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D7C8K9

- D7C8K9_STRBB

UniProt

D7C8K9 - D7C8K9_STRBB

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Protein

Thymidine kinase

Gene
tdk, SBI_03277
Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi86 – 894ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-3290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SBI_03277Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiHYSTMNA.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D7C8K9-1 [UniParc]FASTAAdd to Basket

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MPELVFFSGT MDCGKSTLAL QIEHNRSARG LQGMIYTRDD RAGRGKLSSR    50
LGLVTEAVEA GDDLDFYAHV VGILTAGGRA DYVIVDEAQF LAPSQIDQLA 100
RVVDDLGLDV FAFGITTDFR SKLFPGSQRL VELADRIEVL QVEALCWCGA 150
RATHNARTVG GEMVVEGAQV VVGDVNQPGA EVGYEVLCRR HHRRRMTAAA 200
ARAATLSPDV LPVDPAAAPA PVPHQAQTPR TAP 233
Length:233
Mass (Da):25,003
Last modified:August 10, 2010 - v1
Checksum:i7332DB8445E1DC16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI06398.1.
RefSeqiWP_014175875.1. NC_016582.1.
YP_004961529.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI06398; ADI06398; SBI_03277.
GeneIDi11612431.
KEGGisbh:SBI_03277.
PATRICi43264378. VBIStrBin158249_3395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002047 Genomic DNA. Translation: ADI06398.1 .
RefSeqi WP_014175875.1. NC_016582.1.
YP_004961529.1. NC_016582.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI06398 ; ADI06398 ; SBI_03277 .
GeneIDi 11612431.
KEGGi sbh:SBI_03277.
PATRICi 43264378. VBIStrBin158249_3395.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi HYSTMNA.

Enzyme and pathway databases

BioCyci SBIN749414:GHKA-3290-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7C8K9_STRBB
AccessioniPrimary (citable) accession number: D7C8K9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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