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Protein

Thymidine kinase

Gene

Ndas_0149

Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) (Actinomadura dassonvillei)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNDAS446468:GHUM-154-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Ordered Locus Names:Ndas_0149Imported
OrganismiNocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) (Actinomadura dassonvillei)Imported
Taxonomic identifieri446468 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptosporangineaeNocardiopsaceaeNocardiopsis
ProteomesiUP000002219: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliD7B745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7B745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELKYFTGS MNSGKSTMAL QEHHSRGGEG VLYTKQDRAG AGIISSRLGL
60 70 80 90 100
ESPAVEVGDD LDLYDDIADR KAPYVICDEA QFLSYKQVGQ LAGVVDGMRI
110 120 130 140 150
DVYCYGILTD FQGQLFPGSK RLVELADKIE VLPVSARCWC GGRATHNARV
160 170 180
VDGVMIYEGE QVHIGGNESY ATLCRHHFMA GVA
Length:183
Mass (Da):19,925
Last modified:August 10, 2010 - v1
Checksum:i732DB459AB49BE99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002040 Genomic DNA. Translation: ADH65599.1.
RefSeqiYP_003678105.1. NC_014210.1.

Genome annotation databases

EnsemblBacteriaiADH65599; ADH65599; Ndas_0149.
GeneIDi9243980.
KEGGinda:Ndas_0149.
PATRICi38210028. VBINocDas52663_0156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002040 Genomic DNA. Translation: ADH65599.1.
RefSeqiYP_003678105.1. NC_014210.1.

3D structure databases

ProteinModelPortaliD7B745.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADH65599; ADH65599; Ndas_0149.
GeneIDi9243980.
KEGGinda:Ndas_0149.
PATRICi38210028. VBINocDas52663_0156.

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Enzyme and pathway databases

BioCyciNDAS446468:GHUM-154-MONOMER.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488Imported.

Entry informationi

Entry nameiD7B745_NOCDD
AccessioniPrimary (citable) accession number: D7B745
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: January 7, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.