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D7CCA5 (D7CCA5_STRBB) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL ADI06624.1
Ordered Locus Names:SBI_03503 EMBL ADI06624.1
OrganismStreptomyces bingchenggensis (strain BCW-1) [Complete proteome] [HAMAP] EMBL ADI06624.1
Taxonomic identifier749414 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain170 – 380211ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding206 – 26156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3341Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3471Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3471Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3491Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D7CCA5 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 28F4F62FB507AABC

FASTA39042,171
        10         20         30         40         50         60 
MSSQSPAPSP VPPPSGGEPR KLRVAVVFGG RSSEHTISVV TAGAVLRAID REKYDVLPIG 

        70         80         90        100        110        120 
ITGDGRWALT ADEPDRMAIA GRVLPSVEGL AESEDGSVLL PVEQGNREVV YAEPGAVPKA 

       130        140        150        160        170        180 
LGEVDVVFPM LHGPYGEDGT LQGLLELSGV PYVGAGVLAS AVGMDKEYMK RVFVSFGLPV 

       190        200        210        220        230        240 
GPYEVIRPRE WEKDPAAARK KIVEFAGEHG WPVFVKPARA GSSIGISKVD DISGLEEAIE 

       250        260        270        280        290        300 
EARRHDPKIV VEALLRGREI ECGVLEFEDG PRASVPAEIP PVSTHDFYDF EAKYIDSADG 

       310        320        330        340        350        360 
VVPAPLTEEQ TERVRELAVR AFEAASCEGL VRADFFLLDS GEFVINEINT MPGFTPISMY 

       370        380        390 
PRMWQESGVS YPELVDRLIQ AALRRPTGLR 

« Hide

References

[1]"Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BCW-1 EMBL ADI06624.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002047 Genomic DNA. Translation: ADI06624.1.
RefSeqYP_004961755.1. NC_016582.1.

3D structure databases

ProteinModelPortalD7CCA5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI06624; ADI06624; SBI_03503.
GeneID11613959.
KEGGsbh:SBI_03503.
PATRIC43264858. VBIStrBin158249_3635.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.

Enzyme and pathway databases

BioCycSBIN749414:GHKA-3520-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CCA5_STRBB
AccessionPrimary (citable) accession number: D7CCA5
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)