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D7ASJ1

- D7ASJ1_THEM3

UniProt

D7ASJ1 - D7ASJ1_THEM3

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Tmath_0443

Organism
Thermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781SubstrateUniRule annotation
Binding sitei110 – 1101SubstrateUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Sitei140 – 1401Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTMAT583358:GHOX-457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Tmath_0443Imported
OrganismiThermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
Taxonomic identifieri583358 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002064: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 1017Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiCVNTVET.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7ASJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGKIQMKVP LVEMDGDEMT RIIWKLIKEI LLEPYIDLKT EYYDLGIKNR
60 70 80 90 100
DETEDQVTID AAYAIKKYGV GVKCATITPN AQRVEEYHLK KMWKSPNGTI
110 120 130 140 150
RAILDGTVFR APIIVSSIKP LVKTWKKPIT IARHAYGDIY KDVEYRIENR
160 170 180 190 200
GKAELVFTSE TGEVSRQTIH EFEGPGVILG MHNTDESIKS FARACFNYAL
210 220 230 240 250
DTKQDLWFAT KDTISKTYDH RFKDIFQEIY ENEYKEKFEE AGIEYFYTLI
260 270 280 290 300
DDAVARIIRS EGGMIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPDGK
310 320 330 340 350
YEFEAAHGTV TRHYYKYLKG EETSTNSIAT IFAWTGALKK RGELDGIDSL
360 370 380 390 400
VDFADKLEKA SLQTIEKGIM TKDLAALSDL PNKIVVNTES FLLEIKKNLE

EII
Length:403
Mass (Da):45,894
Last modified:August 10, 2010 - v1
Checksum:i8E9169A8DA3BB947
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60215.1.
RefSeqiYP_003676226.1. NC_014209.1.

Genome annotation databases

EnsemblBacteriaiADH60215; ADH60215; Tmath_0443.
GeneIDi9241920.
KEGGitmt:Tmath_0443.
PATRICi38278938. VBITheMat18_0455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60215.1 .
RefSeqi YP_003676226.1. NC_014209.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH60215 ; ADH60215 ; Tmath_0443 .
GeneIDi 9241920.
KEGGi tmt:Tmath_0443.
PATRICi 38278938. VBITheMat18_0455.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi CVNTVET.

Enzyme and pathway databases

BioCyci TMAT583358:GHOX-457-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11426 / CIP 108742 / A3Imported.

Entry informationi

Entry nameiD7ASJ1_THEM3
AccessioniPrimary (citable) accession number: D7ASJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3