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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei100 – 1001NADUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei180 – 1801Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADUniRule annotation
Nucleotide bindingi123 – 1253NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBSEL439292:GHLG-1417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Bsel_1355Imported
OrganismiBacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)Imported
Taxonomic identifieri439292 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesSporolactobacillaceaeunclassified Sporolactobacillaceae
ProteomesiUP000000271: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineUniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD6XST1.
SMRiD6XST1. Positions 5-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiCDQKKMF.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

D6XST1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKRRKITV VGGGFTGTTT ALMTAQKELG DVVLIDIPKM EDPTKGKALD
60 70 80 90 100
MMEASPVQGF DSKITGTSDY KDTAGSDIVV ITAGIPRKPG MSRDDLVSTN
110 120 130 140 150
AGIMKSVTQE IVKYSPDCYI IVLTNPVDAM TYTVFKESGF PKNRVIGQSG
160 170 180 190 200
VLDTARFNTF VAEELNVSVE DVTGFVLGGH GDDMVPMLRY SFAGGIPLEK
210 220 230 240 250
LIDKERLEAI VERTRKGGGE IVNLLGNGSA YYAPAASIVQ MVEAILKDKK
260 270 280 290 300
RILPTIAYLE GEYGYSDLYL GVPTVIGGDG IEQVFELDLN DDEKAALDKS
310
VASVKKVMEI L
Length:311
Mass (Da):33,506
Last modified:August 10, 2010 - v1
Checksum:i4B474E2B1A02CF8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001791 Genomic DNA. Translation: ADH98867.1.
RefSeqiWP_013172291.1. NC_014219.1.
YP_003699433.1. NC_014219.1.

Genome annotation databases

EnsemblBacteriaiADH98867; ADH98867; Bsel_1355.
GeneIDi9263927.
KEGGibse:Bsel_1355.
PATRICi38122005. VBIBacSel78655_1448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001791 Genomic DNA. Translation: ADH98867.1.
RefSeqiWP_013172291.1. NC_014219.1.
YP_003699433.1. NC_014219.1.

3D structure databases

ProteinModelPortaliD6XST1.
SMRiD6XST1. Positions 5-311.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADH98867; ADH98867; Bsel_1355.
GeneIDi9263927.
KEGGibse:Bsel_1355.
PATRICi38122005. VBIBacSel78655_1448.

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiCDQKKMF.

Enzyme and pathway databases

BioCyciBSEL439292:GHLG-1417-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Bacillus selenitireducens MLS10."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Stolz J.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700615 / DSM 15326 / MLS10Imported.

Entry informationi

Entry nameiD6XST1_BACIE
AccessioniPrimary (citable) accession number: D6XST1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: February 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.