Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

D7BFL4

- D7BFL4_MEISD

UniProt

D7BFL4 - D7BFL4_MEISD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Mesil_1684

Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciMSIL526227:GJ9Q-1715-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Mesil_1684Imported
    OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
    Taxonomic identifieri526227 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
    ProteomesiUP000001916: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliD7BFL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7BFL4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYKHIQVPE GEKITIQNGQ LQVPDRPILG FIEGDGTGPD IWRASQPVLD    50
    AAVEKAYGGK KKIAWTEIYA GEKANAVYGE AVWLPEETLD FIREYRVAIK 100
    GPLTTPVGGG IRSINVALRQ ELDLYACVRP VQWFEGVPSP VRHPELVNMV 150
    IFRENTEDIY AGIEWAAGTS EAKKLLEFLK AEFPKAYGKI RFPETAGVGI 200
    KPISQEGTYR LVEAAINYAI ANNLPSVTLV HKGNIMKFTE GAFRDWGYRL 250
    AKEKYGAQDL DGSPWQILKN PRTGGDIVIK DMIADNFLQQ ILLRPAEYSV 300
    VATPNLNGDY LSDALAAQVG GIGIAPGANI NYYTGHAVFE ATHGTAPKYA 350
    GKDQVNPSSV ILSGEMMLRY LGWTEAADLI LSAMTKTIAQ GRVTYDFHRL 400
    MVAEGRPATL LKCSEFGQAL VENMG 425
    Length:425
    Mass (Da):46,622
    Last modified:August 10, 2010 - v1
    Checksum:iFEA8093EE8BB1A47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002042 Genomic DNA. Translation: ADH63567.1.
    RefSeqiYP_003685075.1. NC_014212.1.

    Genome annotation databases

    EnsemblBacteriaiADH63567; ADH63567; Mesil_1684.
    GeneIDi9251190.
    KEGGimsv:Mesil_1684.
    PATRICi38192167. VBIMeiSil18825_1727.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002042 Genomic DNA. Translation: ADH63567.1 .
    RefSeqi YP_003685075.1. NC_014212.1.

    3D structure databases

    ProteinModelPortali D7BFL4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADH63567 ; ADH63567 ; Mesil_1684 .
    GeneIDi 9251190.
    KEGGi msv:Mesil_1684.
    PATRICi 38192167. VBIMeiSil18825_1727.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci MSIL526227:GJ9Q-1715-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700542 / DSM 9946 / VI-R2Imported.

    Entry informationi

    Entry nameiD7BFL4_MEISD
    AccessioniPrimary (citable) accession number: D7BFL4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3