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D7C8K9

- D7C8K9_STRBB

UniProt

D7C8K9 - D7C8K9_STRBB

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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBIN749414:GHKA-3290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotationSAAS annotation (EC:2.7.1.21UniRule annotationSAAS annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SBI_03277Imported
OrganismiStreptomyces bingchenggensis (strain BCW-1)Imported
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000377: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiHYSTMNA.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

D7C8K9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPELVFFSGT MDCGKSTLAL QIEHNRSARG LQGMIYTRDD RAGRGKLSSR
60 70 80 90 100
LGLVTEAVEA GDDLDFYAHV VGILTAGGRA DYVIVDEAQF LAPSQIDQLA
110 120 130 140 150
RVVDDLGLDV FAFGITTDFR SKLFPGSQRL VELADRIEVL QVEALCWCGA
160 170 180 190 200
RATHNARTVG GEMVVEGAQV VVGDVNQPGA EVGYEVLCRR HHRRRMTAAA
210 220 230
ARAATLSPDV LPVDPAAAPA PVPHQAQTPR TAP
Length:233
Mass (Da):25,003
Last modified:August 10, 2010 - v1
Checksum:i7332DB8445E1DC16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI06398.1.
RefSeqiWP_014175875.1. NC_016582.1.
YP_004961529.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI06398; ADI06398; SBI_03277.
GeneIDi11612431.
KEGGisbh:SBI_03277.
PATRICi43264378. VBIStrBin158249_3395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI06398.1 .
RefSeqi WP_014175875.1. NC_016582.1.
YP_004961529.1. NC_016582.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI06398 ; ADI06398 ; SBI_03277 .
GeneIDi 11612431.
KEGGi sbh:SBI_03277.
PATRICi 43264378. VBIStrBin158249_3395.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi HYSTMNA.

Enzyme and pathway databases

BioCyci SBIN749414:GHKA-3290-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis."
    Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L., Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X., Xiang W.S.
    J. Bacteriol. 192:4526-4527(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCW-1Imported.

Entry informationi

Entry nameiD7C8K9_STRBB
AccessioniPrimary (citable) accession number: D7C8K9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3