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D6ZLV0 (D6ZLV0_STRP0) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA topoisomerase 4 subunit A HAMAP-Rule MF_00937

EC=5.99.1.3 HAMAP-Rule MF_00937
Alternative name(s):
Topoisomerase IV subunit A HAMAP-Rule MF_00937
Gene names
Name:parC HAMAP-Rule MF_00937 EMBL ADI69864.1
Ordered Locus Names:HMPREF0837_11636 EMBL ADI69864.1
OrganismStreptococcus pneumoniae serotype A19 (strain TCH8431) [Complete proteome] [HAMAP] EMBL ADI69864.1
Taxonomic identifier525381 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length823 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity. HAMAP-Rule MF_00937

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00937 SAAS SAAS006691

Subunit structure

Heterotetramer composed of ParC and ParE By similarity. HAMAP-Rule MF_00937

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00937.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. HAMAP-Rule MF_00937

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1181O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_00937
Metal binding3161Magnesium; via carbonyl oxygen PDB 4I3H
Metal binding3191Magnesium; via carbonyl oxygen PDB 4I3H
Metal binding3221Magnesium; via carbonyl oxygen PDB 4I3H
Site381Interaction with DNA By similarity HAMAP-Rule MF_00937
Site741Interaction with DNA By similarity HAMAP-Rule MF_00937
Site761Interaction with DNA By similarity HAMAP-Rule MF_00937
Site871Interaction with DNA By similarity HAMAP-Rule MF_00937
Site931Interaction with DNA By similarity HAMAP-Rule MF_00937
Site1171Transition state stabilizer By similarity HAMAP-Rule MF_00937

Sequences

Sequence LengthMass (Da)Tools
D6ZLV0 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: C22985D323D63A62

FASTA82393,121
        10         20         30         40         50         60 
MSNIQNMSLE DIMGERFGRY SKYIIQDRAL PDIRDGLKPV QRRILYSMNK DSNTFDKSYR 

        70         80         90        100        110        120 
KSAKSVGNIM GNFHPHGDSS IYDAMVRMSQ NWKNREILVE MHGNNGSMDG DPPAAMRYTE 

       130        140        150        160        170        180 
ARLSEIAGYL LQDIEKKTVP FAWNFDDTEK EPTVLPAAFP NLLVNGSTGI SAGYATDIPP 

       190        200        210        220        230        240 
HNLAEVIDAA VYMIDHPTAK IDKLMEFLPG PDFPTGAIIQ GRDEIKKAYE TGKGRVVVRS 

       250        260        270        280        290        300 
KTEIEKLKGG KEQIVITEIP YEINKANLVK KIDDVRVNNK VAGIAEVRDE SDRDGLRIAI 

       310        320        330        340        350        360 
ELKKDANTEL VLNYLFKYTD LQINYNFNMV AIDNFTPRQV GIVPILSSYI AHRREVILAR 

       370        380        390        400        410        420 
SRFDKEKAEK RLHIVEGLIR VISILDEVIA LIRASENKAD AKENLKVSYD FTEEQAEAIV 

       430        440        450        460        470        480 
TLQLYRLTNT DVVVLQEEEA ELREKIAMLA AIIGDERTMY NLMKKELREV KKKFATPRLS 

       490        500        510        520        530        540 
SLEDTAKAIE IDTASLIAEE DTYVSVTKAG YIKRTSPRSF AASTLEEIGK RDDDRLIFVQ 

       550        560        570        580        590        600 
SAKTTQHLLM FTSLGNVIYR PIHELADIRW KDIGEHLSQT ITNFETNEEI LYVEVLDQFD 

       610        620        630        640        650        660 
DATTYFAVTR LGQIKRVERK EFTPWRTYRS KSVKYAKLKD DTDQIVAVAP IKLDDVVLVS 

       670        680        690        700        710        720 
QNGYALRFNI EEVPVVGAKA AGVKAMNLKE DDVLQSGFIC NTSSFYLLTQ RGSLKRVSIE 

       730        740        750        760        770        780 
EILATSRAKR GLQVLRELKN KPHRVFLAGA VAEQGFVGDF FSTEVDVNDQ TLLVQSNKGT 

       790        800        810        820 
IYESRLQDLN LSERTSNGSF ISDTISDEEV FDAYLQEVVT EDK 

« Hide

References

« Hide 'large scale' references
[1]"A catalog of reference genomes from the human microbiome."
Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C., Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E., Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R., Ward D.V., Birren B.W., Gibbs R.A., Methe B. expand/collapse author list , Petrosino J.F., Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S., Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T., Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C., Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J., McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M., Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J., Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L., Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C., Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M., Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M., Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N., Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.
Science 328:994-999(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TCH8431.
[2]"Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport."
Laponogov I., Veselkov D.A., Crevel I.M., Pan X.S., Fisher L.M., Sanderson M.R.
Nucleic Acids Res. 41:9911-9923(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.70 ANGSTROMS) OF 1-488 IN COMPLEX WITH MAGNESIUM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001993 Genomic DNA. Translation: ADI69864.1.
RefSeqYP_003725078.1. NC_014251.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4I3HX-ray3.70A/B1-488[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI69864; ADI69864; HMPREF0837_11636.
GeneID9344899.
KEGGsnc:HMPREF0837_11636.
PATRIC38264973. VBIStrPne36006_1622.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000076279.
KOK02621.
OMAHIVEGLM.
OrthoDBEOG661H5V.

Enzyme and pathway databases

BioCycSPNE525381:GH2H-1675-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_00937. ParC_type2.
InterProIPR024946. Arg_repress_C-like.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
IPR005741. TopoIV_A_Gpos.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 5 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01061. parC_Gpos. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD6ZLV0_STRP0
AccessionPrimary (citable) accession number: D6ZLV0
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)