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D6ZLV0

- D6ZLV0_STRP0

UniProt

D6ZLV0 - D6ZLV0_STRP0

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Protein
DNA topoisomerase 4 subunit A
Gene
parC, HMPREF0837_11636
Organism
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 381Interaction with DNA By similarityUniRule annotation
Sitei74 – 741Interaction with DNA By similarityUniRule annotation
Sitei76 – 761Interaction with DNA By similarityUniRule annotation
Sitei87 – 871Interaction with DNA By similarityUniRule annotation
Sitei93 – 931Interaction with DNA By similarityUniRule annotation
Sitei117 – 1171Transition state stabilizer By similarityUniRule annotation
Active sitei118 – 1181O-(5'-phospho-DNA)-tyrosine intermediate By similarityUniRule annotation
Metal bindingi316 – 3161Magnesium; via carbonyl oxygenImported
Metal bindingi319 – 3191Magnesium; via carbonyl oxygenImported
Metal bindingi322 – 3221Magnesium; via carbonyl oxygenImported

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA topological change Source: UniProtKB-HAMAP
  2. chromosome segregation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, MagnesiumImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciSPNE525381:GH2H-1675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit A
Gene namesi
Name:parCUniRule annotationImported
Ordered Locus Names:HMPREF0837_11636Imported
OrganismiStreptococcus pneumoniae serotype A19 (strain TCH8431)Imported
Taxonomic identifieri525381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009083: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE By similarity.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I3HX-ray3.70A/B1-488[»]

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076279.
KOiK02621.
OMAiHIVEGLM.
OrthoDBiEOG661H5V.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPiMF_00937. ParC_type2.
InterProiIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamiPF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTiSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMiSSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

Sequencei

Sequence statusi: Complete.

D6ZLV0-1 [UniParc]FASTAAdd to Basket

« Hide

MSNIQNMSLE DIMGERFGRY SKYIIQDRAL PDIRDGLKPV QRRILYSMNK    50
DSNTFDKSYR KSAKSVGNIM GNFHPHGDSS IYDAMVRMSQ NWKNREILVE 100
MHGNNGSMDG DPPAAMRYTE ARLSEIAGYL LQDIEKKTVP FAWNFDDTEK 150
EPTVLPAAFP NLLVNGSTGI SAGYATDIPP HNLAEVIDAA VYMIDHPTAK 200
IDKLMEFLPG PDFPTGAIIQ GRDEIKKAYE TGKGRVVVRS KTEIEKLKGG 250
KEQIVITEIP YEINKANLVK KIDDVRVNNK VAGIAEVRDE SDRDGLRIAI 300
ELKKDANTEL VLNYLFKYTD LQINYNFNMV AIDNFTPRQV GIVPILSSYI 350
AHRREVILAR SRFDKEKAEK RLHIVEGLIR VISILDEVIA LIRASENKAD 400
AKENLKVSYD FTEEQAEAIV TLQLYRLTNT DVVVLQEEEA ELREKIAMLA 450
AIIGDERTMY NLMKKELREV KKKFATPRLS SLEDTAKAIE IDTASLIAEE 500
DTYVSVTKAG YIKRTSPRSF AASTLEEIGK RDDDRLIFVQ SAKTTQHLLM 550
FTSLGNVIYR PIHELADIRW KDIGEHLSQT ITNFETNEEI LYVEVLDQFD 600
DATTYFAVTR LGQIKRVERK EFTPWRTYRS KSVKYAKLKD DTDQIVAVAP 650
IKLDDVVLVS QNGYALRFNI EEVPVVGAKA AGVKAMNLKE DDVLQSGFIC 700
NTSSFYLLTQ RGSLKRVSIE EILATSRAKR GLQVLRELKN KPHRVFLAGA 750
VAEQGFVGDF FSTEVDVNDQ TLLVQSNKGT IYESRLQDLN LSERTSNGSF 800
ISDTISDEEV FDAYLQEVVT EDK 823
Length:823
Mass (Da):93,121
Last modified:August 10, 2010 - v1
Checksum:iC22985D323D63A62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001993 Genomic DNA. Translation: ADI69864.1.
RefSeqiYP_003725078.1. NC_014251.1.

Genome annotation databases

EnsemblBacteriaiADI69864; ADI69864; HMPREF0837_11636.
GeneIDi9344899.
KEGGisnc:HMPREF0837_11636.
PATRICi38264973. VBIStrPne36006_1622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001993 Genomic DNA. Translation: ADI69864.1 .
RefSeqi YP_003725078.1. NC_014251.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I3H X-ray 3.70 A/B 1-488 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI69864 ; ADI69864 ; HMPREF0837_11636 .
GeneIDi 9344899.
KEGGi snc:HMPREF0837_11636.
PATRICi 38264973. VBIStrPne36006_1622.

Phylogenomic databases

HOGENOMi HOG000076279.
KOi K02621.
OMAi HIVEGLM.
OrthoDBi EOG661H5V.

Enzyme and pathway databases

BioCyci SPNE525381:GH2H-1675-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPi MF_00937. ParC_type2.
InterProi IPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view ]
Pfami PF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view ]
SMARTi SM00434. TOP4c. 1 hit.
[Graphical view ]
SUPFAMi SSF56719. SSF56719. 1 hit.
TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A catalog of reference genomes from the human microbiome."
    Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C., Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E., Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R., Ward D.V., Birren B.W., Gibbs R.A., Methe B.
    , Petrosino J.F., Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S., Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T., Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C., Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J., McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M., Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J., Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L., Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C., Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M., Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M., Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N., Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.
    Science 328:994-999(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCH8431.
  2. "Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport."
    Laponogov I., Veselkov D.A., Crevel I.M., Pan X.S., Fisher L.M., Sanderson M.R.
    Nucleic Acids Res. 41:9911-9923(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 1-488 IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiD6ZLV0_STRP0
AccessioniPrimary (citable) accession number: D6ZLV0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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