UniProtKB - D6ZJD8 (D6ZJD8_MOBCV)
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Protein
Uracil-DNA glycosylase
Gene
ung
Organism
Mobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)
Status
Functioni
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation
Catalytic activityi
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotationSAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 72 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- uracil DNA N-glycosylase activity Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | GlycosidaseImported, Hydrolase |
Biological process | DNA damage, DNA repairUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)Short name: UDGUniRule annotation |
Gene namesi | Name:ungUniRule annotationImported Ordered Locus Names:HMPREF0573_10518Imported |
Organismi | Mobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)Imported |
Taxonomic identifieri | 548479 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Actinomycetales › Actinomycetaceae › Mobiluncus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 219 | UDGInterPro annotationAdd BLAST | 163 |
Sequence similaritiesi
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationSAAS annotation
Phylogenomic databases
HOGENOMi | HOG000229528. |
KOi | K03648. |
OMAi | QANGLCF. |
OrthoDBi | POG091H03VL. |
Family and domain databases
CDDi | cd10027. UDG_F1. 1 hit. |
Gene3Di | 3.40.470.10. 1 hit. |
HAMAPi | MF_00148. UDG. 1 hit. |
InterProi | View protein in InterPro IPR002043. UDG_fam1. IPR018085. Ura-DNA_Glyclase_AS. IPR005122. Uracil-DNA_glycosylase-like. IPR036895. Uracil-DNA_glycosylase-like_sf. |
PANTHERi | PTHR11264. PTHR11264. 1 hit. |
Pfami | View protein in Pfam PF03167. UDG. 1 hit. |
SMARTi | View protein in SMART SM00986. UDG. 1 hit. |
SUPFAMi | SSF52141. SSF52141. 1 hit. |
TIGRFAMsi | TIGR00628. ung. 1 hit. |
PROSITEi | View protein in PROSITE PS00130. U_DNA_GLYCOSYLASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
D6ZJD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQTGEERGGL ERIMSPDWAQ VMAPVEGQIH AMGDFLRAEL AAGRGYFPAG
60 70 80 90 100
ENVFHAFQYP LERVKVLIVG QDPYPTPGHA MGLSFSVMSG TEIPRSLVNI
110 120 130 140 150
FKELHQDLGL PLPTSGDLRP WAEQGVMLLN RALTVQPGKP ASHRGRGWEA
160 170 180 190 200
ITEFAIRELA NHHAAQGLPL VAILWGADAR RTKEFMPHVP CLESVHPSPL
210 220 230
SASRGFFGSR PFSRANELLV AQSGQPVDWR LP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001992 Genomic DNA. Translation: ADI66837.1. |
RefSeqi | WP_004011513.1. NC_014246.1. |
Genome annotation databases
EnsemblBacteriai | ADI66837; ADI66837; HMPREF0573_10518. |
KEGGi | mcu:HMPREF0573_10518. |
Similar proteinsi
Entry informationi
Entry namei | D6ZJD8_MOBCV | |
Accessioni | D6ZJD8Primary (citable) accession number: D6ZJD8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 10, 2010 |
Last sequence update: | August 10, 2010 | |
Last modified: | March 28, 2018 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |