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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128Substrate; in homodimeric partnerUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1
Binding sitei182SubstrateUniRule annotation1
Metal bindingi206Magnesium; via carbamate groupUniRule annotation1
Metal bindingi208MagnesiumUniRule annotation1
Metal bindingi209MagnesiumUniRule annotation1
Active sitei298Proton acceptorUniRule annotation1
Binding sitei299SubstrateUniRule annotation1
Binding sitei331SubstrateUniRule annotation1
Sitei338Transition state stabilizerUniRule annotation1
Binding sitei383SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase
Biological processCalvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
Ordered Locus Names:Snov_0428Imported
OrganismiStarkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)Imported
Taxonomic identifieri639283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeStarkeya
Proteomesi
  • UP000006633 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206N6-carboxylysineUniRule annotation1

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Protein-protein interaction databases

STRINGi639283.Snov_0428.

Structurei

3D structure databases

ProteinModelPortaliD7A343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 149RuBisCO_large_NInterPro annotationAdd BLAST121
Domaini159 – 466RuBisCO_largeInterPro annotationAdd BLAST308

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DT1. Bacteria.
COG1850. LUCA.
HOGENOMiHOG000230831.
KOiK01601.
OMAiHRAMHAA.
OrthoDBiPOG091H14UZ.

Family and domain databases

CDDicd08212. RuBisCO_large_I. 1 hit.
Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1. 1 hit.
InterProiView protein in InterPro
IPR033966. RuBisCO.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR036376. RuBisCO_lsu_C_sf.
IPR017443. RuBisCO_lsu_fd_N.
IPR036422. RuBisCO_lsu_N_sf.
IPR020888. RuBisCO_lsuI.
PfamiView protein in Pfam
PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
SFLDiSFLDS00014. RuBisCO. 1 hit.
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiView protein in PROSITE
PS00157. RUBISCO_LARGE. 1 hit.

Sequencei

Sequence statusi: Complete.

D7A343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIDKTASA DKPRSRYSAG VMEYRKMGYW QPDYEPKDTD VIALFRVTPQ
60 70 80 90 100
DGVDPIEASA AVAGESSTAT WTVVWTDRLT ACDKYRAKCY RVDPVPNSPG
110 120 130 140 150
SWFAYIAYDL DLFEPGSISN LSASIIGNVF GFKPLKALRL EDMRLPVAYV
160 170 180 190 200
KTFDGPATGI VVERERLDKF GRPLLGATVK PKLGLSGRNY GRVVYEALKG
210 220 230 240 250
GLDFTKDDEN INSQPFMHWR ERFLYCMEAV NKAQASTGEI KGTYLNVTAG
260 270 280 290 300
TMEDMYERAD FAKSLGSNIV MIDLVIGYTA IQSMAKWARR NDMILHLHRA
310 320 330 340 350
GHSTYTRQKS HGVSFRVIAK WMRLAGVDHI HAGTVVGKLE GDPHTTKGYY
360 370 380 390 400
DICRDDFVPQ NLAHGVFFDQ DWASTRKLMP VASGGIHAGQ MHQLIDLLGE
410 420 430 440 450
DVVLQFGGGT IGHPMGIQAG ATANRVALEC MILARNEGRD ILAEGPDILN
460 470 480
EAARHCMPLK QALETWKDVT FNYSSTDTPD FVPQATAAE
Length:489
Mass (Da):54,138
Last modified:August 10, 2010 - v1
Checksum:iF62FCB0F0878F040
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002026 Genomic DNA. Translation: ADH87761.1.
RefSeqiWP_013165266.1. NC_014217.1.

Genome annotation databases

EnsemblBacteriaiADH87761; ADH87761; Snov_0428.
KEGGisno:Snov_0428.

Similar proteinsi

Entry informationi

Entry nameiD7A343_STAND
AccessioniPrimary (citable) accession number: D7A343
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 25, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported