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D7CCB7

- D7CCB7_STRBB

UniProt

D7CCB7 - D7CCB7_STRBB

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Protein
Glutamate--tRNA ligase
Gene
gltX, SBI_03515
Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei256 – 2561ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-3537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase
Gene namesi
Name:gltXUniRule annotationImported
Ordered Locus Names:SBI_03515Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7CCB7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi7 – 1711"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi253 – 2575"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000252720.
KOiK01885.
OMAiPEGMLNY.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

D7CCB7-1 [UniParc]FASTAAdd to Basket

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MRVRFCPSPT GNPHVGLVRT ALFNWAFARH HGGTLVFRIE DTDAARDSEE    50
SYQQLLDAMR WLGLDWDEGP EIGGPHAPYR QSQRMDLYRD VAERLQESGH 100
AYRCYCTAEE LEERREEARK AGRPSGYDGK CRTLTAEQRA AYEAEGRSSI 150
VRFRMPDEPI TFTDLVRGEL TFTPENVTDY GIVRANGAPL YTLVNPVDDA 200
LMEITHVLRG EDLLSSTPRQ IALYRALAEI GVGGGTVPAF GHLPYVMGEG 250
NKKLSKRDPQ ASLNLYRERG FLPEGLLNYL SLLGWSLAPD RDVFSMDELV 300
AAFDIAQVNA NPARFDLKKA EAINADHIRQ LDVKAFIEAC GPWLKAPHAP 350
WAPEAFDSAA FEALAPLAQT RLTVLSDITA NVDFLFLDEP VEDEASWTKA 400
MKPGADALLA SVRTRLAEAE WDAETLKAAV LAAGEEHGLK LGKAQAPVRV 450
AVTGRTVGLP LFESLEVLGR ERTLARVDAA LAKLTA 486
Length:486
Mass (Da):53,642
Last modified:August 10, 2010 - v1
Checksum:i531FEC8977AD4A47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI06636.1.
RefSeqiWP_014176110.1. NC_016582.1.
YP_004961767.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI06636; ADI06636; SBI_03515.
GeneIDi11613976.
KEGGisbh:SBI_03515.
PATRICi43264892. VBIStrBin158249_3647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI06636.1 .
RefSeqi WP_014176110.1. NC_016582.1.
YP_004961767.1. NC_016582.1.

3D structure databases

ProteinModelPortali D7CCB7.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI06636 ; ADI06636 ; SBI_03515 .
GeneIDi 11613976.
KEGGi sbh:SBI_03515.
PATRICi 43264892. VBIStrBin158249_3647.

Phylogenomic databases

HOGENOMi HOG000252720.
KOi K01885.
OMAi PEGMLNY.

Enzyme and pathway databases

BioCyci SBIN749414:GHKA-3537-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7CCB7_STRBB
AccessioniPrimary (citable) accession number: D7CCB7
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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