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Protein

Tryptophan 2,3-dioxygenase

Gene

tdo

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 2 heme groups per tetramer.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei123 – 1231HemeUniRule annotation
Metal bindingi238 – 2381Iron (heme axial ligand)UniRule annotation
Binding sitei252 – 2521SubstrateUniRule annotation

GO - Molecular functioni

  1. heme binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. tryptophan 2,3-dioxygenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan catabolic process to kynurenine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DioxygenaseUniRule annotationImported, Oxidoreductase

Keywords - Biological processi

Tryptophan catabolismUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-5721-MONOMER.
UniPathwayiUPA00333; UER00453.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:tdoImported
Synonyms:kynAUniRule annotation
Ordered Locus Names:SBI_05678Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221583.
KOiK00453.
OMAiFQSAMYR.

Family and domain databases

HAMAPiMF_01972. T23O.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CCR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQPAPHEA EPDTPNLDFQ GTTPYEDYVQ ASVLTHLQHP LSDDPGEMVF
60 70 80 90 100
LVTTQVMELW FTVIVHEWQT AAQALREDDL PTALAALKRS TYELESLNAS
110 120 130 140 150
WKPLAHLTPG QFNSYRSALG EGSGFQSAMY RRMEFLLGEK SASMLVPHRG
160 170 180 190 200
APRVHGELEK ALTEPSLYDE VLGYLARQGY AVPESVLDRD PTRRYEPDAA
210 220 230 240 250
VERVWQEIYS GPDDTAPARL GEALTEVAEL VWRWRNDHLV ATRRAMGAKA
260 270 280
GTGGSAGVAW LEKRATKNVF PELWTARSHV
Length:280
Mass (Da):31,295
Last modified:August 10, 2010 - v1
Checksum:i055168D4364F2952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI08798.1.
RefSeqiWP_014178262.1. NC_016582.1.
YP_004963929.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI08798; ADI08798; SBI_05678.
GeneIDi11609549.
KEGGisbh:SBI_05678.
PATRICi43269364. VBIStrBin158249_5863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI08798.1.
RefSeqiWP_014178262.1. NC_016582.1.
YP_004963929.1. NC_016582.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI08798; ADI08798; SBI_05678.
GeneIDi11609549.
KEGGisbh:SBI_05678.
PATRICi43269364. VBIStrBin158249_5863.

Phylogenomic databases

HOGENOMiHOG000221583.
KOiK00453.
OMAiFQSAMYR.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00453.
BioCyciSBIN749414:GHKA-5721-MONOMER.

Family and domain databases

HAMAPiMF_01972. T23O.
InterProiIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERiPTHR10138. PTHR10138. 1 hit.
PfamiPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7CCR7_STRBB
AccessioniPrimary (citable) accession number: D7CCR7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.