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D6Y4G5

- D6Y4G5_THEBD

UniProt

D6Y4G5 - D6Y4G5_THEBD

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Protein

Probable DNA ligase

Gene

lig

Organism
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATPUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
Binding sitei216 – 2161ATPUniRule annotation
Binding sitei231 – 2311ATPUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei300 – 3001ATPUniRule annotation
Binding sitei372 – 3721ATPUniRule annotation
Binding sitei378 – 3781ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTBIS469371:GHSI-2473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotationImported
Ordered Locus Names:Tbis_2438Imported
OrganismiThermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)Imported
Taxonomic identifieri469371 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeThermobispora
ProteomesiUP000006640: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6Y4G5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLIELARTS AAVAADSSRK AKIGHLAELL RRAGPDEAEI AIAYLSGELP
60 70 80 90 100
QRQIGVGWRS LLDLPGPRQI ATATVTQVDA MLERIKAQSG PGSQAARREL
110 120 130 140 150
LGELFASLTE QEQSFLRRLL AGELRQGALE GVMIEAIAAA AEVPAQEVRR
160 170 180 190 200
ALTLRGSLPA VGAAALRGGV AALREFRLEV GRPVAPMLAQ SAPSVTAALE
210 220 230 240 250
KIGGPAAIEW KFDGVRVQAH RKGGWVGVFT RTLDDITAQV PELVEAVLAL
260 270 280 290 300
PDDDLVLDGE VIALRPDGRP EPFQVTSGRV ASRTDVAALR KSVPLSVFFF
310 320 330 340 350
DALRVGGADL LDLPGSERHA ALEAAVPAEL IAPRIVTGDP DEGERFFSDA
360 370 380 390 400
IQRGHEGVVV KSPQTPYTAG RRGAGWIKVK PRHTLDLVVL AAEWGSGRRT
410 420 430 440 450
GWLSNLHLGA YDPETGGFVM LGKTFKGLTD ELLAWQTERL LRLAVGPTDG
460 470 480 490 500
WVVTVKPELV VEIAFDGVQR SPRYPGGMAL RFARVLRYRP DKRPEQADTV

AAVRALLPR
Length:509
Mass (Da):54,683
Last modified:August 10, 2010 - v1
Checksum:i54C6451531537478
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001874 Genomic DNA. Translation: ADG89141.1.
RefSeqiWP_013132674.1. NC_014165.1.
YP_003653034.1. NC_014165.1.

Genome annotation databases

EnsemblBacteriaiADG89141; ADG89141; Tbis_2438.
GeneIDi9168942.
KEGGitbi:Tbis_2438.
PATRICi38288031. VBITheBis80272_2547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001874 Genomic DNA. Translation: ADG89141.1 .
RefSeqi WP_013132674.1. NC_014165.1.
YP_003653034.1. NC_014165.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADG89141 ; ADG89141 ; Tbis_2438 .
GeneIDi 9168942.
KEGGi tbi:Tbis_2438.
PATRICi 38288031. VBITheBis80272_2547.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci TBIS469371:GHSI-2473-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51Imported.

Entry informationi

Entry nameiD6Y4G5_THEBD
AccessioniPrimary (citable) accession number: D6Y4G5
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3