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D7ASJ1 (D7ASJ1_THEM3) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region95 – 1017Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site781Substrate By similarity PIRSR PIRSR000108-2
Binding site1101Substrate By similarity PIRSR PIRSR000108-2
Binding site1331Substrate By similarity PIRSR PIRSR000108-2
Site1401Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
D7ASJ1 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 8E9169A8DA3BB947

FASTA40345,894
        10         20         30         40         50         60 
MIGKIQMKVP LVEMDGDEMT RIIWKLIKEI LLEPYIDLKT EYYDLGIKNR DETEDQVTID 

        70         80         90        100        110        120 
AAYAIKKYGV GVKCATITPN AQRVEEYHLK KMWKSPNGTI RAILDGTVFR APIIVSSIKP 

       130        140        150        160        170        180 
LVKTWKKPIT IARHAYGDIY KDVEYRIENR GKAELVFTSE TGEVSRQTIH EFEGPGVILG 

       190        200        210        220        230        240 
MHNTDESIKS FARACFNYAL DTKQDLWFAT KDTISKTYDH RFKDIFQEIY ENEYKEKFEE 

       250        260        270        280        290        300 
AGIEYFYTLI DDAVARIIRS EGGMIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPDGK 

       310        320        330        340        350        360 
YEFEAAHGTV TRHYYKYLKG EETSTNSIAT IFAWTGALKK RGELDGIDSL VDFADKLEKA 

       370        380        390        400 
SLQTIEKGIM TKDLAALSDL PNKIVVNTES FLLEIKKNLE EII 

« Hide

References

[1]"Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 11426 / CIP 108742 / A3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002032 Genomic DNA. Translation: ADH60215.1.
RefSeqYP_003676226.1. NC_014209.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADH60215; ADH60215; Tmath_0443.
GeneID9241920.
KEGGtmt:Tmath_0443.
PATRIC38278938. VBITheMat18_0455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycTMAT583358:GHOX-457-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD7ASJ1_THEM3
AccessionPrimary (citable) accession number: D7ASJ1
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)