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D7CAP1 (D7CAP1_STRBB) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:ligB EMBL ADI08608.1
Synonyms:lig HAMAP-Rule MF_00407
Ordered Locus Names:SBI_05488 EMBL ADI08608.1
OrganismStreptomyces bingchenggensis (strain BCW-1) [Complete proteome] [HAMAP] EMBL ADI08608.1
Taxonomic identifier749414 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2101N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2081ATP By similarity HAMAP-Rule MF_00407
Binding site2151ATP By similarity HAMAP-Rule MF_00407
Binding site2301ATP By similarity HAMAP-Rule MF_00407
Binding site2591ATP By similarity HAMAP-Rule MF_00407
Binding site2991ATP By similarity HAMAP-Rule MF_00407
Binding site3771ATP By similarity HAMAP-Rule MF_00407
Binding site3831ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D7CAP1 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 580406D4FD5B206D

FASTA51255,292
        10         20         30         40         50         60 
MLLAEVARTS REVAATSARS EKIAALARLL SRVEPAEAPV VITYLAGRLP QRRIGVGWAG 

        70         80         90        100        110        120 
LRVRPEPAAG PRLGVLDVHQ ALDRVAAVSG TGATTERKRL VSGLMSAATE DEQAFLFGLI 

       130        140        150        160        170        180 
GGELRQGALD ALAVEGLSAA VGAPPAEVRR AVMLGGSLGA VAQALLENGP PALSEFGLEV 

       190        200        210        220        230        240 
GRPVLPMLAH SARDLDEALD RLGPCAVEEK LDGIRVQVHR DKETVRVYTR TLDEITDRLP 

       250        260        270        280        290        300 
EVVAAARELA VERAVLDGEV IALDADGRPR PFQEISGRVG ARLDVAGASA SLPLYPVFFD 

       310        320        330        340        350        360 
LLAVDDRDLL DLSARDRHAE LARVAPAPRR VRRLVAEDPR DEATRRAARE FAADVLARGH 

       370        380        390        400        410        420 
EGVMAKSLDA PYSAGRRGAC WLKVKPVHTL DLVVLAAEWG HGRRTGKLSN LHLGARRPDG 

       430        440        450        460        470        480 
TYAMLGKTFK GLTDKQLGWQ TEALLRLAVS DDGWVVRVRP ELVVEVAFDS LQRSSRYPEG 

       490        500        510 
VTLRFARVLR YREDKPAEEA DTVETVLALR DA 

« Hide

References

[1]"Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BCW-1 EMBL ADI08608.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002047 Genomic DNA. Translation: ADI08608.1.
RefSeqYP_004963739.1. NC_016582.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI08608; ADI08608; SBI_05488.
GeneID11609358.
KEGGsbh:SBI_05488.
PATRIC43268972. VBIStrBin158249_5667.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK01971.
OMAVPIVIPY.

Enzyme and pathway databases

BioCycSBIN749414:GHKA-5530-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7CAP1_STRBB
AccessionPrimary (citable) accession number: D7CAP1
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)