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D6Y4G5

- D6Y4G5_THEBD

UniProt

D6Y4G5 - D6Y4G5_THEBD

Protein

Probable DNA ligase

Gene

lig

Organism
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei209 – 2091ATPUniRule annotation
    Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
    Binding sitei216 – 2161ATPUniRule annotation
    Binding sitei231 – 2311ATPUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei372 – 3721ATPUniRule annotation
    Binding sitei378 – 3781ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTBIS469371:GHSI-2473-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotationImported
    Ordered Locus Names:Tbis_2438Imported
    OrganismiThermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)Imported
    Taxonomic identifieri469371 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPseudonocardineaePseudonocardiaceaeThermobispora
    ProteomesiUP000006640: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6Y4G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLIELARTS AAVAADSSRK AKIGHLAELL RRAGPDEAEI AIAYLSGELP    50
    QRQIGVGWRS LLDLPGPRQI ATATVTQVDA MLERIKAQSG PGSQAARREL 100
    LGELFASLTE QEQSFLRRLL AGELRQGALE GVMIEAIAAA AEVPAQEVRR 150
    ALTLRGSLPA VGAAALRGGV AALREFRLEV GRPVAPMLAQ SAPSVTAALE 200
    KIGGPAAIEW KFDGVRVQAH RKGGWVGVFT RTLDDITAQV PELVEAVLAL 250
    PDDDLVLDGE VIALRPDGRP EPFQVTSGRV ASRTDVAALR KSVPLSVFFF 300
    DALRVGGADL LDLPGSERHA ALEAAVPAEL IAPRIVTGDP DEGERFFSDA 350
    IQRGHEGVVV KSPQTPYTAG RRGAGWIKVK PRHTLDLVVL AAEWGSGRRT 400
    GWLSNLHLGA YDPETGGFVM LGKTFKGLTD ELLAWQTERL LRLAVGPTDG 450
    WVVTVKPELV VEIAFDGVQR SPRYPGGMAL RFARVLRYRP DKRPEQADTV 500
    AAVRALLPR 509
    Length:509
    Mass (Da):54,683
    Last modified:August 10, 2010 - v1
    Checksum:i54C6451531537478
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001874 Genomic DNA. Translation: ADG89141.1.
    RefSeqiWP_013132674.1. NC_014165.1.
    YP_003653034.1. NC_014165.1.

    Genome annotation databases

    EnsemblBacteriaiADG89141; ADG89141; Tbis_2438.
    GeneIDi9168942.
    KEGGitbi:Tbis_2438.
    PATRICi38288031. VBITheBis80272_2547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001874 Genomic DNA. Translation: ADG89141.1 .
    RefSeqi WP_013132674.1. NC_014165.1.
    YP_003653034.1. NC_014165.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADG89141 ; ADG89141 ; Tbis_2438 .
    GeneIDi 9168942.
    KEGGi tbi:Tbis_2438.
    PATRICi 38288031. VBITheBis80272_2547.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci TBIS469371:GHSI-2473-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51Imported.

    Entry informationi

    Entry nameiD6Y4G5_THEBD
    AccessioniPrimary (citable) accession number: D6Y4G5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3