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Protein

Thymidine kinase

Gene

tdk

Organism
Truepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi89 – 92ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTRAD649638:G1GKY-2077-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Trad_2071Imported
OrganismiTruepera radiovictrix (strain DSM 17093 / CIP 108686 / LMG 22925 / RQ-24)Imported
Taxonomic identifieri649638 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesTrueperaceaeTruepera
Proteomesi
  • UP000000379 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi649638.Trad_2071

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

D7CR97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHPFRGGF LELIVGPMFS GKSEELIRRV TRAFIAKQRV QVFKPALDGR
60 70 80 90 100
YHAQAVASHN GRTLEALAVS DVEEMRAALS EAVQVVAIDE GQFLSAALVG
110 120 130 140 150
FACDLAESGK RVMIAGLDLD FRAEPFGPMP ELLSRAESVT KLTAVCVRCG
160 170 180 190 200
APATRTQRLI GGHPAHYDDP VILVGAAEAY EPRCRACHRV PRAERLTPLF

AESR
Length:204
Mass (Da):22,256
Last modified:August 10, 2010 - v1
Checksum:i26C1C07FC400C42E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002049 Genomic DNA Translation: ADI15185.1
RefSeqiWP_013178549.1, NC_014221.1

Genome annotation databases

EnsemblBacteriaiADI15185; ADI15185; Trad_2071
KEGGitra:Trad_2071

Similar proteinsi

Entry informationi

Entry nameiD7CR97_TRURR
AccessioniPrimary (citable) accession number: D7CR97
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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