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D6XST1

- D6XST1_BACIE

UniProt

D6XST1 - D6XST1_BACIE

Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei93 – 931SubstrateUniRule annotation
    Binding sitei100 – 1001NADUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei156 – 1561SubstrateUniRule annotation
    Active sitei180 – 1801Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADUniRule annotation
    Nucleotide bindingi123 – 1253NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBSEL439292:GHLG-1417-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Bsel_1355Imported
    OrganismiBacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS10)Imported
    Taxonomic identifieri439292 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000000271: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei149 – 1491PhosphoserineUniRule annotation

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD6XST1.
    SMRiD6XST1. Positions 5-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D6XST1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKRRKITV VGGGFTGTTT ALMTAQKELG DVVLIDIPKM EDPTKGKALD    50
    MMEASPVQGF DSKITGTSDY KDTAGSDIVV ITAGIPRKPG MSRDDLVSTN 100
    AGIMKSVTQE IVKYSPDCYI IVLTNPVDAM TYTVFKESGF PKNRVIGQSG 150
    VLDTARFNTF VAEELNVSVE DVTGFVLGGH GDDMVPMLRY SFAGGIPLEK 200
    LIDKERLEAI VERTRKGGGE IVNLLGNGSA YYAPAASIVQ MVEAILKDKK 250
    RILPTIAYLE GEYGYSDLYL GVPTVIGGDG IEQVFELDLN DDEKAALDKS 300
    VASVKKVMEI L 311
    Length:311
    Mass (Da):33,506
    Last modified:August 10, 2010 - v1
    Checksum:i4B474E2B1A02CF8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001791 Genomic DNA. Translation: ADH98867.1.
    RefSeqiYP_003699433.1. NC_014219.1.

    Genome annotation databases

    EnsemblBacteriaiADH98867; ADH98867; Bsel_1355.
    GeneIDi9263927.
    KEGGibse:Bsel_1355.
    PATRICi38122005. VBIBacSel78655_1448.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001791 Genomic DNA. Translation: ADH98867.1 .
    RefSeqi YP_003699433.1. NC_014219.1.

    3D structure databases

    ProteinModelPortali D6XST1.
    SMRi D6XST1. Positions 5-311.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADH98867 ; ADH98867 ; Bsel_1355 .
    GeneIDi 9263927.
    KEGGi bse:Bsel_1355.
    PATRICi 38122005. VBIBacSel78655_1448.

    Phylogenomic databases

    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.

    Enzyme and pathway databases

    BioCyci BSEL439292:GHLG-1417-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Bacillus selenitireducens MLS10."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Stolz J.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700615 / DSM 15326 / MLS10Imported.

    Entry informationi

    Entry nameiD6XST1_BACIE
    AccessioniPrimary (citable) accession number: D6XST1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3