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Protein

Xylose isomerase

Gene

xylA

Organism
Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54UniRule annotation1
Active sitei57UniRule annotation1
Metal bindingi181Magnesium 1UniRule annotation1
Metal bindingi217Magnesium 1UniRule annotation1
Metal bindingi217Magnesium 2UniRule annotation1
Metal bindingi220Magnesium 2UniRule annotation1
Metal bindingi245Magnesium 1UniRule annotation1
Metal bindingi255Magnesium 2UniRule annotation1
Metal bindingi257Magnesium 2UniRule annotation1
Metal bindingi287Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processCarbohydrate metabolism, Xylose metabolismUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSIL526227:G1GKK-708-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.5UniRule annotationSAAS annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Mesil_0695Imported
OrganismiMeiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus silvanus)Imported
Taxonomic identifieri526227 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeMeiothermus
Proteomesi
  • UP000001916 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi526227.Mesil_0695

Structurei

3D structure databases

ProteinModelPortaliD7BB51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 248AP_endonuc_2InterPro annotationAdd BLAST207

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 81Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C93 Bacteria
COG2115 LUCA
HOGENOMiHOG000022596
KOiK01805
OMAiNQLAIEH
OrthoDBiPOG091H07LC

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013453 XylA_actinobac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02631 xylA_Arthro, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

D7BB51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYEPKPEHK FTFGLWTVGN VGRDPFGLPT RPPLEPDYIV YKLAEIGAYG
60 70 80 90 100
VNLHDNDLIP VEATEAERER ILKRFKKALQ DTGLVVPMAT TNLFGDPAFK
110 120 130 140 150
DGAFTSPDAR VRAYALQKTM RAMDLGAELG AKTYVFWGGR EGAEVDAGGN
160 170 180 190 200
VLDALAHYRE ALNFLAEYSE DQGYGYRFAL EPKPNEPRGD IYLPVVGAAL
210 220 230 240 250
GFIATLDKPH LFGLNPEVAH ETMAGLNFVH AVAQAIDAGK LFHIDLNDQK
260 270 280 290 300
MGRFDQDLRF GAENLKTAFF LVKLLEDSGY DGPRHFDAHA LRTEDEAGVW
310 320 330 340 350
EFAKGCMRTY LILKEKAERF GRDREIQDLI GAYKVQDEAL ARLTAKYSRE
360 370 380
NARALKGLEF DREALGRRGP GLERLDQLTV ELLLGVR
Length:387
Mass (Da):43,213
Last modified:August 10, 2010 - v1
Checksum:iAD35B8C5DC7A81AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002042 Genomic DNA Translation: ADH62611.1
RefSeqiWP_013157200.1, NC_014212.1

Genome annotation databases

EnsemblBacteriaiADH62611; ADH62611; Mesil_0695
KEGGimsv:Mesil_0695

Similar proteinsi

Entry informationi

Entry nameiD7BB51_MEISD
AccessioniPrimary (citable) accession number: D7BB51
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health