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D6YWZ1

- D6YWZ1_WADCW

UniProt

D6YWZ1 - D6YWZ1_WADCW

Protein

D-alanine--D-alanine ligase

Gene

ddlA3

Organism
Waddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi314 – 3141Magnesium or manganese 1UniRule annotation
    Metal bindingi328 – 3281Magnesium or manganese 1UniRule annotation
    Metal bindingi328 – 3281Magnesium or manganese 2UniRule annotation
    Metal bindingi330 – 3301Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi173 – 22856ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciWCHO716544:GHGA-1300-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlA3Imported
    Synonyms:ddlUniRule annotation
    Ordered Locus Names:wcw_1300Imported
    OrganismiWaddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)Imported
    Taxonomic identifieri716544 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesWaddliaceaeWaddlia
    ProteomesiUP000001505: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD6YWZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 358219ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000011593.
    KOiK01921.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6YWZ1-1 [UniParc]FASTAAdd to Basket

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    MLDLAVLFGG RSIEHEISVI TGLQAILALN PKKYKILPVY FALNGKWYTG    50
    DPLLERSFYR KLPAAYSDLT EITLLPDPSI GGFKDLALNR TYPVDRCLLC 100
    FHGQYGEDGC VQGLLELAGL PYTGSRVLSS ALTMSKSHTK LLLQALNIPC 150
    LPHVVVDKQE AVSDLAAVRK KILDTLRYPL FIKPNHLGSS IGIAKATDKN 200
    SLDRALAKVF LYDSAAIIEP YLDNLLEINV SVLEGDPPRS SAVEIPIASQ 250
    EALSYEDKYL KGGAKSTGGS SQGMAGLTRM IDPQDLDLKI KQGVINHALK 300
    AFKELSCSGV CRFDFMLDTS TETLYFNEAN PIPGSLSFYL WDRTEPKLLY 350
    SELLDVLIER CAHKSALQRS LKKDFGFQAL 380
    Length:380
    Mass (Da):41,894
    Last modified:August 10, 2010 - v1
    Checksum:i13FDB2A51BDE3149
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001928 Genomic DNA. Translation: ADI38652.1.
    RefSeqiWP_013182363.1. NC_014225.1.
    YP_003709658.1. NC_014225.1.

    Genome annotation databases

    EnsemblBacteriaiADI38652; ADI38652; wcw_1300.
    GeneIDi9278279.
    KEGGiwch:wcw_1300.
    PATRICi38314594. VBIWadCho156037_1262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001928 Genomic DNA. Translation: ADI38652.1 .
    RefSeqi WP_013182363.1. NC_014225.1.
    YP_003709658.1. NC_014225.1.

    3D structure databases

    ProteinModelPortali D6YWZ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI38652 ; ADI38652 ; wcw_1300 .
    GeneIDi 9278279.
    KEGGi wch:wcw_1300.
    PATRICi 38314594. VBIWadCho156037_1262.

    Phylogenomic databases

    HOGENOMi HOG000011593.
    KOi K01921.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci WCHO716544:GHGA-1300-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1470 / WSU 86-1044Imported.

    Entry informationi

    Entry nameiD6YWZ1_WADCW
    AccessioniPrimary (citable) accession number: D6YWZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3