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D7CCR7

- D7CCR7_STRBB

UniProt

D7CCR7 - D7CCR7_STRBB

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Protein

Tryptophan 2,3-dioxygenase

Gene

tdo

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

Binds 2 heme groups per tetramer.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei123 – 1231HemeUniRule annotation
Metal bindingi238 – 2381Iron (heme axial ligand)UniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation

GO - Molecular functioni

  1. heme binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. tryptophan 2,3-dioxygenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan catabolic process to kynurenine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DioxygenaseUniRule annotationImported, Oxidoreductase

Keywords - Biological processi

Tryptophan catabolismUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-5721-MONOMER.
UniPathwayiUPA00333; UER00453.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:tdoImported
Synonyms:kynAUniRule annotation
Ordered Locus Names:SBI_05678Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221583.
KOiK00453.
OMAiFERIYQD.

Family and domain databases

HAMAPiMF_01972. T23O.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CCR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQPAPHEA EPDTPNLDFQ GTTPYEDYVQ ASVLTHLQHP LSDDPGEMVF
60 70 80 90 100
LVTTQVMELW FTVIVHEWQT AAQALREDDL PTALAALKRS TYELESLNAS
110 120 130 140 150
WKPLAHLTPG QFNSYRSALG EGSGFQSAMY RRMEFLLGEK SASMLVPHRG
160 170 180 190 200
APRVHGELEK ALTEPSLYDE VLGYLARQGY AVPESVLDRD PTRRYEPDAA
210 220 230 240 250
VERVWQEIYS GPDDTAPARL GEALTEVAEL VWRWRNDHLV ATRRAMGAKA
260 270 280
GTGGSAGVAW LEKRATKNVF PELWTARSHV
Length:280
Mass (Da):31,295
Last modified:August 10, 2010 - v1
Checksum:i055168D4364F2952
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI08798.1.
RefSeqiWP_014178262.1. NC_016582.1.
YP_004963929.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI08798; ADI08798; SBI_05678.
GeneIDi11609549.
KEGGisbh:SBI_05678.
PATRICi43269364. VBIStrBin158249_5863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI08798.1 .
RefSeqi WP_014178262.1. NC_016582.1.
YP_004963929.1. NC_016582.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI08798 ; ADI08798 ; SBI_05678 .
GeneIDi 11609549.
KEGGi sbh:SBI_05678.
PATRICi 43269364. VBIStrBin158249_5863.

Phylogenomic databases

HOGENOMi HOG000221583.
KOi K00453.
OMAi FERIYQD.

Enzyme and pathway databases

UniPathwayi UPA00333 ; UER00453 .
BioCyci SBIN749414:GHKA-5721-MONOMER.

Family and domain databases

HAMAPi MF_01972. T23O.
InterProi IPR004981. Trp_2_3_dOase.
[Graphical view ]
PANTHERi PTHR10138. PTHR10138. 1 hit.
Pfami PF03301. Trp_dioxygenase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7CCR7_STRBB
AccessioniPrimary (citable) accession number: D7CCR7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3