ID   D7BK24_ARCHD            Unreviewed;       857 AA.
AC   D7BK24;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Arch_1299 {ECO:0000313|EMBL:ADH93004.1};
OS   Arcanobacterium haemolyticum (strain ATCC 9345 / DSM 20595 / CCUG 17215 /
OS   LMG 16163 / NBRC 15585 / NCTC 8452 / 11018).
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Arcanobacterium.
OX   NCBI_TaxID=644284 {ECO:0000313|EMBL:ADH93004.1, ECO:0000313|Proteomes:UP000000376};
RN   [1] {ECO:0000313|EMBL:ADH93004.1, ECO:0000313|Proteomes:UP000000376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9345 / DSM 20595 / CCUG 17215 / LMG 16163 / NBRC 15585 /
RC   NCTC 8452 / 11018 {ECO:0000313|Proteomes:UP000000376};
RX   PubMed=21304742; DOI=10.4056/sigs.1123072;
RA   Yasawong M., Teshima H., Lapidus A., Nolan M., Lucas S.,
RA   Glavina Del Rio T., Tice H., Cheng J., Bruce D., Detter C., Tapia R.,
RA   Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Chang Y., Jeffries C., Rohde M., Sikorski J., Pukall R., Goker M.,
RA   Woyke T., Bristow J., Eisen J., Markowitz V., Hugenholtz P., Kyrpides N.,
RA   Klenk H.;
RT   "Complete genome sequence of Arcanobacterium haemolyticum type strain
RT   (11018).";
RL   Stand. Genomic Sci. 3:126-135(2010).
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DR   EMBL; CP002045; ADH93004.1; -; Genomic_DNA.
DR   RefSeq; WP_013170496.1; NC_014218.1.
DR   AlphaFoldDB; D7BK24; -.
DR   STRING; 644284.Arch_1299; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; ahe:Arch_1299; -.
DR   eggNOG; COG3064; Bacteria.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_333359_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000376; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000376};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..857
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005672028"
FT   TRANSMEM        830..851
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          212..530
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          600..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   857 AA;  92191 MW;  79EB76659F0C0CEB CRC64;
     MRKFTSRLVA GIATMGLLIA PALPASASSE VINKRTLVNH AKTVGDAGTA YLAVDNGPED
     DVVRVGETIS FESRFQSGLS EIVYVKATSE ALGDTQADKC SWRGVPYNSG AQLRQIPAKD
     GYWCVQKPSY KVKEADLEHP TKTFDITYNV YKDANASGKP FSTLTVKKTV KIQKAIENPG
     EKDGPKDVLL AKANDFDFPV HRIPALAKAP NGNLLAAWDG RPAVYSNNDS PNPNTILLRI
     SKDNGETWEP VQKIASGQLR DKASGKKQIG YSDPSFVVDN VSGKVFAFFV KSYDQGIAGS
     RSGVDPEDPN VIHAVYVVSE NNGESWSAPK DVTGILAEGY KQHARFATSG AGIQLKYGDH
     PGRLIQQYLV VNNGQDGNWG SGEHQAVSLY SDDNGKTWHS GKPVGTTMDE NKVVELSDGK
     VLLSSRQFHH RGGRHYAISS DGGINYQMDY TNDNRLADPQ NNASIIRAFP EAKKGSALAK
     VLLSSHANSR KHYDRVNGTI SYSLDDGATW TNGSVFKPGK MQYSVMTALG NDAYGILYEG
     NDSTIVYKKV DLNWISPELA KYAEDHKADL GNADSEAAEK IKKLEDEIAD LKAKLEAANQ
     AKDEAEKAAK KAEEEKRDAD REKVKAETAK REVEAKLKKA EGDKADLEKR VAELEGDIAK
     AEEAKKAADK AVEEANAAKK KAEEEAAELK AKNAELEKKL KEAGKAEIPL VPLTPAEPTP
     APEPQPAPAI SMVSDKVAVG SQVVFTGTGF TPDAKVKVAV HSTAVELGEY VADKDGKITV
     TWTVPAGFEL GAHKVIFTAG DKTVEKSFTV VAPEKPVPTK PAAPGLAKTG VTLGLVAGLA
     TLSIMAGVVA VRRRHEV
//