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D6ZLN1

- D6ZLN1_STRP0

UniProt

D6ZLN1 - D6ZLN1_STRP0

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Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Streptococcus pneumoniae serotype A19 (strain TCH8431)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71PolyamineUniRule annotation
Binding sitei31 – 311S-adenosylmethioninamineUniRule annotation
Binding sitei86 – 861PolyamineUniRule annotation
Binding sitei106 – 1061S-adenosylmethioninamineUniRule annotation
Active sitei155 – 1551Proton acceptorUniRule annotation

GO - Molecular functioni

  1. spermidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciSPNE525381:GH2H-1602-MONOMER.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyl transferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferaseUniRule annotation
Spermidine synthaseUniRule annotation
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:HMPREF0837_11567Imported
OrganismiStreptococcus pneumoniae serotype A19 (strain TCH8431)Imported
Taxonomic identifieri525381 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000009083: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6ZLN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 237236PABSUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1382S-adenosylmethioninamine bindingUniRule annotation

Sequence similaritiesi

Belongs to the spermidine/spermine synthase family.UniRule annotation
Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000256146.
KOiK00797.
OMAiCKTLFPV.
OrthoDBiEOG644ZMH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERiPTHR11558. PTHR11558. 1 hit.
PfamiPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6ZLN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLWFSEVHT PDVKLSLRTA KQLYAGKSEW QDIEVLDTPA FGKILILNGH
60 70 80 90 100
VLFSDADDFV YNEMTVHVPM AVHPNPKKVL VIGGGDGGVA QVLTLYPELE
110 120 130 140 150
QIDIVEPDEM LVEVCREYFP DFAAGLDDPR VTIYYQNGLR FLRNCEDDYD
160 170 180 190 200
IIINDATDPF GHTEGLFTKE FYGNSYRALK EDGIMIYQHG SPFFDEDESA
210 220 230 240 250
CRSMHRKVNQ AFPISRVYQA HIPTSPAGYW LFGFASKKYH PVKDFDKEGW
260 270 280
KKRQLFTEYY TANLHVGAFM LPKYVEDILE EEEGKK
Length:286
Mass (Da):32,859
Last modified:August 10, 2010 - v1
Checksum:i2131961004F6917F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001993 Genomic DNA. Translation: ADI69795.1.
RefSeqiYP_003725009.1. NC_014251.1.

Genome annotation databases

EnsemblBacteriaiADI69795; ADI69795; HMPREF0837_11567.
GeneIDi9344826.
KEGGisnc:HMPREF0837_11567.
PATRICi38264833. VBIStrPne36006_1555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001993 Genomic DNA. Translation: ADI69795.1 .
RefSeqi YP_003725009.1. NC_014251.1.

3D structure databases

ProteinModelPortali D6ZLN1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI69795 ; ADI69795 ; HMPREF0837_11567 .
GeneIDi 9344826.
KEGGi snc:HMPREF0837_11567.
PATRICi 38264833. VBIStrPne36006_1555.

Phylogenomic databases

HOGENOMi HOG000256146.
KOi K00797.
OMAi CKTLFPV.
OrthoDBi EOG644ZMH.

Enzyme and pathway databases

UniPathwayi UPA00248 ; UER00314 .
BioCyci SPNE525381:GH2H-1602-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00198. Spermidine_synth.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view ]
PANTHERi PTHR11558. PTHR11558. 1 hit.
Pfami PF01564. Spermine_synth. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00417. speE. 1 hit.
PROSITEi PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A catalog of reference genomes from the human microbiome."
    Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C., Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E., Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R., Ward D.V., Birren B.W., Gibbs R.A., Methe B.
    , Petrosino J.F., Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S., Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T., Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C., Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J., McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M., Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J., Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L., Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C., Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M., Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M., Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N., Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.
    Science 328:994-999(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCH8431Imported.

Entry informationi

Entry nameiD6ZLN1_STRP0
AccessioniPrimary (citable) accession number: D6ZLN1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3