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Protein

Probable DNA ligase

Gene

lig

Organism
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei372ATPUniRule annotation1
Binding sitei378ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTBIS469371:G1GL8-2430-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotationImported
Ordered Locus Names:Tbis_2438Imported
OrganismiThermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)Imported
Taxonomic identifieri469371 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteria incertae sedisThermobispora
Proteomesi
  • UP000006640 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi469371.Tbis_2438

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 412DNA_LIGASE_A3InterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D6Y4G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIELARTS AAVAADSSRK AKIGHLAELL RRAGPDEAEI AIAYLSGELP
60 70 80 90 100
QRQIGVGWRS LLDLPGPRQI ATATVTQVDA MLERIKAQSG PGSQAARREL
110 120 130 140 150
LGELFASLTE QEQSFLRRLL AGELRQGALE GVMIEAIAAA AEVPAQEVRR
160 170 180 190 200
ALTLRGSLPA VGAAALRGGV AALREFRLEV GRPVAPMLAQ SAPSVTAALE
210 220 230 240 250
KIGGPAAIEW KFDGVRVQAH RKGGWVGVFT RTLDDITAQV PELVEAVLAL
260 270 280 290 300
PDDDLVLDGE VIALRPDGRP EPFQVTSGRV ASRTDVAALR KSVPLSVFFF
310 320 330 340 350
DALRVGGADL LDLPGSERHA ALEAAVPAEL IAPRIVTGDP DEGERFFSDA
360 370 380 390 400
IQRGHEGVVV KSPQTPYTAG RRGAGWIKVK PRHTLDLVVL AAEWGSGRRT
410 420 430 440 450
GWLSNLHLGA YDPETGGFVM LGKTFKGLTD ELLAWQTERL LRLAVGPTDG
460 470 480 490 500
WVVTVKPELV VEIAFDGVQR SPRYPGGMAL RFARVLRYRP DKRPEQADTV

AAVRALLPR
Length:509
Mass (Da):54,683
Last modified:August 10, 2010 - v1
Checksum:i54C6451531537478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001874 Genomic DNA Translation: ADG89141.1
RefSeqiWP_013132674.1, NC_014165.1

Genome annotation databases

EnsemblBacteriaiADG89141; ADG89141; Tbis_2438
KEGGitbi:Tbis_2438

Similar proteinsi

Entry informationi

Entry nameiD6Y4G5_THEBD
AccessioniPrimary (citable) accession number: D6Y4G5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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