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D7CKR0

- D7CKR0_SYNLT

UniProt

D7CKR0 - D7CKR0_SYNLT

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Slip_0511

Organism
Syntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSLIP643648:GHUR-524-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Slip_0511Imported
OrganismiSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1)Imported
Taxonomic identifieri643648 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesSyntrophomonadaceaeSyntrophothermus
ProteomesiUP000000378: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7CKR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CKR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEGEKIRVV NGALQVPDNP IIPFIIGDGT GPDIWAAASR VLEAAVERAY
60 70 80 90 100
QGKKKIVWKE ILAGEKAFNL IGQWLPQETI DTIREYVIAI KGPLTTPIGG
110 120 130 140 150
GIRSLNVALR QELDLYACVR PVRYFKGVPS PVKRPEDTDM VIFRENTEDI
160 170 180 190 200
YAGIEWPKGS EEVKKVIRFL KDEMGVKNIR FPETSAIGIK PISEEGSKRL
210 220 230 240 250
VRAAIRYALS EGRKSVTLVH KGNIMKFTEG GFKNWGYEVA EQEFGDHVFT
260 270 280 290 300
WNQYDEIKER KGEKAANEAQ AEAEAQGKLI VKDVIADIFL QQILTRPREF
310 320 330 340 350
DVIATMNLNG DYISDALAAQ VGGIGIAPGA NINYDTGHAV FEATHGTAPK
360 370 380 390 400
YAGLDKVNPS SVLLSGEMML RHLGWHEAAD LIIGAVERTI ASKIVTYDFA
410 420
RLMEGATEVK CSEFGDALIQ NL
Length:422
Mass (Da):46,586
Last modified:August 10, 2010 - v1
Checksum:iE3ADE64D62C6BCEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002048 Genomic DNA. Translation: ADI01295.1.
RefSeqiWP_013174697.1. NC_014220.1.
YP_003701860.1. NC_014220.1.

Genome annotation databases

EnsemblBacteriaiADI01295; ADI01295; Slip_0511.
GeneIDi9273291.
KEGGislp:Slip_0511.
PATRICi38267406. VBISynLip21176_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002048 Genomic DNA. Translation: ADI01295.1 .
RefSeqi WP_013174697.1. NC_014220.1.
YP_003701860.1. NC_014220.1.

3D structure databases

ProteinModelPortali D7CKR0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI01295 ; ADI01295 ; Slip_0511 .
GeneIDi 9273291.
KEGGi slp:Slip_0511.
PATRICi 38267406. VBISynLip21176_0531.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.

Enzyme and pathway databases

BioCyci SLIP643648:GHUR-524-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 12680 / TGB-C1Imported.

Entry informationi

Entry nameiD7CKR0_SYNLT
AccessioniPrimary (citable) accession number: D7CKR0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 1, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3