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D6XPX8

- D6XPX8_HELPV

UniProt

D6XPX8 - D6XPX8_HELPV

Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

HPV225_0746

Organism
Helicobacter pylori (strain v225d)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Cell wall formation.SAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL637913:GLEV-741-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
    Gene namesi
    Ordered Locus Names:HPV225_0746Imported
    OrganismiHelicobacter pylori (strain v225d)Imported
    Taxonomic identifieri637913 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000007088: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD6XPX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000102494.
    KOiK01921.
    OMAiHNGLLKN.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6XPX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSKYFAQIK EKKLPPLILT CNGLLKNSFL GAKIIELPLV INLVHGGDGE    50
    DGKLASLLEF YRIAFIGPRI EASVLSYNKY LTKLYAKDLG VKALDHVLLN 100
    EKNRANALNL IGFNFPFIIK PSNAGSSLGV SVVKEEKELI YALDGAFEYS 150
    KEVLIEPFIQ GVKEYNLAGC KIKKDFCFSY VEEPNKQEFL DFKQKYLDFS 200
    RNKAPKANLS NALEEQLKEN FKKLYNDLFD GALIRCDFFV IENEVYLNEI 250
    NPIPGSLANY LFDDFKTTLE NLAQSLPKTP KIPIKNSYLL QIQKNK 296
    Length:296
    Mass (Da):33,622
    Last modified:August 10, 2010 - v1
    Checksum:iDCF7F0B927861343
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001582 Genomic DNA. Translation: ADI34822.1.
    RefSeqiYP_005763671.1. NC_017355.1.

    Genome annotation databases

    EnsemblBacteriaiADI34822; ADI34822; HPV225_0746.
    GeneIDi12342339.
    KEGGihpv:HPV225_0746.
    PATRICi43069100. VBIHelPyl5358_0742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001582 Genomic DNA. Translation: ADI34822.1 .
    RefSeqi YP_005763671.1. NC_017355.1.

    3D structure databases

    ProteinModelPortali D6XPX8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADI34822 ; ADI34822 ; HPV225_0746 .
    GeneIDi 12342339.
    KEGGi hpv:HPV225_0746.
    PATRICi 43069100. VBIHelPyl5358_0742.

    Phylogenomic databases

    HOGENOMi HOG000102494.
    KOi K01921.
    OMAi HNGLLKN.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci HPYL637913:GLEV-741-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: v225dImported.

    Entry informationi

    Entry nameiD6XPX8_HELPV
    AccessioniPrimary (citable) accession number: D6XPX8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3