SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

D7CP25

- D7CP25_SYNLT

UniProt

D7CP25 - D7CP25_SYNLT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
ATP-dependent 6-phosphofructokinase
Gene
pfkA, Slip_1702
Organism
Syntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi103 – 1031Magnesium; catalytic By similarityUniRule annotation
Active sitei127 – 1271Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Allosteric activator ADP By similarityUniRule annotation
Binding sitei162 – 1621Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei211 – 2111Allosteric activator ADP By similarityUniRule annotation
Binding sitei222 – 2221Substrate By similarityUniRule annotation
Binding sitei243 – 2431Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732ATP By similarityUniRule annotation
Nucleotide bindingi102 – 1054ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSLIP643648:GHUR-1741-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotation
Ordered Locus Names:Slip_1702Imported
OrganismiSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)Imported
Taxonomic identifieri643648 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophothermus
ProteomesiUP000000378: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 255Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni125 – 1273Substrate binding By similarityUniRule annotation
Regioni169 – 1713Substrate binding By similarityUniRule annotation
Regioni185 – 1873Allosteric activator ADP binding By similarityUniRule annotation
Regioni213 – 2153Allosteric activator ADP binding By similarityUniRule annotation
Regioni249 – 2524Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248870.
KOiK00850.
OMAiAKLERGH.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CP25-1 [UniParc]FASTAAdd to Basket

« Hide

MKKIAILTSG GDAPGMNAAV RAVVRAGIYA GYQVFGVTRG FQGLINGDFV    50
EMTLGSVADI IHRGGTILRT SRCEEFMEEK GRLRGLEALR DAGIQDVIGI 100
GGNGTIRGLY EFSKLGVNTV AIPGSIDNDI PYCDMSIGFD TAVNTVVSAI 150
NRIRDTATAH ERIFIVEVMG RESGHIALTA GLAGGAESIL IPEVPFDLDQ 200
VVERLKQGMK RGKLHSIIVV AEGCCGAYPL AREIQAKTGM DTKVTVLGHT 250
QRGGMPSAMD RNLASRMGKR AVDLIVEGKG NMMTGYQGMK IVDVPLAQVI 300
EGKKDIDLDI CEIARILSI 319
Length:319
Mass (Da):34,048
Last modified:August 10, 2010 - v1
Checksum:iF2891275BA87B060
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002048 Genomic DNA. Translation: ADI02460.1.
RefSeqiYP_003703025.1. NC_014220.1.

Genome annotation databases

EnsemblBacteriaiADI02460; ADI02460; Slip_1702.
GeneIDi9274508.
KEGGislp:Slip_1702.
PATRICi38269916. VBISynLip21176_1762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002048 Genomic DNA. Translation: ADI02460.1 .
RefSeqi YP_003703025.1. NC_014220.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI02460 ; ADI02460 ; Slip_1702 .
GeneIDi 9274508.
KEGGi slp:Slip_1702.
PATRICi 38269916. VBISynLip21176_1762.

Phylogenomic databases

HOGENOMi HOG000248870.
KOi K00850.
OMAi AKLERGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci SLIP643648:GHUR-1741-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12680 / TGB-C1.

Entry informationi

Entry nameiD7CP25_SYNLT
AccessioniPrimary (citable) accession number: D7CP25
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

Similar proteinsi