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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Streptomyces bingchenggensis (strain BCW-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei451D-inositol 3-phosphateUniRule annotation1
Binding sitei59UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei1141D-inositol 3-phosphateUniRule annotation1
Binding sitei1471D-inositol 3-phosphateUniRule annotation1
Binding sitei1711D-inositol 3-phosphateUniRule annotation1
Binding sitei1911D-inositol 3-phosphateUniRule annotation1
Binding sitei266UDP-GlcNAcUniRule annotation1
Binding sitei271UDP-GlcNAcUniRule annotation1
Metal bindingi341Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi342Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi344Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei354UDP-GlcNAcUniRule annotation1
Binding sitei362UDP-GlcNAcUniRule annotation1
Metal bindingi368MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:SBI_05009
OrganismiStreptomyces bingchenggensis (strain BCW-1)
Taxonomic identifieri749414 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001611 – 455D-inositol 3-phosphate glycosyltransferaseAdd BLAST455

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi749414.SBI_05009.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 52UDP-GlcNAc bindingUniRule annotation2
Regioni56 – 611D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

D7C367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQHVSRLGG LRGRSHGHGA FGGPYHQRLR RVGRRPRRIA MLSVHTSPLH
60 70 80 90 100
QPGTGDAGGM NVYIVELAKR LAAIDIEVEI FTRATTGTLP PTVELAPGVL
110 120 130 140 150
VRHVDAGPYE GLAKEDLPAQ LCAFTHGVMG AWAGHRPGYY DLVHSHYWLS
160 170 180 190 200
GHVGWLAAER WRVPLVHAMH TMAKVKNAAL AEGDTPEPAA RVIGEEQIVG
210 220 230 240 250
AADRLIANTE EEADELVRHY GADPELVAVV HPGVNLERFR PADGRAAARA
260 270 280 290 300
RLGLPPDALI PLFAGRIQPL KAPDILLHAV AHLLDEDPRL RERIVVPVVG
310 320 330 340 350
GPSGSGLAKP ERLHKLAARL GVSDVIRFRP PCTQDELADW YRAASVLVMP
360 370 380 390 400
SYNESFGLVA IEAQACGTPV IAAEVGGLPV AVRDGHSGIL VPGHNPADYA
410 420 430 440 450
RELHRLSADP GLLKRLGSGA AHHAERFGWD KAAAATADVY AEAMRGYRRL

RSVHG
Length:455
Mass (Da):48,982
Last modified:August 10, 2010 - v1
Checksum:i35F7C0A02E619BD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI08129.1.
RefSeqiWP_014177596.1. NC_016582.1.

Genome annotation databases

EnsemblBacteriaiADI08129; ADI08129; SBI_05009.
KEGGisbh:SBI_05009.
PATRICi43267974. VBIStrBin158249_5180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002047 Genomic DNA. Translation: ADI08129.1.
RefSeqiWP_014177596.1. NC_016582.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi749414.SBI_05009.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI08129; ADI08129; SBI_05009.
KEGGisbh:SBI_05009.
PATRICi43267974. VBIStrBin158249_5180.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_STRBB
AccessioniPrimary (citable) accession number: D7C367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.