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Protein

Isocitrate dehydrogenase [NADP]

Gene

Slip_0511

Organism
Syntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSLIP643648:GHUR-524-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Slip_0511Imported
OrganismiSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)Imported
Taxonomic identifieri643648 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophothermus
ProteomesiUP000000378 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7CKR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CKR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEGEKIRVV NGALQVPDNP IIPFIIGDGT GPDIWAAASR VLEAAVERAY
60 70 80 90 100
QGKKKIVWKE ILAGEKAFNL IGQWLPQETI DTIREYVIAI KGPLTTPIGG
110 120 130 140 150
GIRSLNVALR QELDLYACVR PVRYFKGVPS PVKRPEDTDM VIFRENTEDI
160 170 180 190 200
YAGIEWPKGS EEVKKVIRFL KDEMGVKNIR FPETSAIGIK PISEEGSKRL
210 220 230 240 250
VRAAIRYALS EGRKSVTLVH KGNIMKFTEG GFKNWGYEVA EQEFGDHVFT
260 270 280 290 300
WNQYDEIKER KGEKAANEAQ AEAEAQGKLI VKDVIADIFL QQILTRPREF
310 320 330 340 350
DVIATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAV FEATHGTAPK
360 370 380 390 400
YAGLDKVNPS SVLLSGEMML RHLGWHEAAD LIIGAVERTI ASKIVTYDFA
410 420
RLMEGATEVK CSEFGDALIQ NL
Length:422
Mass (Da):46,586
Last modified:August 9, 2010 - v1
Checksum:iE3ADE64D62C6BCEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002048 Genomic DNA. Translation: ADI01295.1.
RefSeqiYP_003701860.1. NC_014220.1.

Genome annotation databases

EnsemblBacteriaiADI01295; ADI01295; Slip_0511.
KEGGislp:Slip_0511.
PATRICi38267406. VBISynLip21176_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002048 Genomic DNA. Translation: ADI01295.1.
RefSeqiYP_003701860.1. NC_014220.1.

3D structure databases

ProteinModelPortaliD7CKR0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI01295; ADI01295; Slip_0511.
KEGGislp:Slip_0511.
PATRICi38267406. VBISynLip21176_0531.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.

Enzyme and pathway databases

BioCyciSLIP643648:GHUR-524-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12680 / TGB-C1Imported.

Entry informationi

Entry nameiD7CKR0_SYNLT
AccessioniPrimary (citable) accession number: D7CKR0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 9, 2010
Last sequence update: August 9, 2010
Last modified: March 31, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.