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D7ASJ1

- D7ASJ1_THEM3

UniProt

D7ASJ1 - D7ASJ1_THEM3

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Tmath_0443
Organism
Thermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Substrate By similarityUniRule annotation
Binding sitei110 – 1101Substrate By similarityUniRule annotation
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Sitei140 – 1401Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarity
Metal bindingi274 – 2741Magnesium or manganese By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTMAT583358:GHOX-457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Tmath_0443Imported
OrganismiThermoanaerobacter mathranii (strain DSM 11426 / CIP 108742 / A3)Imported
Taxonomic identifieri583358 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeThermoanaerobacter
ProteomesiUP000002064: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 1017Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiCVNTVET.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D7ASJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MIGKIQMKVP LVEMDGDEMT RIIWKLIKEI LLEPYIDLKT EYYDLGIKNR    50
DETEDQVTID AAYAIKKYGV GVKCATITPN AQRVEEYHLK KMWKSPNGTI 100
RAILDGTVFR APIIVSSIKP LVKTWKKPIT IARHAYGDIY KDVEYRIENR 150
GKAELVFTSE TGEVSRQTIH EFEGPGVILG MHNTDESIKS FARACFNYAL 200
DTKQDLWFAT KDTISKTYDH RFKDIFQEIY ENEYKEKFEE AGIEYFYTLI 250
DDAVARIIRS EGGMIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPDGK 300
YEFEAAHGTV TRHYYKYLKG EETSTNSIAT IFAWTGALKK RGELDGIDSL 350
VDFADKLEKA SLQTIEKGIM TKDLAALSDL PNKIVVNTES FLLEIKKNLE 400
EII 403
Length:403
Mass (Da):45,894
Last modified:August 10, 2010 - v1
Checksum:i8E9169A8DA3BB947
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60215.1.
RefSeqiYP_003676226.1. NC_014209.1.

Genome annotation databases

EnsemblBacteriaiADH60215; ADH60215; Tmath_0443.
GeneIDi9241920.
KEGGitmt:Tmath_0443.
PATRICi38278938. VBITheMat18_0455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002032 Genomic DNA. Translation: ADH60215.1 .
RefSeqi YP_003676226.1. NC_014209.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH60215 ; ADH60215 ; Tmath_0443 .
GeneIDi 9241920.
KEGGi tmt:Tmath_0443.
PATRICi 38278938. VBITheMat18_0455.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi CVNTVET.

Enzyme and pathway databases

BioCyci TMAT583358:GHOX-457-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Thermoanaerobacter mathranii subsp. mathranii mathranii str. A3."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Held B., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Zhou J., Hemme C., Woyke T.
    Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 11426 / CIP 108742 / A3.

Entry informationi

Entry nameiD7ASJ1_THEM3
AccessioniPrimary (citable) accession number: D7ASJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi