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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi86 – 89ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:G1GKW-3276-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SBI_03277Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000377 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi749414.SBI_03277

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiRATHNAR
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

D7C8K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELVFFSGT MDCGKSTLAL QIEHNRSARG LQGMIYTRDD RAGRGKLSSR
60 70 80 90 100
LGLVTEAVEA GDDLDFYAHV VGILTAGGRA DYVIVDEAQF LAPSQIDQLA
110 120 130 140 150
RVVDDLGLDV FAFGITTDFR SKLFPGSQRL VELADRIEVL QVEALCWCGA
160 170 180 190 200
RATHNARTVG GEMVVEGAQV VVGDVNQPGA EVGYEVLCRR HHRRRMTAAA
210 220 230
ARAATLSPDV LPVDPAAAPA PVPHQAQTPR TAP
Length:233
Mass (Da):25,003
Last modified:August 10, 2010 - v1
Checksum:i7332DB8445E1DC16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA Translation: ADI06398.1
RefSeqiWP_014175875.1, NC_016582.1

Genome annotation databases

EnsemblBacteriaiADI06398; ADI06398; SBI_03277
KEGGisbh:SBI_03277
PATRICifig|749414.3.peg.3395

Similar proteinsi

Entry informationi

Entry nameiD7C8K9_STRBB
AccessioniPrimary (citable) accession number: D7C8K9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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