Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

D6Z8R6 (D6Z8R6_SEGRD) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding310 – 3156NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
D6Z8R6 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 50C8180F462AE581

FASTA40544,894
        10         20         30         40         50         60 
MSKIKVEGVV VELDGDEMTR IIWKFIKDKL IHPYLDIELD YYDLGIENRD ATDDRVTVEA 

        70         80         90        100        110        120 
AEAIKRHGVG VKCATITPDE ARVVEFGLKK MWRSPNGTIR NILGGTIFRA PIIIASVPRL 

       130        140        150        160        170        180 
VPGWTKPIII GRHAFGDQYR ATDFKASGAG TVTITYTPAD GGEPIQHEVV KLPQEGGVVM 

       190        200        210        220        230        240 
GMYNFNESIR DFARASLNYG LQQNYPVYLS TKNTILKAYD GAFKDIFQEV YEQEFKAEFD 

       250        260        270        280        290        300 
AAGLTYEHRL IDDMVASALK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG 

       310        320        330        340        350        360 
KICESEAAHG TVTRHYRQYQ QGKPTSTNPV ASIFAWTRGI AHRGRLDGSR AVEAFAHKLE 

       370        380        390        400 
DVVVRTIEDG KMTKDLALLV GDGQGWLTTE EFLAALDENL QAELA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001958 Genomic DNA. Translation: ADG98346.1.
RefSeqYP_003659177.1. NC_014168.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG98346; ADG98346; Srot_1886.
GeneID9179947.
KEGGsrt:Srot_1886.
PATRIC38250068. VBISegRot51051_1920.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.

Enzyme and pathway databases

BioCycSROT640132:GHEU-1922-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6Z8R6_SEGRD
AccessionPrimary (citable) accession number: D6Z8R6
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)