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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei613ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
Ordered Locus Names:HMPREF0837_10570Imported
OrganismiStreptococcus pneumoniae serotype A19 (strain TCH8431)Imported
Taxonomic identifieri525381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000009083 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 165tRNA-synt_1gInterPro annotationAdd BLAST126
Domaini221 – 400tRNA-synt_1_2InterPro annotationAdd BLAST180
Domaini609 – 636tRNA-synt_1InterPro annotationAdd BLAST28
Domaini684 – 794Anticodon_1InterPro annotationAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi610 – 614"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

D6ZQA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFYNHKEIE PKWQGYWAEH HTFKTGTDAS KPKFYALDMF PYPSGAGLHV
60 70 80 90 100
GHPEGYTATD ILSRYKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPAEF
110 120 130 140 150
TAENIANFKR QINALGFSYD WDREVNTTDP NYYKWTQWIF TKLYEKGLAY
160 170 180 190 200
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA
210 220 230 240 250
ERLLNDLDEL DWSESIKDMQ RNWIGKSTGA NVTFKVKGTD KEFTVFTTRP
260 270 280 290 300
DTLFGATFTV LAPEHELVDA ITSSEQAEAV ADYKHQASLK SDLVRTDLAK
310 320 330 340 350
EKTGVWTGAY AINPVNGKEM PIWIADYVLA SYGTGAVMAV PAHDQRDWEF
360 370 380 390 400
AKQFDLPIVE VLEGGNVEEA AYTEDGLHVN SDFLDGLNKE DAIAKIVAYL
410 420 430 440 450
EEKGCGQEKV TYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPETELPLV
460 470 480 490 500
LPVTKDIRPS GTGESPLANL TDWLEVTRED GVKGRRETNT MPQWAGSSWY
510 520 530 540 550
YLRYIDPHNT EKLADEDLLK QWLPVDIYVG GAEHAVLHLL YARFWHKFLY
560 570 580 590 600
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVTTDKVEK RDGSFFHVET
610 620 630 640 650
GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS
660 670 680 690 700
EEGLEGSRKF LDRVYRLITS KEILAENNGA LDKAYNETVK AVTEQIESLK
710 720 730 740 750
FNTAIAQLMV FVNAANKEDK LYIDYAKGFI QLIAPFAPHL AEELWQTVAE
760 770 780 790 800
TGESISYVAW PTWDESKLVE DEIEIVVQIK GKVRAKLMVA KDLSREELQE
810 820 830
IALADEKVKA EIDGKEIVKV IAVPNKLVNI VVK
Length:833
Mass (Da):94,413
Last modified:August 10, 2010 - v1
Checksum:i2664352ED14EB01C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001993 Genomic DNA Translation: ADI68798.1
RefSeqiWP_000011769.1, NC_014251.1

Genome annotation databases

EnsemblBacteriaiADI68798; ADI68798; HMPREF0837_10570
KEGGisnc:HMPREF0837_10570

Similar proteinsi

Entry informationi

Entry nameiD6ZQA9_STRP0
AccessioniPrimary (citable) accession number: D6ZQA9
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 20, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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