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D7CCR7

- D7CCR7_STRBB

UniProt

D7CCR7 - D7CCR7_STRBB

Protein

Tryptophan 2,3-dioxygenase

Gene

tdo

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

    Catalytic activityi

    L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

    Cofactori

    Binds 2 heme groups per tetramer.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei123 – 1231HemeUniRule annotation
    Metal bindingi238 – 2381Iron (heme axial ligand)UniRule annotation
    Binding sitei252 – 2521SubstrateUniRule annotation

    GO - Molecular functioni

    1. heme binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. tryptophan 2,3-dioxygenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophan catabolic process to kynurenine Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DioxygenaseUniRule annotationImported, Oxidoreductase

    Keywords - Biological processi

    Tryptophan catabolismUniRule annotation

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSBIN749414:GHKA-5721-MONOMER.
    UniPathwayiUPA00333; UER00453.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
    Short name:
    TDOUniRule annotation
    Alternative name(s):
    Tryptamin 2,3-dioxygenaseUniRule annotation
    Tryptophan oxygenaseUniRule annotation
    Tryptophan pyrrolaseUniRule annotation
    TryptophanaseUniRule annotation
    Gene namesi
    Name:tdoImported
    Synonyms:kynAUniRule annotation
    Ordered Locus Names:SBI_05678Imported
    OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
    Taxonomic identifieri749414 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000377: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000221583.
    KOiK00453.
    OMAiFERIYQD.

    Family and domain databases

    HAMAPiMF_01972. T23O.
    InterProiIPR004981. Trp_2_3_dOase.
    [Graphical view]
    PANTHERiPTHR10138. PTHR10138. 1 hit.
    PfamiPF03301. Trp_dioxygenase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7CCR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHQPAPHEA EPDTPNLDFQ GTTPYEDYVQ ASVLTHLQHP LSDDPGEMVF    50
    LVTTQVMELW FTVIVHEWQT AAQALREDDL PTALAALKRS TYELESLNAS 100
    WKPLAHLTPG QFNSYRSALG EGSGFQSAMY RRMEFLLGEK SASMLVPHRG 150
    APRVHGELEK ALTEPSLYDE VLGYLARQGY AVPESVLDRD PTRRYEPDAA 200
    VERVWQEIYS GPDDTAPARL GEALTEVAEL VWRWRNDHLV ATRRAMGAKA 250
    GTGGSAGVAW LEKRATKNVF PELWTARSHV 280
    Length:280
    Mass (Da):31,295
    Last modified:August 10, 2010 - v1
    Checksum:i055168D4364F2952
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI08798.1.
    RefSeqiYP_004963929.1. NC_016582.1.

    Genome annotation databases

    EnsemblBacteriaiADI08798; ADI08798; SBI_05678.
    GeneIDi11609549.
    KEGGisbh:SBI_05678.
    PATRICi43269364. VBIStrBin158249_5863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI08798.1 .
    RefSeqi YP_004963929.1. NC_016582.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI08798 ; ADI08798 ; SBI_05678 .
    GeneIDi 11609549.
    KEGGi sbh:SBI_05678.
    PATRICi 43269364. VBIStrBin158249_5863.

    Phylogenomic databases

    HOGENOMi HOG000221583.
    KOi K00453.
    OMAi FERIYQD.

    Enzyme and pathway databases

    UniPathwayi UPA00333 ; UER00453 .
    BioCyci SBIN749414:GHKA-5721-MONOMER.

    Family and domain databases

    HAMAPi MF_01972. T23O.
    InterProi IPR004981. Trp_2_3_dOase.
    [Graphical view ]
    PANTHERi PTHR10138. PTHR10138. 1 hit.
    Pfami PF03301. Trp_dioxygenase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
      Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
      J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCW-1Imported.

    Entry informationi

    Entry nameiD7CCR7_STRBB
    AccessioniPrimary (citable) accession number: D7CCR7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3