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D6XST1

- D6XST1_BACIE

UniProt

D6XST1 - D6XST1_BACIE

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Protein

Malate dehydrogenase

Gene
mdh, Bsel_1355
Organism
Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NAD By similarityUniRule annotation
Binding sitei87 – 871Substrate By similarityUniRule annotation
Binding sitei93 – 931Substrate By similarityUniRule annotation
Binding sitei100 – 1001NAD By similarityUniRule annotation
Binding sitei125 – 1251Substrate By similarityUniRule annotation
Binding sitei156 – 1561Substrate By similarityUniRule annotation
Active sitei180 – 1801Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD By similarityUniRule annotation
Nucleotide bindingi123 – 1253NAD By similarityUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotations

Keywords - Ligandi

NADUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBSEL439292:GHLG-1417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Bsel_1355Imported
OrganismiBacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)Imported
Taxonomic identifieri439292 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000271: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491Phosphoserine By similarityUniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6XST1.
SMRiD6XST1. Positions 5-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

D6XST1-1 [UniParc]FASTAAdd to Basket

« Hide

MAIKRRKITV VGGGFTGTTT ALMTAQKELG DVVLIDIPKM EDPTKGKALD    50
MMEASPVQGF DSKITGTSDY KDTAGSDIVV ITAGIPRKPG MSRDDLVSTN 100
AGIMKSVTQE IVKYSPDCYI IVLTNPVDAM TYTVFKESGF PKNRVIGQSG 150
VLDTARFNTF VAEELNVSVE DVTGFVLGGH GDDMVPMLRY SFAGGIPLEK 200
LIDKERLEAI VERTRKGGGE IVNLLGNGSA YYAPAASIVQ MVEAILKDKK 250
RILPTIAYLE GEYGYSDLYL GVPTVIGGDG IEQVFELDLN DDEKAALDKS 300
VASVKKVMEI L 311
Length:311
Mass (Da):33,506
Last modified:August 10, 2010 - v1
Checksum:i4B474E2B1A02CF8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001791 Genomic DNA. Translation: ADH98867.1.
RefSeqiYP_003699433.1. NC_014219.1.

Genome annotation databases

EnsemblBacteriaiADH98867; ADH98867; Bsel_1355.
GeneIDi9263927.
KEGGibse:Bsel_1355.
PATRICi38122005. VBIBacSel78655_1448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001791 Genomic DNA. Translation: ADH98867.1 .
RefSeqi YP_003699433.1. NC_014219.1.

3D structure databases

ProteinModelPortali D6XST1.
SMRi D6XST1. Positions 5-311.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADH98867 ; ADH98867 ; Bsel_1355 .
GeneIDi 9263927.
KEGGi bse:Bsel_1355.
PATRICi 38122005. VBIBacSel78655_1448.

Phylogenomic databases

HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.

Enzyme and pathway databases

BioCyci BSEL439292:GHLG-1417-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Bacillus selenitireducens MLS10."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Stolz J.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700615 / DSM 15326 / MLS10.

Entry informationi

Entry nameiD6XST1_BACIE
AccessioniPrimary (citable) accession number: D6XST1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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