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D6Y4G5 (D6Y4G5_THEBD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2111N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2091ATP By similarity HAMAP-Rule MF_00407
Binding site2161ATP By similarity HAMAP-Rule MF_00407
Binding site2311ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site3001ATP By similarity HAMAP-Rule MF_00407
Binding site3721ATP By similarity HAMAP-Rule MF_00407
Binding site3781ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D6Y4G5 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 54C6451531537478

FASTA50954,683
        10         20         30         40         50         60 
MLLIELARTS AAVAADSSRK AKIGHLAELL RRAGPDEAEI AIAYLSGELP QRQIGVGWRS 

        70         80         90        100        110        120 
LLDLPGPRQI ATATVTQVDA MLERIKAQSG PGSQAARREL LGELFASLTE QEQSFLRRLL 

       130        140        150        160        170        180 
AGELRQGALE GVMIEAIAAA AEVPAQEVRR ALTLRGSLPA VGAAALRGGV AALREFRLEV 

       190        200        210        220        230        240 
GRPVAPMLAQ SAPSVTAALE KIGGPAAIEW KFDGVRVQAH RKGGWVGVFT RTLDDITAQV 

       250        260        270        280        290        300 
PELVEAVLAL PDDDLVLDGE VIALRPDGRP EPFQVTSGRV ASRTDVAALR KSVPLSVFFF 

       310        320        330        340        350        360 
DALRVGGADL LDLPGSERHA ALEAAVPAEL IAPRIVTGDP DEGERFFSDA IQRGHEGVVV 

       370        380        390        400        410        420 
KSPQTPYTAG RRGAGWIKVK PRHTLDLVVL AAEWGSGRRT GWLSNLHLGA YDPETGGFVM 

       430        440        450        460        470        480 
LGKTFKGLTD ELLAWQTERL LRLAVGPTDG WVVTVKPELV VEIAFDGVQR SPRYPGGMAL 

       490        500 
RFARVLRYRP DKRPEQADTV AAVRALLPR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001874 Genomic DNA. Translation: ADG89141.1.
RefSeqYP_003653034.1. NC_014165.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADG89141; ADG89141; Tbis_2438.
GeneID9168942.
KEGGtbi:Tbis_2438.
PATRIC38288031. VBITheBis80272_2547.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK01971.
OMAGRPRPFQ.

Enzyme and pathway databases

BioCycTBIS469371:GHSI-2473-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6Y4G5_THEBD
AccessionPrimary (citable) accession number: D6Y4G5
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)