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D7AU45

- D7AU45_THEM3

UniProt

D7AU45 - D7AU45_THEM3

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Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene
dapB, Tmath_0814
Organism
Thermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei141 – 1411Proton donor/acceptor By similarityUniRule annotation
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Active sitei145 – 1451Proton donor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NAD(P) By similarityUniRule annotation
Nucleotide bindingi84 – 863NAD(P) By similarityUniRule annotation
Nucleotide bindingi108 – 1114NAD(P) By similarityUniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotations, Lysine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations, NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTMAT583358:GHOX-843-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotation
Ordered Locus Names:Tmath_0814Imported
OrganismiThermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
Taxonomic identifieri583358 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002064: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD7AU45.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 1522Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227155.
KOiK00215.
OMAiDITGEHE.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7AU45-1 [UniParc]FASTAAdd to Basket

« Hide

MIRIIIHGCN GKMGKVVAKL AAENPDFKIV AGVDKNLSPL EFPVYSDLKD    50
VKEEADVVID FSYHEAVPNL VKAALQKKLP VVIATTGLSE EELNVIKDAS 100
KEIPIFKSAN MSLGVNILIN LVKEAAKILQ QDFDIEIIEK HHNMKKDAPS 150
GTALMIADSI NQVLNDKKEY VYGRHTKTEQ RKTNELGIHA VRGGTIVGEH 200
QVIFAGHDEV ITISHSAQSR EIFGYGALHA AKFIIGQKPG LYSMEDLVKK 250
G 251
Length:251
Mass (Da):27,590
Last modified:August 10, 2010 - v1
Checksum:i98864B69DD71890F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60552.1.
RefSeqiYP_003676563.1. NC_014209.1.

Genome annotation databases

EnsemblBacteriaiADH60552; ADH60552; Tmath_0814.
GeneIDi9242305.
KEGGitmt:Tmath_0814.
PATRICi38279747. VBITheMat18_0844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60552.1 .
RefSeqi YP_003676563.1. NC_014209.1.

3D structure databases

ProteinModelPortali D7AU45.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH60552 ; ADH60552 ; Tmath_0814 .
GeneIDi 9242305.
KEGGi tmt:Tmath_0814.
PATRICi 38279747. VBITheMat18_0844.

Phylogenomic databases

HOGENOMi HOG000227155.
KOi K00215.
OMAi DITGEHE.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci TMAT583358:GHOX-843-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11426 / CIP 108742 / A3.

Entry informationi

Entry nameiD7AU45_THEM3
AccessioniPrimary (citable) accession number: D7AU45
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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