genomic DNA. Translation: ADI15185.1.
RefSeqiWP_013178549.1. NC_014221.1.

Genome annotation databases

EnsemblBacteriaiADI15185; ADI15185; Trad_2071.
KEGGitra:Trad_2071.
PATRICi38301290. VBITruRad72214_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002049 Genomic DNA. Translation: ADI15185.1.
RefSeqiWP_013178549.1. NC_014221.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi649638.Trad_2071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI15185; ADI15185; Trad_2071.
KEGGitra:Trad_2071.
PATRICi38301290. VBITruRad72214_2042.

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD7CR97_TRURR
AccessioniPrimary (citable) accession number: D7CR97
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.