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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotationSAAS annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102ElectrophileUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1
Binding sitei220SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotationSAAS annotation, GlycolysisUniRule annotationSAAS annotation, Pentose shuntUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Arch_0882Imported
OrganismiArcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / NBRC 15585 / NCTC 8452 / 11018)Imported
Taxonomic identifieri644284 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinomycetalesActinomycetaceaeArcanobacterium
Proteomesi
  • UP000000376 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi644284.Arch_0882.

Structurei

3D structure databases

ProteinModelPortaliD7BNV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 12Substrate bindingUniRule annotation3
Regioni241 – 242Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CP7. Bacteria.
COG0149. LUCA.
HOGENOMiHOG000226413.
KOiK01803.
OMAiLCVGEGL.
OrthoDBiPOG091H02GL.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D7BNV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTPIMAGN WKMNLDHLEA TALVQKLGWT LNDLKHDFSA VECVVVPPFT
60 70 80 90 100
DIRSVQTLVD SEDFKITYGA QDVSINDEGA FTGEISTGML TKLGVTYVVV
110 120 130 140 150
GHSERREYHG ETNELIGKKA KKVLDAGMTP IVCCGEALEI RKEGTHVEYV
160 170 180 190 200
LGQIAAMFAD LSAEEVAKLV IAYEPIWAIG TGEVATPADA QEVCGAIRGK
210 220 230 240 250
IAEMFDAPTA EAVRIQYGGS VKSSNVVEIM AQPDVDGALV GGASLKAEEF

AKIVTFQQA
Length:259
Mass (Da):27,809
Last modified:August 10, 2010 - v1
Checksum:i92B546D50378A8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002045 Genomic DNA. Translation: ADH92608.1.
RefSeqiWP_013170104.1. NC_014218.1.

Genome annotation databases

EnsemblBacteriaiADH92608; ADH92608; Arch_0882.
KEGGiahe:Arch_0882.

Similar proteinsi

Entry informationi

Entry nameiD7BNV9_ARCHD
AccessioniPrimary (citable) accession number: D7BNV9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 27, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported