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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBSEL439292:G1GLR-1420-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Bsel_1355Imported
OrganismiBacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)Imported
Taxonomic identifieri439292 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesSporolactobacillaceaeunclassified Sporolactobacillaceae
Proteomesi
  • UP000000271 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi439292.Bsel_1355

Structurei

3D structure databases

ProteinModelPortaliD6XST1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 147Ldh_1_NInterPro annotationAdd BLAST141
Domaini151 – 309Ldh_1_CInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

D6XST1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKRRKITV VGGGFTGTTT ALMTAQKELG DVVLIDIPKM EDPTKGKALD
60 70 80 90 100
MMEASPVQGF DSKITGTSDY KDTAGSDIVV ITAGIPRKPG MSRDDLVSTN
110 120 130 140 150
AGIMKSVTQE IVKYSPDCYI IVLTNPVDAM TYTVFKESGF PKNRVIGQSG
160 170 180 190 200
VLDTARFNTF VAEELNVSVE DVTGFVLGGH GDDMVPMLRY SFAGGIPLEK
210 220 230 240 250
LIDKERLEAI VERTRKGGGE IVNLLGNGSA YYAPAASIVQ MVEAILKDKK
260 270 280 290 300
RILPTIAYLE GEYGYSDLYL GVPTVIGGDG IEQVFELDLN DDEKAALDKS
310
VASVKKVMEI L
Length:311
Mass (Da):33,506
Last modified:August 10, 2010 - v1
Checksum:i4B474E2B1A02CF8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001791 Genomic DNA Translation: ADH98867.1
RefSeqiWP_013172291.1, NC_014219.1

Genome annotation databases

EnsemblBacteriaiADH98867; ADH98867; Bsel_1355
KEGGibse:Bsel_1355

Similar proteinsi

Entry informationi

Entry nameiD6XST1_BACIE
AccessioniPrimary (citable) accession number: D6XST1
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health