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D6Z8R6

- D6Z8R6_SEGRD

UniProt

D6Z8R6 - D6Z8R6_SEGRD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Srot_1886

Organism
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganese
    Binding sitei260 – 2601NADPUniRule annotation
    Metal bindingi275 – 2751Magnesium or manganese
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi310 – 3156NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSROT640132:GHEU-1922-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Srot_1886Imported
    OrganismiSegniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)Imported
    Taxonomic identifieri640132 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeSegniliparaceaeSegniliparus
    ProteomesiUP000002247: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6Z8R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKIKVEGVV VELDGDEMTR IIWKFIKDKL IHPYLDIELD YYDLGIENRD    50
    ATDDRVTVEA AEAIKRHGVG VKCATITPDE ARVVEFGLKK MWRSPNGTIR 100
    NILGGTIFRA PIIIASVPRL VPGWTKPIII GRHAFGDQYR ATDFKASGAG 150
    TVTITYTPAD GGEPIQHEVV KLPQEGGVVM GMYNFNESIR DFARASLNYG 200
    LQQNYPVYLS TKNTILKAYD GAFKDIFQEV YEQEFKAEFD AAGLTYEHRL 250
    IDDMVASALK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG 300
    KICESEAAHG TVTRHYRQYQ QGKPTSTNPV ASIFAWTRGI AHRGRLDGSR 350
    AVEAFAHKLE DVVVRTIEDG KMTKDLALLV GDGQGWLTTE EFLAALDENL 400
    QAELA 405
    Length:405
    Mass (Da):44,894
    Last modified:August 10, 2010 - v1
    Checksum:i50C8180F462AE581
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001958 Genomic DNA. Translation: ADG98346.1.
    RefSeqiWP_013138799.1. NC_014168.1.
    YP_003659177.1. NC_014168.1.

    Genome annotation databases

    EnsemblBacteriaiADG98346; ADG98346; Srot_1886.
    GeneIDi9179947.
    KEGGisrt:Srot_1886.
    PATRICi38250068. VBISegRot51051_1920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001958 Genomic DNA. Translation: ADG98346.1 .
    RefSeqi WP_013138799.1. NC_014168.1.
    YP_003659177.1. NC_014168.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG98346 ; ADG98346 ; Srot_1886 .
    GeneIDi 9179947.
    KEGGi srt:Srot_1886.
    PATRICi 38250068. VBISegRot51051_1920.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci SROT640132:GHEU-1922-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578Imported.

    Entry informationi

    Entry nameiD6Z8R6_SEGRD
    AccessioniPrimary (citable) accession number: D6Z8R6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3