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Protein

Probable DNA ligase

Gene

ligB

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei208ATPUniRule annotation1
Active sitei210N6-AMP-lysine intermediateUniRule annotation1
Binding sitei215ATPUniRule annotation1
Binding sitei230ATPUniRule annotation1
Binding sitei259ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei377ATPUniRule annotation1
Binding sitei383ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:G1GKW-5502-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:SBI_05488Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000377 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi749414.SBI_05488

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini299 – 417DNA_LIGASE_A3InterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D7CAP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAEVARTS REVAATSARS EKIAALARLL SRVEPAEAPV VITYLAGRLP
60 70 80 90 100
QRRIGVGWAG LRVRPEPAAG PRLGVLDVHQ ALDRVAAVSG TGATTERKRL
110 120 130 140 150
VSGLMSAATE DEQAFLFGLI GGELRQGALD ALAVEGLSAA VGAPPAEVRR
160 170 180 190 200
AVMLGGSLGA VAQALLENGP PALSEFGLEV GRPVLPMLAH SARDLDEALD
210 220 230 240 250
RLGPCAVEEK LDGIRVQVHR DKETVRVYTR TLDEITDRLP EVVAAARELA
260 270 280 290 300
VERAVLDGEV IALDADGRPR PFQEISGRVG ARLDVAGASA SLPLYPVFFD
310 320 330 340 350
LLAVDDRDLL DLSARDRHAE LARVAPAPRR VRRLVAEDPR DEATRRAARE
360 370 380 390 400
FAADVLARGH EGVMAKSLDA PYSAGRRGAC WLKVKPVHTL DLVVLAAEWG
410 420 430 440 450
HGRRTGKLSN LHLGARRPDG TYAMLGKTFK GLTDKQLGWQ TEALLRLAVS
460 470 480 490 500
DDGWVVRVRP ELVVEVAFDS LQRSSRYPEG VTLRFARVLR YREDKPAEEA
510
DTVETVLALR DA
Length:512
Mass (Da):55,292
Last modified:August 10, 2010 - v1
Checksum:i580406D4FD5B206D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA Translation: ADI08608.1
RefSeqiWP_014178072.1, NC_016582.1

Genome annotation databases

EnsemblBacteriaiADI08608; ADI08608; SBI_05488
KEGGisbh:SBI_05488
PATRICifig|749414.3.peg.5667

Similar proteinsi

Entry informationi

Entry nameiD7CAP1_STRBB
AccessioniPrimary (citable) accession number: D7CAP1
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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