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D7CKR0 (D7CKR0_SYNLT) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Slip_0511 EMBL ADI01295.1
OrganismSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1) [Complete proteome] [HAMAP] EMBL ADI01295.1
Taxonomic identifier643648 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophothermus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
D7CKR0 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: E3ADE64D62C6BCEB

FASTA42246,586
        10         20         30         40         50         60 
MVEGEKIRVV NGALQVPDNP IIPFIIGDGT GPDIWAAASR VLEAAVERAY QGKKKIVWKE 

        70         80         90        100        110        120 
ILAGEKAFNL IGQWLPQETI DTIREYVIAI KGPLTTPIGG GIRSLNVALR QELDLYACVR 

       130        140        150        160        170        180 
PVRYFKGVPS PVKRPEDTDM VIFRENTEDI YAGIEWPKGS EEVKKVIRFL KDEMGVKNIR 

       190        200        210        220        230        240 
FPETSAIGIK PISEEGSKRL VRAAIRYALS EGRKSVTLVH KGNIMKFTEG GFKNWGYEVA 

       250        260        270        280        290        300 
EQEFGDHVFT WNQYDEIKER KGEKAANEAQ AEAEAQGKLI VKDVIADIFL QQILTRPREF 

       310        320        330        340        350        360 
DVIATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAV FEATHGTAPK YAGLDKVNPS 

       370        380        390        400        410        420 
SVLLSGEMML RHLGWHEAAD LIIGAVERTI ASKIVTYDFA RLMEGATEVK CSEFGDALIQ 


NL 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002048 Genomic DNA. Translation: ADI01295.1.
RefSeqYP_003701860.1. NC_014220.1.

3D structure databases

ProteinModelPortalD7CKR0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI01295; ADI01295; Slip_0511.
GeneID9273291.
KEGGslp:Slip_0511.
PATRIC38267406. VBISynLip21176_0531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000021113.
KOK00031.
OMACLRPIRY.

Enzyme and pathway databases

BioCycSLIP643648:GHUR-524-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CKR0_SYNLT
AccessionPrimary (citable) accession number: D7CKR0
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)