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Protein

D-alanine--D-alanine ligase

Gene

HPV225_0746

Organism
Helicobacter pylori (strain v225d)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:HPV225_0746Imported
OrganismiHelicobacter pylori (strain v225d)Imported
Taxonomic identifieri637913 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000007088 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD6XPX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 281ATP-graspInterPro annotationAdd BLAST199

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000102494
KOiK01921
OMAiRCDFFVI

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

D6XPX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSKYFAQIK EKKLPPLILT CNGLLKNSFL GAKIIELPLV INLVHGGDGE
60 70 80 90 100
DGKLASLLEF YRIAFIGPRI EASVLSYNKY LTKLYAKDLG VKALDHVLLN
110 120 130 140 150
EKNRANALNL IGFNFPFIIK PSNAGSSLGV SVVKEEKELI YALDGAFEYS
160 170 180 190 200
KEVLIEPFIQ GVKEYNLAGC KIKKDFCFSY VEEPNKQEFL DFKQKYLDFS
210 220 230 240 250
RNKAPKANLS NALEEQLKEN FKKLYNDLFD GALIRCDFFV IENEVYLNEI
260 270 280 290
NPIPGSLANY LFDDFKTTLE NLAQSLPKTP KIPIKNSYLL QIQKNK
Length:296
Mass (Da):33,622
Last modified:August 10, 2010 - v1
Checksum:iDCF7F0B927861343
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001582 Genomic DNA Translation: ADI34822.1

Genome annotation databases

EnsemblBacteriaiADI34822; ADI34822; HPV225_0746
KEGGihpv:HPV225_0746
PATRICifig|637913.3.peg.742

Similar proteinsi

Entry informationi

Entry nameiD6XPX8_HELPV
AccessioniPrimary (citable) accession number: D6XPX8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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