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D7CCB7

- D7CCB7_STRBB

UniProt

D7CCB7 - D7CCB7_STRBB

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei256 – 2561ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSBIN749414:GHKA-3537-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:gltXUniRule annotationImported
    Ordered Locus Names:SBI_03515Imported
    OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
    Taxonomic identifieri749414 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000377: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD7CCB7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi7 – 1711"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi253 – 2575"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252720.
    KOiK01885.
    OMAiPEGMLNY.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_B. Glu_tRNA_synth_B.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D7CCB7-1 [UniParc]FASTAAdd to Basket

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    MRVRFCPSPT GNPHVGLVRT ALFNWAFARH HGGTLVFRIE DTDAARDSEE    50
    SYQQLLDAMR WLGLDWDEGP EIGGPHAPYR QSQRMDLYRD VAERLQESGH 100
    AYRCYCTAEE LEERREEARK AGRPSGYDGK CRTLTAEQRA AYEAEGRSSI 150
    VRFRMPDEPI TFTDLVRGEL TFTPENVTDY GIVRANGAPL YTLVNPVDDA 200
    LMEITHVLRG EDLLSSTPRQ IALYRALAEI GVGGGTVPAF GHLPYVMGEG 250
    NKKLSKRDPQ ASLNLYRERG FLPEGLLNYL SLLGWSLAPD RDVFSMDELV 300
    AAFDIAQVNA NPARFDLKKA EAINADHIRQ LDVKAFIEAC GPWLKAPHAP 350
    WAPEAFDSAA FEALAPLAQT RLTVLSDITA NVDFLFLDEP VEDEASWTKA 400
    MKPGADALLA SVRTRLAEAE WDAETLKAAV LAAGEEHGLK LGKAQAPVRV 450
    AVTGRTVGLP LFESLEVLGR ERTLARVDAA LAKLTA 486
    Length:486
    Mass (Da):53,642
    Last modified:August 10, 2010 - v1
    Checksum:i531FEC8977AD4A47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI06636.1.
    RefSeqiWP_014176110.1. NC_016582.1.
    YP_004961767.1. NC_016582.1.

    Genome annotation databases

    EnsemblBacteriaiADI06636; ADI06636; SBI_03515.
    GeneIDi11613976.
    KEGGisbh:SBI_03515.
    PATRICi43264892. VBIStrBin158249_3647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI06636.1 .
    RefSeqi WP_014176110.1. NC_016582.1.
    YP_004961767.1. NC_016582.1.

    3D structure databases

    ProteinModelPortali D7CCB7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI06636 ; ADI06636 ; SBI_03515 .
    GeneIDi 11613976.
    KEGGi sbh:SBI_03515.
    PATRICi 43264892. VBIStrBin158249_3647.

    Phylogenomic databases

    HOGENOMi HOG000252720.
    KOi K01885.
    OMAi PEGMLNY.

    Enzyme and pathway databases

    BioCyci SBIN749414:GHKA-3537-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    1.10.1160.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_B. Glu_tRNA_synth_B.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR004527. Glu-tRNA-ligase_bac/mito.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
      Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
      J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCW-1Imported.

    Entry informationi

    Entry nameiD7CCB7_STRBB
    AccessioniPrimary (citable) accession number: D7CCB7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3