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D7CCR7 (D7CCR7_STRBB) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan 2,3-dioxygenase HAMAP-Rule MF_01972

Short name=TDO HAMAP-Rule MF_01972
EC=1.13.11.11 HAMAP-Rule MF_01972
Alternative name(s):
Tryptamin 2,3-dioxygenase HAMAP-Rule MF_01972
Tryptophan oxygenase HAMAP-Rule MF_01972
Tryptophan pyrrolase HAMAP-Rule MF_01972
Tryptophanase HAMAP-Rule MF_01972
Gene names
Name:tdo EMBL ADI08798.1
Synonyms:kynA HAMAP-Rule MF_01972
Ordered Locus Names:SBI_05678 EMBL ADI08798.1
OrganismStreptomyces bingchenggensis (strain BCW-1) [Complete proteome] [HAMAP] EMBL ADI08798.1
Taxonomic identifier749414 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity. HAMAP-Rule MF_01972

Catalytic activity

L-tryptophan + O2 = N-formyl-L-kynurenine. HAMAP-Rule MF_01972

Cofactor

Binds 2 heme groups per tetramer By similarity. HAMAP-Rule MF_01972

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. HAMAP-Rule MF_01972

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01972

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family. HAMAP-Rule MF_01972

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2381Iron (heme axial ligand) By similarity HAMAP-Rule MF_01972
Binding site1161Substrate By similarity HAMAP-Rule MF_01972
Binding site1231Heme By similarity HAMAP-Rule MF_01972
Binding site2521Substrate By similarity HAMAP-Rule MF_01972

Sequences

Sequence LengthMass (Da)Tools
D7CCR7 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 055168D4364F2952

FASTA28031,295
        10         20         30         40         50         60 
MSHQPAPHEA EPDTPNLDFQ GTTPYEDYVQ ASVLTHLQHP LSDDPGEMVF LVTTQVMELW 

        70         80         90        100        110        120 
FTVIVHEWQT AAQALREDDL PTALAALKRS TYELESLNAS WKPLAHLTPG QFNSYRSALG 

       130        140        150        160        170        180 
EGSGFQSAMY RRMEFLLGEK SASMLVPHRG APRVHGELEK ALTEPSLYDE VLGYLARQGY 

       190        200        210        220        230        240 
AVPESVLDRD PTRRYEPDAA VERVWQEIYS GPDDTAPARL GEALTEVAEL VWRWRNDHLV 

       250        260        270        280 
ATRRAMGAKA GTGGSAGVAW LEKRATKNVF PELWTARSHV 

« Hide

References

[1]"Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BCW-1 EMBL ADI08798.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002047 Genomic DNA. Translation: ADI08798.1.
RefSeqYP_004963929.1. NC_016582.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI08798; ADI08798; SBI_05678.
GeneID11609549.
KEGGsbh:SBI_05678.
PATRIC43269364. VBIStrBin158249_5863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000221583.
KOK00453.
OMAFQSAMYR.

Enzyme and pathway databases

BioCycSBIN749414:GHKA-5721-MONOMER.
UniPathwayUPA00333; UER00453.

Family and domain databases

HAMAPMF_01972. T23O.
InterProIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERPTHR10138. PTHR10138. 1 hit.
PfamPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CCR7_STRBB
AccessionPrimary (citable) accession number: D7CCR7
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)