Ribonuclease 3 - Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)

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D6Y663 (D6Y663_THEBD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Ribonuclease 3 HAMAP-Rule MF_00104
EC=3.1.26.3 HAMAP-Rule MF_00104

Alternative name(s):
Ribonuclease III HAMAP-Rule MF_00104

Gene names

Name:	rnc HAMAP-Rule MF_00104
Ordered Locus Names:	Tbis_2780 EMBL ADG89479.1

Organism

Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51) [Complete proteome] [HAMAP] EMBL ADG89479.1

Taxonomic identifier

469371 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Pseudonocardiaceae › Thermobispora ›

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104 SAAS SAAS011907
Cofactor	Mg²⁺ By similarity. HAMAP-Rule MF_00104 SAAS SAAS000999
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00104 SAAS SAAS011907
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00104 SAAS SAAS011907.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. HAMAP-Rule MF_00104 SAAS SAAS011907 Contains 1 RNase III domain. HAMAP-Rule MF_00104 SAAS SAAS011907

Ontologies

Keywords
Biological process	mRNA processing HAMAP-Rule MF_00104 SAAS SAAS011907 rRNA processing HAMAP-Rule MF_00104 SAAS SAAS011907 tRNA processing HAMAP-Rule MF_00104 SAAS SAAS011907
Cellular component	Cytoplasm HAMAP-Rule MF_00104 SAAS SAAS011907
Ligand	Magnesium HAMAP-Rule MF_00104 SAAS SAAS011907 Metal-binding HAMAP-Rule MF_00104 SAAS SAAS011907 RNA-binding rRNA-binding HAMAP-Rule MF_00104 SAAS SAAS000999
Molecular function	Endonuclease HAMAP-Rule MF_00104 SAAS SAAS011907 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA catabolic process Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: HAMAP tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease III activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Domain

11 – 141

131

RNase III By similarity HAMAP-Rule MF_00104

Domain

168 – 236

DRBM By similarity HAMAP-Rule MF_00104

Sites

Active site

By similarity HAMAP-Rule MF_00104

Active site

130

By similarity HAMAP-Rule MF_00104

Metal binding

Magnesium By similarity HAMAP-Rule MF_00104

Metal binding

127

Magnesium By similarity HAMAP-Rule MF_00104

Metal binding

130

Magnesium By similarity HAMAP-Rule MF_00104

Sequences

Sequence

Length

Mass (Da)

Tools

D6Y663 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: E8AC3369627AAC9A
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FASTA

267

28,432

        10         20         30         40         50         60 
MAASGSKPVD VEIVRQELGE ILDVELSPDI LEQALTHRSY AYENGGLPTN ERLEFLGDSV 

        70         80         90        100        110        120 
LGLVVTDTLY RNHPDMPEGQ LAKLRAAVVN MRALADVARS LDLGKYLRLG RGEEGTGGRD 

       130        140        150        160        170        180 
KSSILADTLE ALIGTVYVDK GLDEAFRVVH QLFDPLIERS ASLGAGLDWK TSLQELTAAE 

       190        200        210        220        230        240 
SLGVPEYHVD ESGPDHAKSF VATVRVGGKE YGKGTGRSKK EAEQQAAEAA WTAIRAMRDA 

       250        260 
KEKAGKAEDG GAQRTGEPAG GAGTGES

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References

[1]

"The complete genome of Thermobispora bispora DSM 43833."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F.

Eisen J.A.
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001874 Genomic DNA. Translation: ADG89479.1.
RefSeq	YP_003653372.1. NC_014165.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADG89479; ADG89479; Tbis_2780.
GeneID	9169293.
KEGG	tbi:Tbis_2780.
PATRIC	38288745. VBITheBis80272_2895.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000246808.
KO	K03685.
Family and domain databases
Gene3D	1.10.1520.10. 1 hit. 3.30.160.20. 1 hit.
HAMAP	MF_00104. RNase_III.
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like_dom. IPR011907. RNase_III. IPR000999. RNase_III_dom. [Graphical view]
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D6Y663_THEBD

Accession

Primary (citable) accession number: D6Y663

Entry history

Integrated into UniProtKB/TrEMBL:	August 10, 2010
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information