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D7AU45

- D7AU45_THEM3

UniProt

D7AU45 - D7AU45_THEM3

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Thermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411Proton donor/acceptorUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Active sitei145 – 1451Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NAD(P)UniRule annotation
    Nucleotide bindingi84 – 863NAD(P)UniRule annotation
    Nucleotide bindingi108 – 1114NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTMAT583358:GHOX-843-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotation
    Ordered Locus Names:Tmath_0814Imported
    OrganismiThermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
    Taxonomic identifieri583358 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002064: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD7AU45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni151 – 1522Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000227155.
    KOiK00215.
    OMAiDITGEHE.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7AU45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRIIIHGCN GKMGKVVAKL AAENPDFKIV AGVDKNLSPL EFPVYSDLKD    50
    VKEEADVVID FSYHEAVPNL VKAALQKKLP VVIATTGLSE EELNVIKDAS 100
    KEIPIFKSAN MSLGVNILIN LVKEAAKILQ QDFDIEIIEK HHNMKKDAPS 150
    GTALMIADSI NQVLNDKKEY VYGRHTKTEQ RKTNELGIHA VRGGTIVGEH 200
    QVIFAGHDEV ITISHSAQSR EIFGYGALHA AKFIIGQKPG LYSMEDLVKK 250
    G 251
    Length:251
    Mass (Da):27,590
    Last modified:August 10, 2010 - v1
    Checksum:i98864B69DD71890F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002032 Genomic DNA. Translation: ADH60552.1.
    RefSeqiYP_003676563.1. NC_014209.1.

    Genome annotation databases

    EnsemblBacteriaiADH60552; ADH60552; Tmath_0814.
    GeneIDi9242305.
    KEGGitmt:Tmath_0814.
    PATRICi38279747. VBITheMat18_0844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002032 Genomic DNA. Translation: ADH60552.1 .
    RefSeqi YP_003676563.1. NC_014209.1.

    3D structure databases

    ProteinModelPortali D7AU45.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADH60552 ; ADH60552 ; Tmath_0814 .
    GeneIDi 9242305.
    KEGGi tmt:Tmath_0814.
    PATRICi 38279747. VBITheMat18_0844.

    Phylogenomic databases

    HOGENOMi HOG000227155.
    KOi K00215.
    OMAi DITGEHE.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci TMAT583358:GHOX-843-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11426 / CIP 108742 / A3Imported.

    Entry informationi

    Entry nameiD7AU45_THEM3
    AccessioniPrimary (citable) accession number: D7AU45
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3