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D7CAP1

- D7CAP1_STRBB

UniProt

D7CAP1 - D7CAP1_STRBB

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Protein
Probable DNA ligase
Gene
ligB, lig, SBI_05488
Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATP By similarityUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei215 – 2151ATP By similarityUniRule annotation
Binding sitei230 – 2301ATP By similarityUniRule annotation
Binding sitei259 – 2591ATP By similarityUniRule annotation
Binding sitei299 – 2991ATP By similarityUniRule annotation
Binding sitei377 – 3771ATP By similarityUniRule annotation
Binding sitei383 – 3831ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-5530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:SBI_05488Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7CAP1-1 [UniParc]FASTAAdd to Basket

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MLLAEVARTS REVAATSARS EKIAALARLL SRVEPAEAPV VITYLAGRLP    50
QRRIGVGWAG LRVRPEPAAG PRLGVLDVHQ ALDRVAAVSG TGATTERKRL 100
VSGLMSAATE DEQAFLFGLI GGELRQGALD ALAVEGLSAA VGAPPAEVRR 150
AVMLGGSLGA VAQALLENGP PALSEFGLEV GRPVLPMLAH SARDLDEALD 200
RLGPCAVEEK LDGIRVQVHR DKETVRVYTR TLDEITDRLP EVVAAARELA 250
VERAVLDGEV IALDADGRPR PFQEISGRVG ARLDVAGASA SLPLYPVFFD 300
LLAVDDRDLL DLSARDRHAE LARVAPAPRR VRRLVAEDPR DEATRRAARE 350
FAADVLARGH EGVMAKSLDA PYSAGRRGAC WLKVKPVHTL DLVVLAAEWG 400
HGRRTGKLSN LHLGARRPDG TYAMLGKTFK GLTDKQLGWQ TEALLRLAVS 450
DDGWVVRVRP ELVVEVAFDS LQRSSRYPEG VTLRFARVLR YREDKPAEEA 500
DTVETVLALR DA 512
Length:512
Mass (Da):55,292
Last modified:August 10, 2010 - v1
Checksum:i580406D4FD5B206D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI08608.1.
RefSeqiYP_004963739.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI08608; ADI08608; SBI_05488.
GeneIDi11609358.
KEGGisbh:SBI_05488.
PATRICi43268972. VBIStrBin158249_5667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI08608.1 .
RefSeqi YP_004963739.1. NC_016582.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI08608 ; ADI08608 ; SBI_05488 .
GeneIDi 11609358.
KEGGi sbh:SBI_05488.
PATRICi 43268972. VBIStrBin158249_5667.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.

Enzyme and pathway databases

BioCyci SBIN749414:GHKA-5530-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7CAP1_STRBB
AccessioniPrimary (citable) accession number: D7CAP1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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