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D6XPX8 (D6XPX8_HELPV) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
D-alanine--D-alanine ligase EMBL ADI34822.1
EC=6.3.2.4 EMBL ADI34822.1
Gene names
Ordered Locus Names:HPV225_0746 EMBL ADI34822.1
OrganismHelicobacter pylori (strain v225d) [Complete proteome] [HAMAP] EMBL ADI34822.1
Taxonomic identifier637913 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905

Subcellular location

Cytoplasm By similarity SAAS SAAS005905.

Sequence similarities

Contains 1 ATP-grasp domain. SAAS SAAS005905

Sequences

Sequence LengthMass (Da)Tools
D6XPX8 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: DCF7F0B927861343

FASTA29633,622
        10         20         30         40         50         60 
MHSKYFAQIK EKKLPPLILT CNGLLKNSFL GAKIIELPLV INLVHGGDGE DGKLASLLEF 

        70         80         90        100        110        120 
YRIAFIGPRI EASVLSYNKY LTKLYAKDLG VKALDHVLLN EKNRANALNL IGFNFPFIIK 

       130        140        150        160        170        180 
PSNAGSSLGV SVVKEEKELI YALDGAFEYS KEVLIEPFIQ GVKEYNLAGC KIKKDFCFSY 

       190        200        210        220        230        240 
VEEPNKQEFL DFKQKYLDFS RNKAPKANLS NALEEQLKEN FKKLYNDLFD GALIRCDFFV 

       250        260        270        280        290 
IENEVYLNEI NPIPGSLANY LFDDFKTTLE NLAQSLPKTP KIPIKNSYLL QIQKNK

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References

[1]"Host-interactive genes in Amerindian Helicobacter pylori diverge from their Old World homologs and mediate inflammatory responses."
Mane S.P., Dominguez-Bello M.G., Blaser M.J., Sobral B.W., Hontecillas R., Skoneczka J., Mohapatra S.K., Crasta O.R., Evans C., Modise T., Shallom S., Shukla M., Varon C., Megraud F., Maldonado-Contreras A.L., Williams K.P., Bassaganya-Riera J.
J. Bacteriol. 192:3078-3092(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: v225d.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001582 Genomic DNA. Translation: ADI34822.1.
RefSeqYP_005763671.1. NC_017355.1.

3D structure databases

ProteinModelPortalD6XPX8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADI34822; ADI34822; HPV225_0746.
GeneID12342339.
KEGGhpv:HPV225_0746.
PATRIC43069100. VBIHelPyl5358_0742.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000102494.
KOK01921.
OMAGNEMIAH.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6XPX8_HELPV
AccessionPrimary (citable) accession number: D6XPX8
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info