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D7CPP2 (D7CPP2_SYNLT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS006691

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
D7CPP2 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 84E5711E0C620DAF

FASTA81191,825
        10         20         30         40         50         60 
MQASQTKVLP IDIEKEVKRS FLDYSMSVIV SRALPDVRDG LKPVHRRILY AFYEQGMTPE 

        70         80         90        100        110        120 
KPHRKSANLV GLVLGQYHPH GDAAVYDAMV RMAQDFSMRY CLVDGHGNFG SVDGDSPAAM 

       130        140        150        160        170        180 
RYTEARLTAL AVEMLRDIEK DTVDFRPNYD DTRQEPVVLP ARLPNLLING STGIAVGMAT 

       190        200        210        220        230        240 
SIPPHNLTEV VEGLIHLLEN PEATVDELMR YIKGPDFPTA GLIMGTRGMR QAYRTGRGSV 

       250        260        270        280        290        300 
TVRGRCEIEE KKGGRTSIVV TEIPYMVNKA KLVERIAELV KEKKIDGITD LRDESDRRGI 

       310        320        330        340        350        360 
RIVMDIRRDI SPSVILNKLY RNTQLQDNFG ITLLALVDGE PQVLNLKEML NQYLNHRREV 

       370        380        390        400        410        420 
IRRRTEFDLK VARDRLHIVE GLKIALDNLD EVVDIIRNSP DVKTARNNLM SRFDLTEMQA 

       430        440        450        460        470        480 
EAIVEMRLRQ LTGLERNKLE EEYRELVGRI SDLEDILRRP ERVQAIIKED LIDIKTRFGD 

       490        500        510        520        530        540 
KRRTEIREED ASFEAEDLIE EESIVVTLSN RGYIKRQPLS TYRSQRRGGK GVTGTAIRSE 

       550        560        570        580        590        600 
DFATDIFVTT TLSTLLFFTN HGRVYSLKAY QVPEASRQSR GTPVINFLRL NPGEKVNTVI 

       610        620        630        640        650        660 
SVNRFDAGQH LVMATRTGMV KKVPIDEFRQ IRRSGIIAIN LRNQDELVGV QKIYKGDRLV 

       670        680        690        700        710        720 
LVTGRGYSIV FDEGDVRVMG RGAAGVRGIS LEQGDKVIDI DKYKEGADML LVTERGYGKR 

       730        740        750        760        770        780 
TSLQELRLQK RGGKGLKTIQ ISEKTGELVG GKAVFPKEEF VALTGAGFVI RLKVDDVPRQ 

       790        800        810 
KRYSRGVVVM RCEDNDHIVS IARFKSEDEE E 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002048 Genomic DNA. Translation: ADI00814.1.
RefSeqYP_003701379.1. NC_014220.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI00814; ADI00814; Slip_0006.
GeneID9272773.
KEGGslp:Slip_0006.
PATRIC38266334. VBISynLip21176_0007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076279.
KOK02469.
OMAETVDWVP.

Enzyme and pathway databases

BioCycSLIP643648:GHUR-6-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD7CPP2_SYNLT
AccessionPrimary (citable) accession number: D7CPP2
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)