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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Thermoanaerobacter mathranii subsp. mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Tmath_1619)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei87Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMAT583358:G1GLO-2113-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:Tmath_2073Imported
OrganismiThermoanaerobacter mathranii subsp. mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
Taxonomic identifieri583358 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
Proteomesi
  • UP000002064 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD7ASV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni114 – 115Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.12401 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

D7ASV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKVVLLRHG ESLWNMENRF TGWTDIDLSP KGVEEARESG KTLKAEGYIF
60 70 80 90 100
DCAFTSVLKR AIRTLWIVLD ELDLMWIPVY KSWRLNERHY GALQGLNKAE
110 120 130 140 150
TAKKYGEEQV KIWRRSADVR PPALEKDDPR YPGFDPRYAD LSEEEIPLTE
160 170 180 190 200
NLIDTINRVT SYWESTIAPT IKSGKKVLIV AHGNSLRGLV KYLDNLSNEE
210 220 230 240 250
IMELNIPTGI PLVYELDGDL KPIKHYYLAD EEKVKEKKEL VAKQGKVQGN

S
Length:251
Mass (Da):28,885
Last modified:August 10, 2010 - v1
Checksum:i49D483F050664340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002032 Genomic DNA Translation: ADH61747.1
RefSeqiWP_013150903.1, NC_014209.1

Genome annotation databases

EnsemblBacteriaiADH61747; ADH61747; Tmath_2073
KEGGitmt:Tmath_2073

Similar proteinsi

Entry informationi

Entry nameiD7ASV1_THEM3
AccessioniPrimary (citable) accession number: D7ASV1
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported