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D7ASJ1

- D7ASJ1_THEM3

UniProt

D7ASJ1 - D7ASJ1_THEM3

Protein

Isocitrate dehydrogenase [NADP]

Gene

Tmath_0443

Organism
Thermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781SubstrateUniRule annotation
    Binding sitei110 – 1101SubstrateUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Sitei140 – 1401Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTMAT583358:GHOX-457-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Tmath_0443Imported
    OrganismiThermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
    Taxonomic identifieri583358 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
    ProteomesiUP000002064: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 1017Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiCVNTVET.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D7ASJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGKIQMKVP LVEMDGDEMT RIIWKLIKEI LLEPYIDLKT EYYDLGIKNR    50
    DETEDQVTID AAYAIKKYGV GVKCATITPN AQRVEEYHLK KMWKSPNGTI 100
    RAILDGTVFR APIIVSSIKP LVKTWKKPIT IARHAYGDIY KDVEYRIENR 150
    GKAELVFTSE TGEVSRQTIH EFEGPGVILG MHNTDESIKS FARACFNYAL 200
    DTKQDLWFAT KDTISKTYDH RFKDIFQEIY ENEYKEKFEE AGIEYFYTLI 250
    DDAVARIIRS EGGMIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPDGK 300
    YEFEAAHGTV TRHYYKYLKG EETSTNSIAT IFAWTGALKK RGELDGIDSL 350
    VDFADKLEKA SLQTIEKGIM TKDLAALSDL PNKIVVNTES FLLEIKKNLE 400
    EII 403
    Length:403
    Mass (Da):45,894
    Last modified:August 10, 2010 - v1
    Checksum:i8E9169A8DA3BB947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002032 Genomic DNA. Translation: ADH60215.1.
    RefSeqiYP_003676226.1. NC_014209.1.

    Genome annotation databases

    EnsemblBacteriaiADH60215; ADH60215; Tmath_0443.
    GeneIDi9241920.
    KEGGitmt:Tmath_0443.
    PATRICi38278938. VBITheMat18_0455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002032 Genomic DNA. Translation: ADH60215.1 .
    RefSeqi YP_003676226.1. NC_014209.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADH60215 ; ADH60215 ; Tmath_0443 .
    GeneIDi 9241920.
    KEGGi tmt:Tmath_0443.
    PATRICi 38278938. VBITheMat18_0455.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi CVNTVET.

    Enzyme and pathway databases

    BioCyci TMAT583358:GHOX-457-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 11426 / CIP 108742 / A3Imported.

    Entry informationi

    Entry nameiD7ASJ1_THEM3
    AccessioniPrimary (citable) accession number: D7ASJ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3