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D6XHE1 (D6XHE1_TRYB2) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=3.4.22.- EMBL AAZ11620.1
Gene names
ORF Names:Tb927.6.560 EMBL AAZ11620.1
OrganismTrypanosoma brucei brucei (strain 927/4 GUTat10.1) [Reference proteome]
Taxonomic identifier999953 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C1 family. RuleBase RU004043

Ontologies

Keywords
   Molecular functionHydrolase EMBL AAZ11620.1
   Technical term3D-structure PDB 4HWY PDB 4N4Z
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) PDB 4N4Z
Glycosylation2161N-linked (GlcNAc...) PDB 4N4Z

Sequences

Sequence LengthMass (Da)Tools
D6XHE1 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: E537B0FD5F268EAC

FASTA34037,224
        10         20         30         40         50         60 
MHLMRACITF CIASTAVVAV NAALVAEDAP VLSKAFVDRV NRLNRGIWKA KYDGVMQNIT 

        70         80         90        100        110        120 
LREAKRLNGV IKKNNNASIL PKRRFTEEEA RAPLPSSFDS AEAWPNCPTI PQIADQSACG 

       130        140        150        160        170        180 
SCWAVAAASA MSDRFCTMGG VQDVHISAGD LLACCSDCGD GCNGGDPDRA WAYFSSTGLV 

       190        200        210        220        230        240 
SDYCQPYPFP HCSHHSKSKN GYPPCSQFNF DTPKCNYTCD DPTIPVVNYR SWTSYALQGE 

       250        260        270        280        290        300 
DDYMRELFFR GPFEVAFDVY EDFIAYNSGV YHHVSGQYLG GHAVRLVGWG TSNGVPYWKI 

       310        320        330        340 
ANSWNTEWGM DGYFLIRRGS SECGIEDGGS AGIPLAPNTA 

« Hide

References

« Hide 'large scale' references
[1]Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G. expand/collapse author list , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GUTat10.1 EMBL AAX80461.1.
[2]El-Sayed N.M., Khalak H., Adams M.D.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GUTat10.1 EMBL AAX80461.1.
[3]"Comparative genomics of trypanosomatid parasitic protozoa."
El-Sayed N.M.A., Myler P.J., Blandin G., Berriman M., Crabtree J., Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C., Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.-N., Wortman J.R., Alsmark U.C.M., Angiuoli S. expand/collapse author list , Anupama A., Badger J., Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T., Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C., Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L., Shallom J., Silva J.C., Sundaram J., Westenberger S., White O., Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.
Science 309:404-409(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[4]"The genome of the African trypanosome Trypanosoma brucei."
Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M. expand/collapse author list , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[5]"Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G. expand/collapse author list , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 927/4 GUTat10.1 EMBL AAZ11620.1.
[6]Haas B., Blandin G., El-Sayed N.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GUTat10.1 EMBL AAX80461.1.
[7]"Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser."
Redecke L., Nass K., DePonte D.P., White T.A., Rehders D., Barty A., Stellato F., Liang M., Barends T.R., Boutet S., Williams G.J., Messerschmidt M., Seibert M.M., Aquila A., Arnlund D., Bajt S., Barth T., Bogan M.J. expand/collapse author list , Caleman C., Chao T.C., Doak R.B., Fleckenstein H., Frank M., Fromme R., Galli L., Grotjohann I., Hunter M.S., Johansson L.C., Kassemeyer S., Katona G., Kirian R.A., Koopmann R., Kupitz C., Lomb L., Martin A.V., Mogk S., Neutze R., Shoeman R.L., Steinbrener J., Timneanu N., Wang D., Weierstall U., Zatsepin N.A., Spence J.C., Fromme P., Schlichting I., Duszenko M., Betzel C., Chapman H.N.
Science 339:227-230(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), GLYCOSYLATION AT ASN-58 AND ASN-216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC084046 Genomic DNA. Translation: AAX80461.1.
CP000069 Genomic DNA. Translation: AAZ11620.1.
RefSeqXP_845179.1. XM_840086.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWYX-ray2.10A1-340[»]
4N4ZX-ray3.30A1-340[»]
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3657691.
KEGGtbr:Tb927.6.560.

Phylogenomic databases

HOGENOMHOG000241341.
KOK08572.
OMADEHRIME.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceD6XHE1.

Entry information

Entry nameD6XHE1_TRYB2
AccessionPrimary (citable) accession number: D6XHE1
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)