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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

Mesil_1295

Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: InterPro
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-1316-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Mesil_1295Imported
OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
Taxonomic identifieri526227 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000001916 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7BEE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRGIKVWP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7BEE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTPITVAY GDGIGPEIME AVLKILDAAQ ARIAPEVIEI GESVYLRGHT
60 70 80 90 100
SGIEESAWES LRRTKVFLKA PITTPRGGGY KSLNVTVRKT LGLYANVRPV
110 120 130 140 150
QSYEPFVTTK HKSIDLVIVR ENEEDLYAGI EHQQTDEVVQ CLKLISRPGT
160 170 180 190 200
ERIVRYAYEF ARRNGCRKIT CITKDNIMKL TDGLFHRVFD EVGQEYPELQ
210 220 230 240 250
KEHMIVDIGA ARLAEMPERF DVILAPNLYG DILSDIAAEV AGSVGLAGSA
260 270 280 290 300
NVGDEVAMFE AVHGSAPDIA GKGIANPSGL LQGAILMLVH IGQSEVAARI
310 320 330 340 350
KNAWLKTLED GIHTPDIYDE RVSEKKVGTQ EFAQAVIERL GQEPERLRPA
360 370 380 390 400
RFGKPSPEPM VPKLERKTPA QKELVGVDVF FNWRGQKPEE LAAMLEPLAG
410 420 430 440 450
QNLELVMITN RGVKVWPGGF PETFRTDHWR GRFMGQGREV RHSDVVALLG
460 470 480
RLAEAGLDFI KTEHLYTFDG KPGYSLGQGQ
Length:480
Mass (Da):53,106
Last modified:August 10, 2010 - v1
Checksum:i8459FC418498A654
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH63189.1.
RefSeqiYP_003684697.1. NC_014212.1.

Genome annotation databases

EnsemblBacteriaiADH63189; ADH63189; Mesil_1295.
KEGGimsv:Mesil_1295.
PATRICi38191346. VBIMeiSil18825_1327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH63189.1.
RefSeqiYP_003684697.1. NC_014212.1.

3D structure databases

ProteinModelPortaliD7BEE6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADH63189; ADH63189; Mesil_1295.
KEGGimsv:Mesil_1295.
PATRICi38191346. VBIMeiSil18825_1327.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRGIKVWP.

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-1316-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR014273. Isocitrate_DH_aproteobac-typ.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02924. ICDH_alpha. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700542 / DSM 9946 / VI-R2Imported.

Entry informationi

Entry nameiD7BEE6_MEISD
AccessioniPrimary (citable) accession number: D7BEE6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 1, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.