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D6Z8R6

- D6Z8R6_SEGRD

UniProt

D6Z8R6 - D6Z8R6_SEGRD

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Srot_1886

Organism
Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei212 – 2121Critical for catalysisUniRule annotation
Binding sitei260 – 2601NADPUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi310 – 3156NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSROT640132:GHEU-1922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Srot_1886Imported
OrganismiSegniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578)Imported
Taxonomic identifieri640132 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeSegniliparaceaeSegniliparus
ProteomesiUP000002247: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6Z8R6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKIKVEGVV VELDGDEMTR IIWKFIKDKL IHPYLDIELD YYDLGIENRD
60 70 80 90 100
ATDDRVTVEA AEAIKRHGVG VKCATITPDE ARVVEFGLKK MWRSPNGTIR
110 120 130 140 150
NILGGTIFRA PIIIASVPRL VPGWTKPIII GRHAFGDQYR ATDFKASGAG
160 170 180 190 200
TVTITYTPAD GGEPIQHEVV KLPQEGGVVM GMYNFNESIR DFARASLNYG
210 220 230 240 250
LQQNYPVYLS TKNTILKAYD GAFKDIFQEV YEQEFKAEFD AAGLTYEHRL
260 270 280 290 300
IDDMVASALK WEGGYVWACK NYDGDVQSDT VAQGFGSLGL MTSVLLTPDG
310 320 330 340 350
KICESEAAHG TVTRHYRQYQ QGKPTSTNPV ASIFAWTRGI AHRGRLDGSR
360 370 380 390 400
AVEAFAHKLE DVVVRTIEDG KMTKDLALLV GDGQGWLTTE EFLAALDENL

QAELA
Length:405
Mass (Da):44,894
Last modified:August 10, 2010 - v1
Checksum:i50C8180F462AE581
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG98346.1.
RefSeqiWP_013138799.1. NC_014168.1.
YP_003659177.1. NC_014168.1.

Genome annotation databases

EnsemblBacteriaiADG98346; ADG98346; Srot_1886.
GeneIDi9179947.
KEGGisrt:Srot_1886.
PATRICi38250068. VBISegRot51051_1920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001958 Genomic DNA. Translation: ADG98346.1 .
RefSeqi WP_013138799.1. NC_014168.1.
YP_003659177.1. NC_014168.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG98346 ; ADG98346 ; Srot_1886 .
GeneIDi 9179947.
KEGGi srt:Srot_1886.
PATRICi 38250068. VBISegRot51051_1920.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci SROT640132:GHEU-1922-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578Imported.

Entry informationi

Entry nameiD6Z8R6_SEGRD
AccessioniPrimary (citable) accession number: D6Z8R6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3