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Protein

Alanine racemase

Gene

alr

Organism
Mobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei173 – 1731SubstrateUniRule annotation
Active sitei310 – 3101Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei358 – 3581Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMCUR548479:GH17-297-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HMPREF0573_10288Imported
OrganismiMobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)Imported
Taxonomic identifieri548479 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesActinomycineaeActinomycetaceaeMobiluncus/Falcivibrio groupMobiluncus
ProteomesiUP000006742 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6ZIQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 2 hits.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 2 hits.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6ZIQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVDVSQWP VRAVVNLSAY QENLAQMRRF APHSQQMAIV KANAYGHGIE
60 70 80 90 100
RMALAALGAG TEWLGVAKAS EAFRLRKYLD KHGVPRDHLV DTPTSAMMRS
110 120 130 140 150
RLYQTAAMGL PSATRPRILT WLYVPHTDLL PVVKSEIDIS VSTLDQLDQV
160 170 180 190 200
SRACDAAGKR ARLHLKVDTG LCRAGATDED FPVLCKLARA RERAGLVEVS
210 220 230 240 250
AVWSHLARAD EDTAAAEAFT KSQLKAFDEA WEVAQEAGLR PQLRHIAATA
260 270 280 290 300
GIIWYPESHY DLVRVGISGY GLSPNPEIAS SWQLGVRPVM RLETNVVQVK
310 320 330 340 350
RVEKGAAVSY GGEWVAPGPR WLGLLPVGYA DGLHRLAKNR GETWIKGRRA
360 370 380 390 400
PIVGRIPMDQ IVVDLGPAVD DTGTSVPCPV EPGELAIIFG DPKDRLLGGI
410 420 430 440
PGVPALPTAD DWAEWTDTIN YEVITSISPN VPRVYVKDEP ER
Length:442
Mass (Da):48,376
Last modified:August 10, 2010 - v1
Checksum:iBFE7807CEF3DC5AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001992 Genomic DNA. Translation: ADI66607.1.
RefSeqiYP_003718101.1. NC_014246.1.

Genome annotation databases

EnsemblBacteriaiADI66607; ADI66607; HMPREF0573_10288.
KEGGimcu:HMPREF0573_10288.
PATRICi38202608. VBIMobCur30313_0278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001992 Genomic DNA. Translation: ADI66607.1.
RefSeqiYP_003718101.1. NC_014246.1.

3D structure databases

ProteinModelPortaliD6ZIQ8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI66607; ADI66607; HMPREF0573_10288.
KEGGimcu:HMPREF0573_10288.
PATRICi38202608. VBIMobCur30313_0278.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiRTEEWIA.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMCUR548479:GH17-297-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 2 hits.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 2 hits.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Mobiluncus curtisii ATCC 43063."
    Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
    , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43063 / DSM 2711 / V125Imported.

Entry informationi

Entry nameiD6ZIQ8_MOBCV
AccessioniPrimary (citable) accession number: D6ZIQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 1, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.