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D6ZLV0

- D6ZLV0_STRP0

UniProt

D6ZLV0 - D6ZLV0_STRP0

Protein

DNA topoisomerase 4 subunit A

Gene

parC

Organism
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 381Interaction with DNAUniRule annotation
    Sitei74 – 741Interaction with DNAUniRule annotation
    Sitei76 – 761Interaction with DNAUniRule annotation
    Sitei87 – 871Interaction with DNAUniRule annotation
    Sitei93 – 931Interaction with DNAUniRule annotation
    Sitei117 – 1171Transition state stabilizerUniRule annotation
    Active sitei118 – 1181O-(5'-phospho-DNA)-tyrosine intermediateUniRule annotation
    Metal bindingi316 – 3161Magnesium; via carbonyl oxygenImported
    Metal bindingi319 – 3191Magnesium; via carbonyl oxygenImported
    Metal bindingi322 – 3221Magnesium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-HAMAP
    2. DNA topological change Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, MagnesiumImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciSPNE525381:GH2H-1675-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA topoisomerase 4 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Topoisomerase IV subunit AUniRule annotation
    Gene namesi
    Name:parCUniRule annotationImported
    Ordered Locus Names:HMPREF0837_11636Imported
    OrganismiStreptococcus pneumoniae serotype A19 (strain TCH8431)Imported
    Taxonomic identifieri525381 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000009083: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: InterPro
    2. extrinsic component of plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    Heterotetramer composed of ParC and ParE.UniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I3HX-ray3.70A/B1-488[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076279.
    KOiK02621.
    OMAiHIVEGLM.
    OrthoDBiEOG661H5V.

    Family and domain databases

    Gene3Di3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPiMF_00937. ParC_type2.
    InterProiIPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view]
    PfamiPF03989. DNA_gyraseA_C. 5 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view]
    SMARTiSM00434. TOP4c. 1 hit.
    [Graphical view]
    SUPFAMiSSF56719. SSF56719. 1 hit.
    TIGRFAMsiTIGR01061. parC_Gpos. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D6ZLV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNIQNMSLE DIMGERFGRY SKYIIQDRAL PDIRDGLKPV QRRILYSMNK    50
    DSNTFDKSYR KSAKSVGNIM GNFHPHGDSS IYDAMVRMSQ NWKNREILVE 100
    MHGNNGSMDG DPPAAMRYTE ARLSEIAGYL LQDIEKKTVP FAWNFDDTEK 150
    EPTVLPAAFP NLLVNGSTGI SAGYATDIPP HNLAEVIDAA VYMIDHPTAK 200
    IDKLMEFLPG PDFPTGAIIQ GRDEIKKAYE TGKGRVVVRS KTEIEKLKGG 250
    KEQIVITEIP YEINKANLVK KIDDVRVNNK VAGIAEVRDE SDRDGLRIAI 300
    ELKKDANTEL VLNYLFKYTD LQINYNFNMV AIDNFTPRQV GIVPILSSYI 350
    AHRREVILAR SRFDKEKAEK RLHIVEGLIR VISILDEVIA LIRASENKAD 400
    AKENLKVSYD FTEEQAEAIV TLQLYRLTNT DVVVLQEEEA ELREKIAMLA 450
    AIIGDERTMY NLMKKELREV KKKFATPRLS SLEDTAKAIE IDTASLIAEE 500
    DTYVSVTKAG YIKRTSPRSF AASTLEEIGK RDDDRLIFVQ SAKTTQHLLM 550
    FTSLGNVIYR PIHELADIRW KDIGEHLSQT ITNFETNEEI LYVEVLDQFD 600
    DATTYFAVTR LGQIKRVERK EFTPWRTYRS KSVKYAKLKD DTDQIVAVAP 650
    IKLDDVVLVS QNGYALRFNI EEVPVVGAKA AGVKAMNLKE DDVLQSGFIC 700
    NTSSFYLLTQ RGSLKRVSIE EILATSRAKR GLQVLRELKN KPHRVFLAGA 750
    VAEQGFVGDF FSTEVDVNDQ TLLVQSNKGT IYESRLQDLN LSERTSNGSF 800
    ISDTISDEEV FDAYLQEVVT EDK 823
    Length:823
    Mass (Da):93,121
    Last modified:August 10, 2010 - v1
    Checksum:iC22985D323D63A62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001993 Genomic DNA. Translation: ADI69864.1.
    RefSeqiYP_003725078.1. NC_014251.1.

    Genome annotation databases

    EnsemblBacteriaiADI69864; ADI69864; HMPREF0837_11636.
    GeneIDi9344899.
    KEGGisnc:HMPREF0837_11636.
    PATRICi38264973. VBIStrPne36006_1622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001993 Genomic DNA. Translation: ADI69864.1 .
    RefSeqi YP_003725078.1. NC_014251.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I3H X-ray 3.70 A/B 1-488 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI69864 ; ADI69864 ; HMPREF0837_11636 .
    GeneIDi 9344899.
    KEGGi snc:HMPREF0837_11636.
    PATRICi 38264973. VBIStrPne36006_1622.

    Phylogenomic databases

    HOGENOMi HOG000076279.
    KOi K02621.
    OMAi HIVEGLM.
    OrthoDBi EOG661H5V.

    Enzyme and pathway databases

    BioCyci SPNE525381:GH2H-1675-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.40. 1 hit.
    3.90.199.10. 2 hits.
    HAMAPi MF_00937. ParC_type2.
    InterProi IPR024946. Arg_repress_C-like.
    IPR006691. GyrA/parC_pinwhl.
    IPR002205. Topo_IIA_A/C.
    IPR013758. Topo_IIA_A/C_ab.
    IPR013760. Topo_IIA_like_dom.
    IPR005741. TopoIV_A_Gpos.
    [Graphical view ]
    Pfami PF03989. DNA_gyraseA_C. 5 hits.
    PF00521. DNA_topoisoIV. 1 hit.
    [Graphical view ]
    SMARTi SM00434. TOP4c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56719. SSF56719. 1 hit.
    TIGRFAMsi TIGR01061. parC_Gpos. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A catalog of reference genomes from the human microbiome."
      Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C., Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E., Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R., Ward D.V., Birren B.W., Gibbs R.A., Methe B.
      , Petrosino J.F., Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S., Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T., Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C., Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J., McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M., Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J., Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L., Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C., Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M., Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M., Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N., Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.
      Science 328:994-999(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCH8431Imported.
    2. "Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport."
      Laponogov I., Veselkov D.A., Crevel I.M., Pan X.S., Fisher L.M., Sanderson M.R.
      Nucleic Acids Res. 41:9911-9923(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 1-488 IN COMPLEX WITH MAGNESIUM.

    Entry informationi

    Entry nameiD6ZLV0_STRP0
    AccessioniPrimary (citable) accession number: D6ZLV0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3