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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Waddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotationImported
Ordered Locus Names:wcw_1484Imported
OrganismiWaddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)Imported
Taxonomic identifieri716544 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesWaddliaceaeWaddlia
Proteomesi
  • UP000001505 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei326 – 346HelicalUniRule annotationAdd BLAST21
Transmembranei386 – 406HelicalUniRule annotationAdd BLAST21
Transmembranei412 – 432HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi716544.wcw_1484.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6YRY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQALQRVFS IPELRQKISF TLLMLVVCRI GAFIPVPGIN GEVAIQYLRH
60 70 80 90 100
LTGGEQNLFR MVDTFTGGAF SQMTVIALGV VPYISASIMM QLFTALIPSL
110 120 130 140 150
QREIQENPTL GRRKVNRLTR LVTLILAFIQ SAMFAKYAIQ MNITKPGIIA
160 170 180 190 200
GDLLNIQMFG HPVLFYAVMI FTMTTGTLFL MWIGEQITEN GIGNGMSLII
210 220 230 240 250
TLGIISSFPT AIGMIFQQLN LDSQEAGQLN FAIVAVIMAV FVLVTIGTIL
260 270 280 290 300
IVQGHRRIPL QYARRVVGRK EVQGGNSYIP LKVNYAGVIP VIFASSLLMF
310 320 330 340 350
PATIATFIGQ GTWLESVAMW FRQDRTAYMV MYVGLIIFFT YFWTATQFRP
360 370 380 390 400
DQIASDMKKN GAFIPGIRQG RPTQEYLEHT MNRITLIGAV FLALIAILPT
410 420 430 440 450
ITGRVLGVSQ TISYFFGGTA LLILVGVVLD TMKQIESHLL MKRYEGFMKK

GRARGR
Length:456
Mass (Da):50,748
Last modified:August 10, 2010 - v1
Checksum:i85C3FF5BEC463541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001928 Genomic DNA. Translation: ADI38833.1.
RefSeqiWP_013182541.1. NZ_LVEB01000002.1.

Genome annotation databases

EnsemblBacteriaiADI38833; ADI38833; wcw_1484.
KEGGiwch:wcw_1484.
PATRICi38314956. VBIWadCho156037_1440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001928 Genomic DNA. Translation: ADI38833.1.
RefSeqiWP_013182541.1. NZ_LVEB01000002.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi716544.wcw_1484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADI38833; ADI38833; wcw_1484.
KEGGiwch:wcw_1484.
PATRICi38314956. VBIWadCho156037_1440.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080586.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6YRY8_WADCW
AccessioniPrimary (citable) accession number: D6YRY8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: November 2, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.