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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Waddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport

Enzyme and pathway databases

BioCyciWCHO716544:G1GLF-1444-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotationImported
Ordered Locus Names:wcw_1484Imported
OrganismiWaddlia chondrophila (strain ATCC VR-1470 / WSU 86-1044)Imported
Taxonomic identifieri716544 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeParachlamydialesWaddliaceaeWaddlia
Proteomesi
  • UP000001505 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 39HelicalUniRule annotationAdd BLAST20
Transmembranei75 – 97HelicalUniRule annotationAdd BLAST23
Transmembranei118 – 139HelicalUniRule annotationAdd BLAST22
Transmembranei159 – 183HelicalUniRule annotationAdd BLAST25
Transmembranei195 – 217HelicalUniRule annotationAdd BLAST23
Transmembranei229 – 252HelicalUniRule annotationAdd BLAST24
Transmembranei285 – 308HelicalUniRule annotationAdd BLAST24
Transmembranei328 – 348HelicalUniRule annotationAdd BLAST21
Transmembranei384 – 406HelicalUniRule annotationAdd BLAST23
Transmembranei412 – 432HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi716544.wcw_1484

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGG Bacteria
COG0201 LUCA
HOGENOMiHOG000080586
KOiK03076
OMAiQTYVISQ
OrthoDBiPOG091H024M

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

D6YRY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQALQRVFS IPELRQKISF TLLMLVVCRI GAFIPVPGIN GEVAIQYLRH
60 70 80 90 100
LTGGEQNLFR MVDTFTGGAF SQMTVIALGV VPYISASIMM QLFTALIPSL
110 120 130 140 150
QREIQENPTL GRRKVNRLTR LVTLILAFIQ SAMFAKYAIQ MNITKPGIIA
160 170 180 190 200
GDLLNIQMFG HPVLFYAVMI FTMTTGTLFL MWIGEQITEN GIGNGMSLII
210 220 230 240 250
TLGIISSFPT AIGMIFQQLN LDSQEAGQLN FAIVAVIMAV FVLVTIGTIL
260 270 280 290 300
IVQGHRRIPL QYARRVVGRK EVQGGNSYIP LKVNYAGVIP VIFASSLLMF
310 320 330 340 350
PATIATFIGQ GTWLESVAMW FRQDRTAYMV MYVGLIIFFT YFWTATQFRP
360 370 380 390 400
DQIASDMKKN GAFIPGIRQG RPTQEYLEHT MNRITLIGAV FLALIAILPT
410 420 430 440 450
ITGRVLGVSQ TISYFFGGTA LLILVGVVLD TMKQIESHLL MKRYEGFMKK

GRARGR
Length:456
Mass (Da):50,748
Last modified:August 10, 2010 - v1
Checksum:i85C3FF5BEC463541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001928 Genomic DNA Translation: ADI38833.1
RefSeqiWP_013182541.1, NZ_LVEB01000002.1

Genome annotation databases

EnsemblBacteriaiADI38833; ADI38833; wcw_1484
KEGGiwch:wcw_1484

Similar proteinsi

Entry informationi

Entry nameiD6YRY8_WADCW
AccessioniPrimary (citable) accession number: D6YRY8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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