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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
Ordered Locus Names:SBI_03515Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000377 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi749414.SBI_03515

Structurei

3D structure databases

ProteinModelPortaliD7CCB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 319tRNA-synt_1cInterPro annotationAdd BLAST318

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili409 – 429Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 17"HIGH" regionUniRule annotationAdd BLAST11
Motifi253 – 257"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

D7CCB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRFCPSPT GNPHVGLVRT ALFNWAFARH HGGTLVFRIE DTDAARDSEE
60 70 80 90 100
SYQQLLDAMR WLGLDWDEGP EIGGPHAPYR QSQRMDLYRD VAERLQESGH
110 120 130 140 150
AYRCYCTAEE LEERREEARK AGRPSGYDGK CRTLTAEQRA AYEAEGRSSI
160 170 180 190 200
VRFRMPDEPI TFTDLVRGEL TFTPENVTDY GIVRANGAPL YTLVNPVDDA
210 220 230 240 250
LMEITHVLRG EDLLSSTPRQ IALYRALAEI GVGGGTVPAF GHLPYVMGEG
260 270 280 290 300
NKKLSKRDPQ ASLNLYRERG FLPEGLLNYL SLLGWSLAPD RDVFSMDELV
310 320 330 340 350
AAFDIAQVNA NPARFDLKKA EAINADHIRQ LDVKAFIEAC GPWLKAPHAP
360 370 380 390 400
WAPEAFDSAA FEALAPLAQT RLTVLSDITA NVDFLFLDEP VEDEASWTKA
410 420 430 440 450
MKPGADALLA SVRTRLAEAE WDAETLKAAV LAAGEEHGLK LGKAQAPVRV
460 470 480
AVTGRTVGLP LFESLEVLGR ERTLARVDAA LAKLTA
Length:486
Mass (Da):53,642
Last modified:August 10, 2010 - v1
Checksum:i531FEC8977AD4A47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA Translation: ADI06636.1

Genome annotation databases

EnsemblBacteriaiADI06636; ADI06636; SBI_03515
KEGGisbh:SBI_03515
PATRICifig|749414.3.peg.3647

Similar proteinsi

Entry informationi

Entry nameiD7CCB7_STRBB
AccessioniPrimary (citable) accession number: D7CCB7
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health