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D7BFL4

- D7BFL4_MEISD

UniProt

D7BFL4 - D7BFL4_MEISD

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Mesil_1684
Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-1715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Mesil_1684Imported
OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
Taxonomic identifieri526227 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000001916: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7BFL4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7BFL4-1 [UniParc]FASTAAdd to Basket

« Hide

MAYKHIQVPE GEKITIQNGQ LQVPDRPILG FIEGDGTGPD IWRASQPVLD    50
AAVEKAYGGK KKIAWTEIYA GEKANAVYGE AVWLPEETLD FIREYRVAIK 100
GPLTTPVGGG IRSINVALRQ ELDLYACVRP VQWFEGVPSP VRHPELVNMV 150
IFRENTEDIY AGIEWAAGTS EAKKLLEFLK AEFPKAYGKI RFPETAGVGI 200
KPISQEGTYR LVEAAINYAI ANNLPSVTLV HKGNIMKFTE GAFRDWGYRL 250
AKEKYGAQDL DGSPWQILKN PRTGGDIVIK DMIADNFLQQ ILLRPAEYSV 300
VATPNLNGDY LSDALAAQVG GIGIAPGANI NYYTGHAVFE ATHGTAPKYA 350
GKDQVNPSSV ILSGEMMLRY LGWTEAADLI LSAMTKTIAQ GRVTYDFHRL 400
MVAEGRPATL LKCSEFGQAL VENMG 425
Length:425
Mass (Da):46,622
Last modified:August 10, 2010 - v1
Checksum:iFEA8093EE8BB1A47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002042 Genomic DNA. Translation: ADH63567.1.
RefSeqiYP_003685075.1. NC_014212.1.

Genome annotation databases

EnsemblBacteriaiADH63567; ADH63567; Mesil_1684.
GeneIDi9251190.
KEGGimsv:Mesil_1684.
PATRICi38192167. VBIMeiSil18825_1727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002042 Genomic DNA. Translation: ADH63567.1 .
RefSeqi YP_003685075.1. NC_014212.1.

3D structure databases

ProteinModelPortali D7BFL4.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH63567 ; ADH63567 ; Mesil_1684 .
GeneIDi 9251190.
KEGGi msv:Mesil_1684.
PATRICi 38192167. VBIMeiSil18825_1727.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.

Enzyme and pathway databases

BioCyci MSIL526227:GJ9Q-1715-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700542 / DSM 9946 / VI-R2.

Entry informationi

Entry nameiD7BFL4_MEISD
AccessioniPrimary (citable) accession number: D7BFL4
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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