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Protein

Alanine racemase

Gene

Srot_0353

Organism
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei274 – 2741Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei322 – 3221Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSROT640132:GHEU-362-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Srot_0353Imported
OrganismiSegniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)Imported
Taxonomic identifieri640132 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeSegniliparaceaeSegniliparus
ProteomesiUP000002247 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6ZB81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6ZB81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAVQATVD HHAIAHNVRL LAQASAPAQV IAVLKANAYG HGAVPVARTA
60 70 80 90 100
LAAGAAQIGV ATLAEAFELR QGGIEAPIIA WLHAFDPDEA VAVFAEAIAS
110 120 130 140 150
GIELGVSTSS QVRAVAEAAL RADQLAVVAV KVDTGLNRGG FARGEWRKAF
160 170 180 190 200
ADLANAEAAG AVQVRGVFSH LANADRPEYR TNAEQARSLR EAVSFARAAG
210 220 230 240 250
LAPELVHLAN SPAVLTRPKA LVNELPVFNA TRPGVAVYGL SPIMGRDFGL
260 270 280 290 300
IPAMTLTARV GLTKRIHAGD GVSYGHDFVA ASDTTLALLP IGYADGLQRA
310 320 330 340 350
LAGKFEVSIG GRRYPGVGRV CMDQVLVDLG PGEPKVREGD TAVLFGPGSD
360 370 380 390
GEQTADDWAR AAGTINYEIV TQLRGRVQLR HIHQREPVDQ LRHTHHA
Length:397
Mass (Da):41,666
Last modified:August 10, 2010 - v1
Checksum:i98853E8F192AE9DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG96840.1.
RefSeqiWP_013137296.1. NC_014168.1.
YP_003657671.1. NC_014168.1.

Genome annotation databases

EnsemblBacteriaiADG96840; ADG96840; Srot_0353.
KEGGisrt:Srot_0353.
PATRICi38246887. VBISegRot51051_0354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG96840.1.
RefSeqiWP_013137296.1. NC_014168.1.
YP_003657671.1. NC_014168.1.

3D structure databases

ProteinModelPortaliD6ZB81.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG96840; ADG96840; Srot_0353.
KEGGisrt:Srot_0353.
PATRICi38246887. VBISegRot51051_0354.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciSROT640132:GHEU-362-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578Imported.

Entry informationi

Entry nameiD6ZB81_SEGRD
AccessioniPrimary (citable) accession number: D6ZB81
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 29, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.