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Protein

Xylose isomerase

Gene

xylA

Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541UniRule annotation
Active sitei57 – 571UniRule annotation
Metal bindingi181 – 1811Magnesium 1UniRule annotation
Metal bindingi217 – 2171Magnesium 1UniRule annotation
Metal bindingi217 – 2171Magnesium 2UniRule annotation
Metal bindingi220 – 2201Magnesium 2UniRule annotation
Metal bindingi245 – 2451Magnesium 1UniRule annotation
Metal bindingi255 – 2551Magnesium 2UniRule annotation
Metal bindingi257 – 2571Magnesium 2UniRule annotation
Metal bindingi287 – 2871Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Mesil_0695Imported
OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
Taxonomic identifieri526227 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
ProteomesiUP000001916 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7BB51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7BB51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYEPKPEHK FTFGLWTVGN VGRDPFGLPT RPPLEPDYIV YKLAEIGAYG
60 70 80 90 100
VNLHDNDLIP VEATEAERER ILKRFKKALQ DTGLVVPMAT TNLFGDPAFK
110 120 130 140 150
DGAFTSPDAR VRAYALQKTM RAMDLGAELG AKTYVFWGGR EGAEVDAGGN
160 170 180 190 200
VLDALAHYRE ALNFLAEYSE DQGYGYRFAL EPKPNEPRGD IYLPVVGAAL
210 220 230 240 250
GFIATLDKPH LFGLNPEVAH ETMAGLNFVH AVAQAIDAGK LFHIDLNDQK
260 270 280 290 300
MGRFDQDLRF GAENLKTAFF LVKLLEDSGY DGPRHFDAHA LRTEDEAGVW
310 320 330 340 350
EFAKGCMRTY LILKEKAERF GRDREIQDLI GAYKVQDEAL ARLTAKYSRE
360 370 380
NARALKGLEF DREALGRRGP GLERLDQLTV ELLLGVR
Length:387
Mass (Da):43,213
Last modified:August 9, 2010 - v1
Checksum:iAD35B8C5DC7A81AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH62611.1.
RefSeqiYP_003684119.1. NC_014212.1.

Genome annotation databases

EnsemblBacteriaiADH62611; ADH62611; Mesil_0695.
KEGGimsv:Mesil_0695.
PATRICi38190106. VBIMeiSil18825_0712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA. Translation: ADH62611.1.
RefSeqiYP_003684119.1. NC_014212.1.

3D structure databases

ProteinModelPortaliD7BB51.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADH62611; ADH62611; Mesil_0695.
KEGGimsv:Mesil_0695.
PATRICi38190106. VBIMeiSil18825_0712.

Phylogenomic databases

HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.

Enzyme and pathway databases

BioCyciMSIL526227:GJ9Q-709-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700542 / DSM 9946 / VI-R2Imported.

Entry informationi

Entry nameiD7BB51_MEISD
AccessioniPrimary (citable) accession number: D7BB51
Entry historyi
Integrated into UniProtKB/TrEMBL: August 9, 2010
Last sequence update: August 9, 2010
Last modified: March 31, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.