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D7CKR0

- D7CKR0_SYNLT

UniProt

D7CKR0 - D7CKR0_SYNLT

Protein

Isocitrate dehydrogenase [NADP]

Gene

Slip_0511

Organism
Syntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSLIP643648:GHUR-524-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Slip_0511Imported
    OrganismiSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)Imported
    Taxonomic identifieri643648 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophothermus
    ProteomesiUP000000378: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD7CKR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7CKR0-1 [UniParc]FASTAAdd to Basket

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    MVEGEKIRVV NGALQVPDNP IIPFIIGDGT GPDIWAAASR VLEAAVERAY    50
    QGKKKIVWKE ILAGEKAFNL IGQWLPQETI DTIREYVIAI KGPLTTPIGG 100
    GIRSLNVALR QELDLYACVR PVRYFKGVPS PVKRPEDTDM VIFRENTEDI 150
    YAGIEWPKGS EEVKKVIRFL KDEMGVKNIR FPETSAIGIK PISEEGSKRL 200
    VRAAIRYALS EGRKSVTLVH KGNIMKFTEG GFKNWGYEVA EQEFGDHVFT 250
    WNQYDEIKER KGEKAANEAQ AEAEAQGKLI VKDVIADIFL QQILTRPREF 300
    DVIATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAV FEATHGTAPK 350
    YAGLDKVNPS SVLLSGEMML RHLGWHEAAD LIIGAVERTI ASKIVTYDFA 400
    RLMEGATEVK CSEFGDALIQ NL 422
    Length:422
    Mass (Da):46,586
    Last modified:August 10, 2010 - v1
    Checksum:iE3ADE64D62C6BCEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002048 Genomic DNA. Translation: ADI01295.1.
    RefSeqiWP_013174697.1. NC_014220.1.
    YP_003701860.1. NC_014220.1.

    Genome annotation databases

    EnsemblBacteriaiADI01295; ADI01295; Slip_0511.
    GeneIDi9273291.
    KEGGislp:Slip_0511.
    PATRICi38267406. VBISynLip21176_0531.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002048 Genomic DNA. Translation: ADI01295.1 .
    RefSeqi WP_013174697.1. NC_014220.1.
    YP_003701860.1. NC_014220.1.

    3D structure databases

    ProteinModelPortali D7CKR0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI01295 ; ADI01295 ; Slip_0511 .
    GeneIDi 9273291.
    KEGGi slp:Slip_0511.
    PATRICi 38267406. VBISynLip21176_0531.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci SLIP643648:GHUR-524-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 12680 / TGB-C1Imported.

    Entry informationi

    Entry nameiD7CKR0_SYNLT
    AccessioniPrimary (citable) accession number: D7CKR0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3