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D6YWZ1

- D6YWZ1_WADCW

UniProt

D6YWZ1 - D6YWZ1_WADCW

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Protein
D-alanine--D-alanine ligase
Gene
ddlA3, ddl, wcw_1300
Organism
Waddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi314 – 3141Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi328 – 3281Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi328 – 3281Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi330 – 3301Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi173 – 22856ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciWCHO716544:GHGA-1300-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlA3Imported
Synonyms:ddlUniRule annotation
Ordered Locus Names:wcw_1300Imported
OrganismiWaddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)Imported
Taxonomic identifieri716544 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesWaddliaceaeWaddlia
ProteomesiUP000001505: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD6YWZ1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 358219ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6YWZ1-1 [UniParc]FASTAAdd to Basket

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MLDLAVLFGG RSIEHEISVI TGLQAILALN PKKYKILPVY FALNGKWYTG    50
DPLLERSFYR KLPAAYSDLT EITLLPDPSI GGFKDLALNR TYPVDRCLLC 100
FHGQYGEDGC VQGLLELAGL PYTGSRVLSS ALTMSKSHTK LLLQALNIPC 150
LPHVVVDKQE AVSDLAAVRK KILDTLRYPL FIKPNHLGSS IGIAKATDKN 200
SLDRALAKVF LYDSAAIIEP YLDNLLEINV SVLEGDPPRS SAVEIPIASQ 250
EALSYEDKYL KGGAKSTGGS SQGMAGLTRM IDPQDLDLKI KQGVINHALK 300
AFKELSCSGV CRFDFMLDTS TETLYFNEAN PIPGSLSFYL WDRTEPKLLY 350
SELLDVLIER CAHKSALQRS LKKDFGFQAL 380
Length:380
Mass (Da):41,894
Last modified:August 10, 2010 - v1
Checksum:i13FDB2A51BDE3149
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001928 Genomic DNA. Translation: ADI38652.1.
RefSeqiWP_013182363.1. NC_014225.1.
YP_003709658.1. NC_014225.1.

Genome annotation databases

EnsemblBacteriaiADI38652; ADI38652; wcw_1300.
GeneIDi9278279.
KEGGiwch:wcw_1300.
PATRICi38314594. VBIWadCho156037_1262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001928 Genomic DNA. Translation: ADI38652.1 .
RefSeqi WP_013182363.1. NC_014225.1.
YP_003709658.1. NC_014225.1.

3D structure databases

ProteinModelPortali D6YWZ1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADI38652 ; ADI38652 ; wcw_1300 .
GeneIDi 9278279.
KEGGi wch:wcw_1300.
PATRICi 38314594. VBIWadCho156037_1262.

Phylogenomic databases

HOGENOMi HOG000011593.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci WCHO716544:GHGA-1300-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1470 / WSU 86-1044.

Entry informationi

Entry nameiD6YWZ1_WADCW
AccessioniPrimary (citable) accession number: D6YWZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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