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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei431D-inositol 3-phosphateUniRule annotation1
Binding sitei57UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei1121D-inositol 3-phosphateUniRule annotation1
Binding sitei1451D-inositol 3-phosphateUniRule annotation1
Binding sitei1691D-inositol 3-phosphateUniRule annotation1
Binding sitei1891D-inositol 3-phosphateUniRule annotation1
Binding sitei263UDP-GlcNAcUniRule annotation1
Binding sitei268UDP-GlcNAcUniRule annotation1
Binding sitei324UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi333Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi334Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi336Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei346UDP-GlcNAcUniRule annotation1
Binding sitei354UDP-GlcNAcUniRule annotation1
Metal bindingi360MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Srot_2070
OrganismiSegniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
Taxonomic identifieri640132 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesSegniliparaceaeSegniliparus
Proteomesi
  • UP000002247 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001581 – 449D-inositol 3-phosphate glycosyltransferaseAdd BLAST449

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi640132.Srot_2070.

Structurei

3D structure databases

ProteinModelPortaliD6Z995.
SMRiD6Z995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 50UDP-GlcNAc bindingUniRule annotation2
Regioni54 – 591D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

D6Z995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYPGGMAIP CQDTAAAPRP AAVSALPARS SPYLRRVAVL SLHTSPWAQP
60 70 80 90 100
GTGDAGGMNV YIRNTSTVLA RRGVAVEIFT RATSSDDPPS WEPVPGVTLH
110 120 130 140 150
NVVAGPFEGL RKEELPSQLC AFTAGVLREC VGHEAWRHSL VHSHYWLSGQ
160 170 180 190 200
VGWLIKDRLG VPLVHTAHTL AAVKNVTLAE GDVPEPLQRL VGEGQLVAES
210 220 230 240 250
DRMVANTQVE AGHLTQYYAA DPQKIDVVPP GVDLGMFRPG DKAAARAELG
260 270 280 290 300
LDPSEQVVAF VGRIQPLKGP DILLAAMAEV MRAKPGVRLL VVGEASGSGL
310 320 330 340 350
SPEGIMATAE RLGVADNVTM WPAQPPAQLA KVYRAADLVA VPSHSESFGL
360 370 380 390 400
VAIEAQACGT PVVAAKVGGL PVAVADQVSG VLVDSWAPER WQAEIASLLA
410 420 430 440
APERLRAMGR AGVAHAGRFS WEATADGLLA SYRAALRGGA LAPMRAVRG
Length:449
Mass (Da):47,075
Last modified:August 10, 2010 - v1
Checksum:iD3D908B5C9D3E4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG98525.1.

Genome annotation databases

EnsemblBacteriaiADG98525; ADG98525; Srot_2070.
KEGGisrt:Srot_2070.
PATRICi38250456. VBISegRot51051_2111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG98525.1.

3D structure databases

ProteinModelPortaliD6Z995.
SMRiD6Z995.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi640132.Srot_2070.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG98525; ADG98525; Srot_2070.
KEGGisrt:Srot_2070.
PATRICi38250456. VBISegRot51051_2111.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_SEGRD
AccessioniPrimary (citable) accession number: D6Z995
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.