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D7C8K9

- D7C8K9_STRBB

UniProt

D7C8K9 - D7C8K9_STRBB

Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi86 – 894ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSBIN749414:GHKA-3290-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:SBI_03277Imported
    OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
    Taxonomic identifieri749414 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000377: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiHYSTMNA.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D7C8K9-1 [UniParc]FASTAAdd to Basket

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    MPELVFFSGT MDCGKSTLAL QIEHNRSARG LQGMIYTRDD RAGRGKLSSR    50
    LGLVTEAVEA GDDLDFYAHV VGILTAGGRA DYVIVDEAQF LAPSQIDQLA 100
    RVVDDLGLDV FAFGITTDFR SKLFPGSQRL VELADRIEVL QVEALCWCGA 150
    RATHNARTVG GEMVVEGAQV VVGDVNQPGA EVGYEVLCRR HHRRRMTAAA 200
    ARAATLSPDV LPVDPAAAPA PVPHQAQTPR TAP 233
    Length:233
    Mass (Da):25,003
    Last modified:August 10, 2010 - v1
    Checksum:i7332DB8445E1DC16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI06398.1.
    RefSeqiWP_014175875.1. NC_016582.1.
    YP_004961529.1. NC_016582.1.

    Genome annotation databases

    EnsemblBacteriaiADI06398; ADI06398; SBI_03277.
    GeneIDi11612431.
    KEGGisbh:SBI_03277.
    PATRICi43264378. VBIStrBin158249_3395.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002047 Genomic DNA. Translation: ADI06398.1 .
    RefSeqi WP_014175875.1. NC_016582.1.
    YP_004961529.1. NC_016582.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI06398 ; ADI06398 ; SBI_03277 .
    GeneIDi 11612431.
    KEGGi sbh:SBI_03277.
    PATRICi 43264378. VBIStrBin158249_3395.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi HYSTMNA.

    Enzyme and pathway databases

    BioCyci SBIN749414:GHKA-3290-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
      Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
      J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCW-1Imported.

    Entry informationi

    Entry nameiD7C8K9_STRBB
    AccessioniPrimary (citable) accession number: D7C8K9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3