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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Mobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotationImported, Hydrolase

Keywords - Biological processi

DNA damage, DNA repairUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotationImported
Ordered Locus Names:HMPREF0573_10518Imported
OrganismiMobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)Imported
Taxonomic identifieri548479 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinomycetalesActinomycetaceaeMobiluncus
Proteomesi
  • UP000006742 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 219UDGInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000229528.
KOiK03648.
OMAiLKPMLGD.
OrthoDBiPOG091H03VL.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6ZJD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTGEERGGL ERIMSPDWAQ VMAPVEGQIH AMGDFLRAEL AAGRGYFPAG
60 70 80 90 100
ENVFHAFQYP LERVKVLIVG QDPYPTPGHA MGLSFSVMSG TEIPRSLVNI
110 120 130 140 150
FKELHQDLGL PLPTSGDLRP WAEQGVMLLN RALTVQPGKP ASHRGRGWEA
160 170 180 190 200
ITEFAIRELA NHHAAQGLPL VAILWGADAR RTKEFMPHVP CLESVHPSPL
210 220 230
SASRGFFGSR PFSRANELLV AQSGQPVDWR LP
Length:232
Mass (Da):25,485
Last modified:August 10, 2010 - v1
Checksum:iE3853EBA2A9A9AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001992 Genomic DNA. Translation: ADI66837.1.
RefSeqiWP_004011513.1. NC_014246.1.

Genome annotation databases

EnsemblBacteriaiADI66837; ADI66837; HMPREF0573_10518.
KEGGimcu:HMPREF0573_10518.
PATRICi38203082. VBIMobCur30313_0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001992 Genomic DNA. Translation: ADI66837.1.
RefSeqiWP_004011513.1. NC_014246.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI66837; ADI66837; HMPREF0573_10518.
KEGGimcu:HMPREF0573_10518.
PATRICi38203082. VBIMobCur30313_0504.

Phylogenomic databases

HOGENOMiHOG000229528.
KOiK03648.
OMAiLKPMLGD.
OrthoDBiPOG091H03VL.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6ZJD8_MOBCV
AccessioniPrimary (citable) accession number: D6ZJD8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.