Skip Header

Contribute Send feedback
Read comments (?) or add your own

D7CL00 (D7CL00_SYNLT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
EC=6.3.5.3 HAMAP-Rule MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP-Rule MF_00420
Gene names
Name:purL HAMAP-Rule MF_00420
Ordered Locus Names:Slip_0601
OrganismSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1) [Complete proteome] [HAMAP] EMBL ADI01385.1
Taxonomic identifier643648 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophothermus ›

Protein attributes

Sequence length734 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00420

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP-Rule MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP-Rule MF_00420
   Cellular componentCytoplasm HAMAP-Rule MF_00420
   LigandATP-binding HAMAP-Rule MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP-Rule MF_00420 EMBL ADI01385.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding100 – 11112ATP By similarity HAMAP-Rule MF_00420

Sequences

Sequence LengthMass (Da)Tools
D7CL00 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 443EF7944C880A85

FASTA73479,605
        10         20         30         40         50         60 
MKDKPVWREM GLTDEEYAQI RNILGREPNY LELGMFAVMW SEHCGYKNSR PVLKLFPTSG 

        70         80         90        100        110        120 
PRVIQGPGEN AGVVDIGDNQ ALVFKIESHN HPSAVEPYQG AATGVGGIVR DIFTMGARPI 

       130        140        150        160        170        180 
AILDSLRFGP IEDERVRYLF SGVVSGIGGY GNCLGIPTVA GEVYFEESYQ GNPLVNAMCV 

       190        200        210        220        230        240 
GLANIDDIAL AVAGEIGSPL MVVGAKTGRD GIHGATFASE ELSEESADKR PSVQVGDPFM 

       250        260        270        280        290        300 
EKLLIEACLE IIREDLVFGM QDLGAAGLTS AVAEMAGKGD RGVEIDVLLV PRREEGMTPY 

       310        320        330        340        350        360 
EVMLSESQER MLICPKPGKE DRIREIFDKW GLDAAVIGRV TGDGIFRVKE GDQVAGEVPV 

       370        380        390        400        410        420 
AGLTKMCPVY YRQAEEPDYY REKKAFDPMS LPEPEDYNLA LKQLLASPNI ANKEWVYTQY 

       430        440        450        460        470        480 
DYQVMINTAI VPGKADAAVM RVKGHKKGVA LTADGNGRMV FLDPFRGGML AVCEAAQNLA 

       490        500        510        520        530        540 
CTGAKPLALT NCLNFGNPEK PHVFWQFEQA VKGMAAAAKE LEIPVVSGNV SFYNETNGEA 

       550        560        570        580        590        600 
IYPTPVVGMV GLIDDIEKRT DMAFKNDDDL ILLIGGIRTE LGGSEYLKVM HRLVAGEVPE 

       610        620        630        640        650        660 
VNLVREKALI DFLLAVIRSG WVNSCHDISD GGLAVALAEG AITGGLGFTV QLDPEWRPDA 

       670        680        690        700        710        720 
VLFSEAPGRA VITISWLHFD DVLAAAKSHG VEARVMGKVG GDRLLFRKGQ REVINLGVEE 

       730 
AAALWEGAIR CFMS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002048 Genomic DNA. Translation: ADI01385.1.
RefSeqYP_003701950.1. NC_014220.1.

3D structure databases

ProteinModelPortalD7CL00.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI01385; ADI01385; Slip_0601.
GeneID9273381.
KEGGslp:Slip_0601.
PATRIC38267596. VBISynLip21176_0626.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000238227.
KOK01952.
OMAWSEHCCY.

Enzyme and pathway databases

BioCycSLIP643648:GHUR-614-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD7CL00_SYNLT
AccessionPrimary (citable) accession number: D7CL00
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info