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D6ZQA9 (D6ZQA9_STRP0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase HAMAP-Rule MF_00049
EC=6.1.1.4 HAMAP-Rule MF_00049
Alternative name(s):
Leucyl-tRNA synthetase HAMAP-Rule MF_00049
Gene names
Name:leuS HAMAP-Rule MF_00049
Ordered Locus Names:HMPREF0837_10570
OrganismStreptococcus pneumoniae serotype A19 (strain TCH8431) [Complete proteome] [HAMAP] EMBL ADI68798.1
Taxonomic identifier525381 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length833 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00049 RuleBase RU003489

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif41 – 5212"HIGH" region By similarity HAMAP-Rule MF_00049
Motif610 – 6145"KMSKS" region By similarity HAMAP-Rule MF_00049

Sites

Binding site6131ATP By similarity HAMAP-Rule MF_00049

Sequences

Sequence LengthMass (Da)Tools
D6ZQA9 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 2664352ED14EB01C

FASTA83394,413
        10         20         30         40         50         60 
MSFYNHKEIE PKWQGYWAEH HTFKTGTDAS KPKFYALDMF PYPSGAGLHV GHPEGYTATD 

        70         80         90        100        110        120 
ILSRYKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPAEF TAENIANFKR QINALGFSYD 

       130        140        150        160        170        180 
WDREVNTTDP NYYKWTQWIF TKLYEKGLAY EAEVPVNWVE ELGTAIANEE VLPDGTSERG 

       190        200        210        220        230        240 
GYPVVRKPMR QWMLKITAYA ERLLNDLDEL DWSESIKDMQ RNWIGKSTGA NVTFKVKGTD 

       250        260        270        280        290        300 
KEFTVFTTRP DTLFGATFTV LAPEHELVDA ITSSEQAEAV ADYKHQASLK SDLVRTDLAK 

       310        320        330        340        350        360 
EKTGVWTGAY AINPVNGKEM PIWIADYVLA SYGTGAVMAV PAHDQRDWEF AKQFDLPIVE 

       370        380        390        400        410        420 
VLEGGNVEEA AYTEDGLHVN SDFLDGLNKE DAIAKIVAYL EEKGCGQEKV TYRLRDWLFS 

       430        440        450        460        470        480 
RQRYWGEPIP IIHWEDGTST AVPETELPLV LPVTKDIRPS GTGESPLANL TDWLEVTRED 

       490        500        510        520        530        540 
GVKGRRETNT MPQWAGSSWY YLRYIDPHNT EKLADEDLLK QWLPVDIYVG GAEHAVLHLL 

       550        560        570        580        590        600 
YARFWHKFLY DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVTTDKVEK RDGSFFHVET 

       610        620        630        640        650        660 
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS EEGLEGSRKF 

       670        680        690        700        710        720 
LDRVYRLITS KEILAENNGA LDKAYNETVK AVTEQIESLK FNTAIAQLMV FVNAANKEDK 

       730        740        750        760        770        780 
LYIDYAKGFI QLIAPFAPHL AEELWQTVAE TGESISYVAW PTWDESKLVE DEIEIVVQIK 

       790        800        810        820        830 
GKVRAKLMVA KDLSREELQE IALADEKVKA EIDGKEIVKV IAVPNKLVNI VVK

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001993 Genomic DNA. Translation: ADI68798.1.
RefSeqYP_003724012.1. NC_014251.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI68798; ADI68798; HMPREF0837_10570.
GeneID9343824.
KEGGsnc:HMPREF0837_10570.
PATRIC38262831. VBIStrPne36006_0559.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000200748.
KOK01869.
OMAWIFLQIF.

Family and domain databases

Gene3D3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. tRNAsyn_1a_bind. 1 hit.
SSF50677. ValRS_IleRS_edit. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6ZQA9_STRP0
AccessionPrimary (citable) accession number: D6ZQA9
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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