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D6ZLN1

- D6ZLN1_STRP0

UniProt

D6ZLN1 - D6ZLN1_STRP0

Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

    Catalytic activityi

    S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71PolyamineUniRule annotation
    Binding sitei31 – 311S-adenosylmethioninamineUniRule annotation
    Binding sitei86 – 861PolyamineUniRule annotation
    Binding sitei106 – 1061S-adenosylmethioninamineUniRule annotation
    Active sitei155 – 1551Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. spermidine synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Keywords - Biological processi

    Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciSPNE525381:GH2H-1602-MONOMER.
    UniPathwayiUPA00248; UER00314.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyamine aminopropyl transferaseUniRule annotation
    Alternative name(s):
    Putrescine aminopropyltransferaseUniRule annotation
    Spermidine synthaseUniRule annotation
    Gene namesi
    Name:speEUniRule annotationImported
    Ordered Locus Names:HMPREF0837_11567Imported
    OrganismiStreptococcus pneumoniae serotype A19 (strain TCH8431)Imported
    Taxonomic identifieri525381 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000009083: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD6ZLN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 237236PABSUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1382S-adenosylmethioninamine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the spermidine/spermine synthase family.UniRule annotation
    Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000256146.
    KOiK00797.
    OMAiCKTLFPV.
    OrthoDBiEOG644ZMH.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_00198. Spermidine_synth.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view]
    PANTHERiPTHR11558. PTHR11558. 1 hit.
    PfamiPF01564. Spermine_synth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00417. speE. 1 hit.
    PROSITEiPS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6ZLN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLWFSEVHT PDVKLSLRTA KQLYAGKSEW QDIEVLDTPA FGKILILNGH    50
    VLFSDADDFV YNEMTVHVPM AVHPNPKKVL VIGGGDGGVA QVLTLYPELE 100
    QIDIVEPDEM LVEVCREYFP DFAAGLDDPR VTIYYQNGLR FLRNCEDDYD 150
    IIINDATDPF GHTEGLFTKE FYGNSYRALK EDGIMIYQHG SPFFDEDESA 200
    CRSMHRKVNQ AFPISRVYQA HIPTSPAGYW LFGFASKKYH PVKDFDKEGW 250
    KKRQLFTEYY TANLHVGAFM LPKYVEDILE EEEGKK 286
    Length:286
    Mass (Da):32,859
    Last modified:August 10, 2010 - v1
    Checksum:i2131961004F6917F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001993 Genomic DNA. Translation: ADI69795.1.
    RefSeqiYP_003725009.1. NC_014251.1.

    Genome annotation databases

    EnsemblBacteriaiADI69795; ADI69795; HMPREF0837_11567.
    GeneIDi9344826.
    KEGGisnc:HMPREF0837_11567.
    PATRICi38264833. VBIStrPne36006_1555.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001993 Genomic DNA. Translation: ADI69795.1 .
    RefSeqi YP_003725009.1. NC_014251.1.

    3D structure databases

    ProteinModelPortali D6ZLN1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI69795 ; ADI69795 ; HMPREF0837_11567 .
    GeneIDi 9344826.
    KEGGi snc:HMPREF0837_11567.
    PATRICi 38264833. VBIStrPne36006_1555.

    Phylogenomic databases

    HOGENOMi HOG000256146.
    KOi K00797.
    OMAi CKTLFPV.
    OrthoDBi EOG644ZMH.

    Enzyme and pathway databases

    UniPathwayi UPA00248 ; UER00314 .
    BioCyci SPNE525381:GH2H-1602-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_00198. Spermidine_synth.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view ]
    PANTHERi PTHR11558. PTHR11558. 1 hit.
    Pfami PF01564. Spermine_synth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00417. speE. 1 hit.
    PROSITEi PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A catalog of reference genomes from the human microbiome."
      Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C., Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E., Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R., Ward D.V., Birren B.W., Gibbs R.A., Methe B.
      , Petrosino J.F., Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S., Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T., Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C., Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J., McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M., Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J., Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L., Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C., Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M., Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M., Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N., Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.
      Science 328:994-999(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCH8431Imported.

    Entry informationi

    Entry nameiD6ZLN1_STRP0
    AccessioniPrimary (citable) accession number: D6ZLN1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3