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Protein

Alanine racemase

Gene

Ndas_4045

Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509) (Actinomadura dassonvillei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Ndas_4045), Alanine racemase (Ndas_5375)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Active sitei264Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei312Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNDAS446468:GHUM-4037-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Ndas_4045Imported
OrganismiNocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509) (Actinomadura dassonvillei)Imported
Taxonomic identifieri446468 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesNocardiopsaceaeNocardiopsis
Proteomesi
  • UP000002219 Componenti: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi446468.Ndas_4045.

Structurei

3D structure databases

ProteinModelPortaliD7B7P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 372Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

D7B7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHFAHARVD LDAISHNARV LRGFAGGTPL MGVVKADGYG HGMLPAARAL
60 70 80 90 100
IAGGATWLGT AFIGEALELR RAGLTPPVLA WIIPPGEPVA EAVEADIDLG
110 120 130 140 150
VSDRAVLDTV IAEARRIGRT ARVQLKADTG LNRGGVGPAD WGALAEAAAR
160 170 180 190 200
AEDEGHLRVT GVWSHFACAD EPGHPSVARQ LSRFHEALET ADKVGLTPEV
210 220 230 240 250
RHIANSAALL TLPEARFDLV RGGIASYGLS PIPGLTGTGL RPAMTLRSRL
260 270 280 290 300
ALTKRVPEGS GVSYGHRYVT DRETTLALVP LGYADGVPRA ATNRGPVLLG
310 320 330 340 350
GRRRAVAGTV CMDQFVVDVG DDAVEAGEYA VLFGNPEDHP DTPTAEDWAE
360 370
ILDTIPYEIV TRVGPRVPRE YVGGGA
Length:376
Mass (Da):39,531
Last modified:August 10, 2010 - v1
Checksum:i41F76288EB34F862
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002040 Genomic DNA. Translation: ADH69442.1.
RefSeqiWP_013155049.1. NC_014210.1.

Genome annotation databases

EnsemblBacteriaiADH69442; ADH69442; Ndas_4045.
KEGGinda:Ndas_4045.

Similar proteinsi

Entry informationi

Entry nameiD7B7P7_NOCDD
AccessioniPrimary (citable) accession number: D7B7P7
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported