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D7BFL4

- D7BFL4_MEISD

UniProt

D7BFL4 - D7BFL4_MEISD

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Mesil_1684

Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-1715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Mesil_1684Imported
OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
Taxonomic identifieri526227 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000001916: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7BFL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7BFL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYKHIQVPE GEKITIQNGQ LQVPDRPILG FIEGDGTGPD IWRASQPVLD
60 70 80 90 100
AAVEKAYGGK KKIAWTEIYA GEKANAVYGE AVWLPEETLD FIREYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSINVALRQ ELDLYACVRP VQWFEGVPSP VRHPELVNMV
160 170 180 190 200
IFRENTEDIY AGIEWAAGTS EAKKLLEFLK AEFPKAYGKI RFPETAGVGI
210 220 230 240 250
KPISQEGTYR LVEAAINYAI ANNLPSVTLV HKGNIMKFTE GAFRDWGYRL
260 270 280 290 300
AKEKYGAQDL DGSPWQILKN PRTGGDIVIK DMIADNFLQQ ILLRPAEYSV
310 320 330 340 350
VATPNLNGDY LSDALAAQVG GIGIAPGANI NYYTGHAVFE ATHGTAPKYA
360 370 380 390 400
GKDQVNPSSV ILSGEMMLRY LGWTEAADLI LSAMTKTIAQ GRVTYDFHRL
410 420
MVAEGRPATL LKCSEFGQAL VENMG
Length:425
Mass (Da):46,622
Last modified:August 10, 2010 - v1
Checksum:iFEA8093EE8BB1A47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH63567.1.
RefSeqiWP_013158129.1. NC_014212.1.
YP_003685075.1. NC_014212.1.

Genome annotation databases

EnsemblBacteriaiADH63567; ADH63567; Mesil_1684.
GeneIDi9251190.
KEGGimsv:Mesil_1684.
PATRICi38192167. VBIMeiSil18825_1727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH63567.1 .
RefSeqi WP_013158129.1. NC_014212.1.
YP_003685075.1. NC_014212.1.

3D structure databases

ProteinModelPortali D7BFL4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH63567 ; ADH63567 ; Mesil_1684 .
GeneIDi 9251190.
KEGGi msv:Mesil_1684.
PATRICi 38192167. VBIMeiSil18825_1727.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.

Enzyme and pathway databases

BioCyci MSIL526227:GJ9Q-1715-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700542 / DSM 9946 / VI-R2Imported.

Entry informationi

Entry nameiD7BFL4_MEISD
AccessioniPrimary (citable) accession number: D7BFL4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3