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D7CIR3 (D7CIR3_SYNLT) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458
EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH HAMAP-Rule MF_01458
Ordered Locus Names:Slip_0128
OrganismSyntrophothermus lipocalidus (strain DSM 12680 / TGB-C1) [Complete proteome] [HAMAP] EMBL ADI00928.1
Taxonomic identifier643648 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Syntrophomonadaceae › Syntrophothermus ›

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cell membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential EMBL ADI00928.1
Chain27 – 600574 Potential EMBL ADI00928.1
PRO_5000606907

Regions

Topological domain1 – 33Cytoplasmic By similarity HAMAP-Rule MF_01458
Transmembrane4 – 2421Helical; By similarity HAMAP-Rule MF_01458
Topological domain25 – 10379Extracellular By similarity HAMAP-Rule MF_01458
Transmembrane104 – 12421Helical; By similarity HAMAP-Rule MF_01458
Topological domain125 – 600476Cytoplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding197 – 2048ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4201 By similarity HAMAP-Rule MF_01458
Metal binding4191Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4231Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4951Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
D7CIR3 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 5BB03355020F79F0

FASTA60066,553
        10         20         30         40         50         60 
MDRVLKNFAI YAVIVLLAVF AIKATSESEK PTQDVDYSTF YRDVAQDKID QVMITVDTDV 

        70         80         90        100        110        120 
YIIEGKYKDG KTFRTEAPKE DNIFEHLRAH NVAYDTEKAK GPPWWTGLLS TLLPIAILVG 

       130        140        150        160        170        180 
FIFLMMNQTQ GGGNRVMQFG RSRARMTTPE EVKVTFKDVA GADEAKEELQ EVIEFLKNPQ 

       190        200        210        220        230        240 
KFIQMGAKIP KGVLLYGPPG TGKTLMARAV AGEAGVPFFS ISGSDFVEMF VGVGAARVRD 

       250        260        270        280        290        300 
LFENAKKNAP CIVFIDEIDA VGRQRGAGVG GGHDEREQTL NQLLVEMDGF STNEGIIVMA 

       310        320        330        340        350        360 
GTNRPDILDP ALLRPGRFDR HIVIDRPDVK GREAILKVHA EGKPLAPGVD MSVIAKRTPG 

       370        380        390        400        410        420 
FTGADLANVM NEAALLSARR NKKEITMEEL EDAIERVIAG PEKKSRVISE KEKRLVAYHE 

       430        440        450        460        470        480 
AGHAVVSYFL PNTDKVHKIS IIPRGRAGGY TLLLPEEDIN YVTKSRLLDE VTTLLGGRVA 

       490        500        510        520        530        540 
ESLVLQEVST GAQNDLERAT SIVRRMITEY GMSEELGPLT FGHKREEVFL GRDIARDRNY 

       550        560        570        580        590        600 
SEAIAYAIDQ EARGFIENCY EKAKDILTQN IDKLHKVAEK LMEKEVLEGD EFEAIMTGRA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002048 Genomic DNA. Translation: ADI00928.1.
RefSeqYP_003701493.1. NC_014220.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSM41.021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI00928; ADI00928; Slip_0128.
GeneID9272905.
KEGGslp:Slip_0128.
PATRIC38266626. VBISynLip21176_0144.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000217276.
KOK03798.
OMAFLDQQPQ.

Enzyme and pathway databases

BioCycSLIP643648:GHUR-138-MONOMER.

Family and domain databases

HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CIR3_SYNLT
AccessionPrimary (citable) accession number: D7CIR3
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info