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D6ZIQ8

- D6ZIQ8_MOBCV

UniProt

D6ZIQ8 - D6ZIQ8_MOBCV

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Protein

Alanine racemase

Gene
alr, HMPREF0573_10288
Organism
Mobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei41 – 411Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei173 – 1731Substrate By similarityUniRule annotation
Active sitei310 – 3101Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei358 – 3581Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMCUR548479:GH17-297-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:HMPREF0573_10288Imported
OrganismiMobiluncus curtisii (strain ATCC 43063 / DSM 2711 / V125) (Falcivibrio vaginalis)Imported
Taxonomic identifieri548479 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesActinomycineaeActinomycetaceaeMobiluncus/Falcivibrio groupMobiluncus
ProteomesiUP000006742: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6ZIQ8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiIAINAVE.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 2 hits.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 2 hits.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6ZIQ8-1 [UniParc]FASTAAdd to Basket

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MTNVDVSQWP VRAVVNLSAY QENLAQMRRF APHSQQMAIV KANAYGHGIE    50
RMALAALGAG TEWLGVAKAS EAFRLRKYLD KHGVPRDHLV DTPTSAMMRS 100
RLYQTAAMGL PSATRPRILT WLYVPHTDLL PVVKSEIDIS VSTLDQLDQV 150
SRACDAAGKR ARLHLKVDTG LCRAGATDED FPVLCKLARA RERAGLVEVS 200
AVWSHLARAD EDTAAAEAFT KSQLKAFDEA WEVAQEAGLR PQLRHIAATA 250
GIIWYPESHY DLVRVGISGY GLSPNPEIAS SWQLGVRPVM RLETNVVQVK 300
RVEKGAAVSY GGEWVAPGPR WLGLLPVGYA DGLHRLAKNR GETWIKGRRA 350
PIVGRIPMDQ IVVDLGPAVD DTGTSVPCPV EPGELAIIFG DPKDRLLGGI 400
PGVPALPTAD DWAEWTDTIN YEVITSISPN VPRVYVKDEP ER 442
Length:442
Mass (Da):48,376
Last modified:August 10, 2010 - v1
Checksum:iBFE7807CEF3DC5AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001992 Genomic DNA. Translation: ADI66607.1.
RefSeqiWP_013188702.1. NC_014246.1.
YP_003718101.1. NC_014246.1.

Genome annotation databases

EnsemblBacteriaiADI66607; ADI66607; HMPREF0573_10288.
GeneIDi9335927.
KEGGimcu:HMPREF0573_10288.
PATRICi38202608. VBIMobCur30313_0278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001992 Genomic DNA. Translation: ADI66607.1 .
RefSeqi WP_013188702.1. NC_014246.1.
YP_003718101.1. NC_014246.1.

3D structure databases

ProteinModelPortali D6ZIQ8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI66607 ; ADI66607 ; HMPREF0573_10288 .
GeneIDi 9335927.
KEGGi mcu:HMPREF0573_10288.
PATRICi 38202608. VBIMobCur30313_0278.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi IAINAVE.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MCUR548479:GH17-297-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 2 hits.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 2 hits.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Mobiluncus curtisii ATCC 43063."
    Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
    , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R., Gibbs R.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43063 / DSM 2711 / V125.

Entry informationi

Entry nameiD6ZIQ8_MOBCV
AccessioniPrimary (citable) accession number: D6ZIQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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