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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotationSAAS annotation

Pathway: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathway: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathway: glycolysis

This protein is involved in step 1 and 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA), Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Pathway: glycolysis

This protein is involved in step 1 and 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA), Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101SubstrateUniRule annotation
Binding sitei12 – 121SubstrateUniRule annotation
Active sitei102 – 1021ElectrophileUniRule annotation
Active sitei174 – 1741Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation, Pentose shuntUniRule annotation

Enzyme and pathway databases

BioCyciAHAE644284:GI54-914-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Arch_0882Imported
OrganismiArcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018)Imported
Taxonomic identifieri644284 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinomycetalesActinomycetaceaeArcanobacterium
ProteomesiUP000000376 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi644284.Arch_0882.

Structurei

3D structure databases

ProteinModelPortaliD7BNV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226413.
KOiK01803.
OMAiEANRICG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7BNV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTPIMAGN WKMNLDHLEA TALVQKLGWT LNDLKHDFSA VECVVVPPFT
60 70 80 90 100
DIRSVQTLVD SEDFKITYGA QDVSINDEGA FTGEISTGML TKLGVTYVVV
110 120 130 140 150
GHSERREYHG ETNELIGKKA KKVLDAGMTP IVCCGEALEI RKEGTHVEYV
160 170 180 190 200
LGQIAAMFAD LSAEEVAKLV IAYEPIWAIG TGEVATPADA QEVCGAIRGK
210 220 230 240 250
IAEMFDAPTA EAVRIQYGGS VKSSNVVEIM AQPDVDGALV GGASLKAEEF

AKIVTFQQA
Length:259
Mass (Da):27,809
Last modified:August 10, 2010 - v1
Checksum:i92B546D50378A8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002045 Genomic DNA. Translation: ADH92608.1.
RefSeqiWP_013170104.1. NC_014218.1.
YP_003697227.1. NC_014218.1.

Genome annotation databases

EnsemblBacteriaiADH92608; ADH92608; Arch_0882.
KEGGiahe:Arch_0882.
PATRICi38110735. VBIArcHae78728_0863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002045 Genomic DNA. Translation: ADH92608.1.
RefSeqiWP_013170104.1. NC_014218.1.
YP_003697227.1. NC_014218.1.

3D structure databases

ProteinModelPortaliD7BNV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi644284.Arch_0882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADH92608; ADH92608; Arch_0882.
KEGGiahe:Arch_0882.
PATRICi38110735. VBIArcHae78728_0863.

Phylogenomic databases

HOGENOMiHOG000226413.
KOiK01803.
OMAiEANRICG.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.
BioCyciAHAE644284:GI54-914-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018Imported.

Entry informationi

Entry nameiD7BNV9_ARCHD
AccessioniPrimary (citable) accession number: D7BNV9
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.