Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D6ZLN1 (D6ZLN1_STRP0) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Spermidine synthase RuleBase RU003837 HAMAP-Rule MF_00198

EC=2.5.1.16 RuleBase RU003837 HAMAP-Rule MF_00198
Alternative name(s):
Putrescine aminopropyltransferase HAMAP-Rule MF_00198
SPDSY HAMAP-Rule MF_00198
Gene names
Name:speE HAMAP-Rule MF_00198 EMBL ADI69795.1
Ordered Locus Names:HMPREF0837_11567 EMBL ADI69795.1
OrganismStreptococcus pneumoniae serotype A19 (strain TCH8431) [Complete proteome] [HAMAP] EMBL ADI69795.1
Taxonomic identifier525381 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor By similarity. HAMAP-Rule MF_00198

Catalytic activity

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine. RuleBase RU003837 HAMAP-Rule MF_00198

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. HAMAP-Rule MF_00198

Subunit structure

Homodimer or homotetramer By similarity. HAMAP-Rule MF_00198

Sequence similarities

Belongs to the spermidine/spermine synthase family. RuleBase RU003836 HAMAP-Rule MF_00198

Contains 1 PABS (polyamine biosynthesis) domain. HAMAP-Rule MF_00198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain2 – 237236PABS By similarity HAMAP-Rule MF_00198
Region137 – 1382S-adenosylmethioninamine binding By similarity HAMAP-Rule MF_00198

Sites

Active site1551Proton acceptor By similarity HAMAP-Rule MF_00198
Binding site311S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site611Putrescine By similarity HAMAP-Rule MF_00198
Binding site861S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1061S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1581Putrescine By similarity HAMAP-Rule MF_00198

Sequences

Sequence LengthMass (Da)Tools
D6ZLN1 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 2131961004F6917F

FASTA28632,859
        10         20         30         40         50         60 
MDLWFSEVHT PDVKLSLRTA KQLYAGKSEW QDIEVLDTPA FGKILILNGH VLFSDADDFV 

        70         80         90        100        110        120 
YNEMTVHVPM AVHPNPKKVL VIGGGDGGVA QVLTLYPELE QIDIVEPDEM LVEVCREYFP 

       130        140        150        160        170        180 
DFAAGLDDPR VTIYYQNGLR FLRNCEDDYD IIINDATDPF GHTEGLFTKE FYGNSYRALK 

       190        200        210        220        230        240 
EDGIMIYQHG SPFFDEDESA CRSMHRKVNQ AFPISRVYQA HIPTSPAGYW LFGFASKKYH 

       250        260        270        280 
PVKDFDKEGW KKRQLFTEYY TANLHVGAFM LPKYVEDILE EEEGKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001993 Genomic DNA. Translation: ADI69795.1.
RefSeqYP_003725009.1. NC_014251.1.

3D structure databases

ProteinModelPortalD6ZLN1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI69795; ADI69795; HMPREF0837_11567.
GeneID9344826.
KEGGsnc:HMPREF0837_11567.
PATRIC38264833. VBIStrPne36006_1555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000256146.
KOK00797.
OMACKTLFPV.
OrthoDBEOG644ZMH.

Enzyme and pathway databases

BioCycSPNE525381:GH2H-1602-MONOMER.
UniPathwayUPA00248; UER00314.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
HAMAPMF_00198. Spermidine_synth.
InterProIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERPTHR11558. PTHR11558. 1 hit.
PfamPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
TIGRFAMsTIGR00417. speE. 1 hit.
PROSITEPS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6ZLN1_STRP0
AccessionPrimary (citable) accession number: D6ZLN1
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)