D6XHE1 (D6XHE1_TRYB2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cysteine peptidase C (CPC) EMBL AAZ11620.1
EC=3.4.22.- EMBL AAZ11620.1

Gene names

ORF Names:

Tb927.6.560 EMBL AAZ11620.1

Organism

Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]

Taxonomic identifier

999953 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Trypanozoon › Trypanosoma brucei › Trypanosoma brucei brucei

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C1 family. RuleBase RU004043

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAZ11620.1
Technical term	3D-structure PDB 4HWY Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D6XHE1 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: E537B0FD5F268EAC	FASTA	340	37,224
	10 20 30 40 50 60 MHLMRACITF CIASTAVVAV NAALVAEDAP VLSKAFVDRV NRLNRGIWKA KYDGVMQNIT 70 80 90 100 110 120 LREAKRLNGV IKKNNNASIL PKRRFTEEEA RAPLPSSFDS AEAWPNCPTI PQIADQSACG 130 140 150 160 170 180 SCWAVAAASA MSDRFCTMGG VQDVHISAGD LLACCSDCGD GCNGGDPDRA WAYFSSTGLV 190 200 210 220 230 240 SDYCQPYPFP HCSHHSKSKN GYPPCSQFNF DTPKCNYTCD DPTIPVVNYR SWTSYALQGE 250 260 270 280 290 300 DDYMRELFFR GPFEVAFDVY EDFIAYNSGV YHHVSGQYLG GHAVRLVGWG TSNGVPYWKI 310 320 330 340 ANSWNTEWGM DGYFLIRRGS SECGIEDGGS AGIPLAPNTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G. , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GUTat10.1 EMBL AAX80461.1.
[2]	El-Sayed N.M., Khalak H., Adams M.D. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GUTat10.1 EMBL AAX80461.1.
[3]	"Comparative genomics of trypanosomatid parasitic protozoa." El-Sayed N.M.A., Myler P.J., Blandin G., Berriman M., Crabtree J., Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C., Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.-N., Wortman J.R., Alsmark U.C.M., Angiuoli S. , Anupama A., Badger J., Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T., Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C., Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L., Shallom J., Silva J.C., Sundaram J., Westenberger S., White O., Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N. Science 309:404-409(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[4]	"The genome of the African trypanosome Trypanosoma brucei." Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A. Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[5]	"Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8." Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G. , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[6]	Haas B., Blandin G., El-Sayed N. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: GUTat10.1 EMBL AAX80461.1.
[7]	"Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser." Redecke L., Nass K., DePonte D.P., White T.A., Rehders D., Barty A., Stellato F., Liang M., Barends T.R., Boutet S., Williams G.J., Messerschmidt M., Seibert M.M., Aquila A., Arnlund D., Bajt S., Barth T., Bogan M.J. , Caleman C., Chao T.C., Doak R.B., Fleckenstein H., Frank M., Fromme R., Galli L., Grotjohann I., Hunter M.S., Johansson L.C., Kassemeyer S., Katona G., Kirian R.A., Koopmann R., Kupitz C., Lomb L., Martin A.V., Mogk S., Neutze R., Shoeman R.L., Steinbrener J., Timneanu N., Wang D., Weierstall U., Zatsepin N.A., Spence J.C., Fromme P., Schlichting I., Duszenko M., Betzel C., Chapman H.N. Science 339:227-230(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC084046 Genomic DNA. Translation: AAX80461.1.
CP000069 Genomic DNA. Translation: AAZ11620.1.

RefSeq

XP_845179.1. XM_840086.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HWY	X-ray	2.10	A	1-340	[»]

ModBase

Search...

Protein family/group databases

MEROPS

C01.098.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3657691.

KEGG

tbr:Tb927.6.560.

Phylogenomic databases

HOGENOM

HOG000241341.

KO

K08572.

OMA

DEHRIME.

Family and domain databases

InterPro

IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015643. Peptidase_C1A_cathepsin-B.
[Graphical view]

PANTHER

PTHR12411. PTHR12411. 1 hit.
PTHR12411:SF16. PTHR12411:SF16. 1 hit.

Pfam

PF00112. Peptidase_C1. 1 hit.
[Graphical view]

PRINTS

PR00705. PAPAIN.

SMART

SM00645. Pept_C1. 1 hit.
[Graphical view]

PROSITE

PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

D6XHE1.

Entry information

Entry name

D6XHE1_TRYB2

Accession

Primary (citable) accession number: D6XHE1

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)