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Protein

Probable DNA ligase

Gene

lig

Organism
Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATPUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
Binding sitei216 – 2161ATPUniRule annotation
Binding sitei231 – 2311ATPUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei300 – 3001ATPUniRule annotation
Binding sitei372 – 3721ATPUniRule annotation
Binding sitei378 – 3781ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTBIS469371:GHSI-2473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotationImported
Ordered Locus Names:Tbis_2438Imported
OrganismiThermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)Imported
Taxonomic identifieri469371 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteria incertae sedisThermobispora
ProteomesiUP000006640 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi469371.Tbis_2438.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6Y4G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIELARTS AAVAADSSRK AKIGHLAELL RRAGPDEAEI AIAYLSGELP
60 70 80 90 100
QRQIGVGWRS LLDLPGPRQI ATATVTQVDA MLERIKAQSG PGSQAARREL
110 120 130 140 150
LGELFASLTE QEQSFLRRLL AGELRQGALE GVMIEAIAAA AEVPAQEVRR
160 170 180 190 200
ALTLRGSLPA VGAAALRGGV AALREFRLEV GRPVAPMLAQ SAPSVTAALE
210 220 230 240 250
KIGGPAAIEW KFDGVRVQAH RKGGWVGVFT RTLDDITAQV PELVEAVLAL
260 270 280 290 300
PDDDLVLDGE VIALRPDGRP EPFQVTSGRV ASRTDVAALR KSVPLSVFFF
310 320 330 340 350
DALRVGGADL LDLPGSERHA ALEAAVPAEL IAPRIVTGDP DEGERFFSDA
360 370 380 390 400
IQRGHEGVVV KSPQTPYTAG RRGAGWIKVK PRHTLDLVVL AAEWGSGRRT
410 420 430 440 450
GWLSNLHLGA YDPETGGFVM LGKTFKGLTD ELLAWQTERL LRLAVGPTDG
460 470 480 490 500
WVVTVKPELV VEIAFDGVQR SPRYPGGMAL RFARVLRYRP DKRPEQADTV

AAVRALLPR
Length:509
Mass (Da):54,683
Last modified:August 10, 2010 - v1
Checksum:i54C6451531537478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001874 Genomic DNA. Translation: ADG89141.1.
RefSeqiWP_013132674.1. NC_014165.1.
YP_003653034.1. NC_014165.1.

Genome annotation databases

EnsemblBacteriaiADG89141; ADG89141; Tbis_2438.
KEGGitbi:Tbis_2438.
PATRICi38288031. VBITheBis80272_2547.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001874 Genomic DNA. Translation: ADG89141.1.
RefSeqiWP_013132674.1. NC_014165.1.
YP_003653034.1. NC_014165.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi469371.Tbis_2438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADG89141; ADG89141; Tbis_2438.
KEGGitbi:Tbis_2438.
PATRICi38288031. VBITheBis80272_2547.

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK10747.
OMAiGRPRPFQ.

Enzyme and pathway databases

BioCyciTBIS469371:GHSI-2473-MONOMER.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51Imported.

Entry informationi

Entry nameiD6Y4G5_THEBD
AccessioniPrimary (citable) accession number: D6Y4G5
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.