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Protein

Alanine racemase

Gene

Snov_1077

Organism
Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Snov_1077)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Active sitei261Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei314Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSNOV639283:G1GLM-1082-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Snov_1077Imported
OrganismiStarkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)Imported
Taxonomic identifieri639283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeStarkeya
Proteomesi
  • UP000006633 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi639283.Snov_1077

Structurei

3D structure databases

ProteinModelPortaliD7A723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 371Ala_racemase_CInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiCALHVDT
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D7A723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRDIPLNE AGGVLTIDLS ALAANFRDVA ARVAPAKCAA VVKGDAYGLG
60 70 80 90 100
LVPTASTLWH AGARTFFVAL LSEARKLREL LPDAEIFVLN GLFPGTEATY
110 120 130 140 150
QQHALLPVLG SVPEIERWQQ FCERTGEPLP AALHVDTGMN RLGLSAAEAV
160 170 180 190 200
NVAEGRDELG FPLALLMSHL ACADEPGHPL TDRQLEDFQA IVALFPDVRA
210 220 230 240 250
SLANSAGALG DPSLHFDLVR PGIAVYGARP RADVAPLQPV VRLDLRIVQI
260 270 280 290 300
RRVHEGETIG YGAAHTAKRE SRVAILSAGY ADGIPRLASA SDLRPGAEAV
310 320 330 340 350
VGGHRCPLIG RISMDLLAVD ITDVDEDAVA AGDFATLLGD GLALEDLARH
360 370
SATIDYEILT SLGRRYHRRW VQGA
Length:374
Mass (Da):39,853
Last modified:August 10, 2010 - v1
Checksum:i80162263940469A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002026 Genomic DNA Translation: ADH88397.1
RefSeqiWP_013165902.1, NC_014217.1

Genome annotation databases

EnsemblBacteriaiADH88397; ADH88397; Snov_1077
KEGGisno:Snov_1077

Similar proteinsi

Entry informationi

Entry nameiD7A723_STAND
AccessioniPrimary (citable) accession number: D7A723
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health