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D6XHE1

- D6XHE1_TRYB2

UniProt

D6XHE1 - D6XHE1_TRYB2

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Protein
Submitted name: Cysteine peptidase C (CPC)
Gene
Tb927.6.560
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    HydrolaseImported

    Protein family/group databases

    MEROPSiC01.098.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cysteine peptidase C (CPC)Imported (EC:3.4.22.-Imported)
    Gene namesi
    ORF Names:Tb927.6.560Imported
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
    Taxonomic identifieri999953 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    ProteomesiUP000008524: Chromosome 6

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Imported
    Glycosylationi216 – 2161N-linked (GlcNAc...)Imported

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HWYX-ray2.10A1-340[»]
    4N4ZX-ray3.30A1-340[»]

    Miscellaneous databases

    EvolutionaryTraceiD6XHE1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000241341.
    KOiK08572.
    OMAiELERWMA.

    Family and domain databases

    InterProiIPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015643. Peptidase_C1A_cathepsin-B.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF16. PTHR12411:SF16. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6XHE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLMRACITF CIASTAVVAV NAALVAEDAP VLSKAFVDRV NRLNRGIWKA    50
    KYDGVMQNIT LREAKRLNGV IKKNNNASIL PKRRFTEEEA RAPLPSSFDS 100
    AEAWPNCPTI PQIADQSACG SCWAVAAASA MSDRFCTMGG VQDVHISAGD 150
    LLACCSDCGD GCNGGDPDRA WAYFSSTGLV SDYCQPYPFP HCSHHSKSKN 200
    GYPPCSQFNF DTPKCNYTCD DPTIPVVNYR SWTSYALQGE DDYMRELFFR 250
    GPFEVAFDVY EDFIAYNSGV YHHVSGQYLG GHAVRLVGWG TSNGVPYWKI 300
    ANSWNTEWGM DGYFLIRRGS SECGIEDGGS AGIPLAPNTA 340
    Length:340
    Mass (Da):37,224
    Last modified:June 28, 2011 - v1
    Checksum:iE537B0FD5F268EAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084046 Genomic DNA. Translation: AAX80461.1.
    CP000069 Genomic DNA. Translation: AAZ11620.1.
    RefSeqiXP_845179.1. XM_840086.1.

    Genome annotation databases

    GeneIDi3657691.
    KEGGitbr:Tb927.6.560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084046 Genomic DNA. Translation: AAX80461.1 .
    CP000069 Genomic DNA. Translation: AAZ11620.1 .
    RefSeqi XP_845179.1. XM_840086.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HWY X-ray 2.10 A 1-340 [» ]
    4N4Z X-ray 3.30 A 1-340 [» ]
    ModBasei Search...

    Protein family/group databases

    MEROPSi C01.098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3657691.
    KEGGi tbr:Tb927.6.560.

    Phylogenomic databases

    HOGENOMi HOG000241341.
    KOi K08572.
    OMAi ELERWMA.

    Miscellaneous databases

    EvolutionaryTracei D6XHE1.

    Family and domain databases

    InterProi IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015643. Peptidase_C1A_cathepsin-B.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF16. PTHR12411:SF16. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUTat10.1Imported.
    2. El-Sayed N.M., Khalak H., Adams M.D.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUTat10.1Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    4. "The genome of the African trypanosome Trypanosoma brucei."
      Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
      , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
      Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 927/4 GUTat10.1Imported.
    5. "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
      Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.
      , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    6. Haas B., Blandin G., El-Sayed N.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUTat10.1Imported.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), GLYCOSYLATION AT ASN-58 AND ASN-216.

    Entry informationi

    Entry nameiD6XHE1_TRYB2
    AccessioniPrimary (citable) accession number: D6XHE1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: September 3, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteome

    External Data

    Dasty 3

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