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D6XHE1

- D6XHE1_TRYB2

UniProt

D6XHE1 - D6XHE1_TRYB2

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Protein
Submitted name:

Cysteine peptidase C (CPC)

Gene
Tb927.6.560
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Protein family/group databases

MEROPSiC01.098.

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine peptidase C (CPC)Imported (EC:3.4.22.-Imported)
Gene namesi
ORF Names:Tb927.6.560Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
Taxonomic identifieri999953 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 6

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Imported
Glycosylationi216 – 2161N-linked (GlcNAc...)Imported

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWYX-ray2.10A1-340[»]
4N4ZX-ray3.30A1-340[»]

Miscellaneous databases

EvolutionaryTraceiD6XHE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241341.
KOiK08572.
OMAiELERWMA.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015643. Peptidase_C1A_cathepsin-B.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF16. PTHR12411:SF16. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6XHE1-1 [UniParc]FASTAAdd to Basket

« Hide

MHLMRACITF CIASTAVVAV NAALVAEDAP VLSKAFVDRV NRLNRGIWKA    50
KYDGVMQNIT LREAKRLNGV IKKNNNASIL PKRRFTEEEA RAPLPSSFDS 100
AEAWPNCPTI PQIADQSACG SCWAVAAASA MSDRFCTMGG VQDVHISAGD 150
LLACCSDCGD GCNGGDPDRA WAYFSSTGLV SDYCQPYPFP HCSHHSKSKN 200
GYPPCSQFNF DTPKCNYTCD DPTIPVVNYR SWTSYALQGE DDYMRELFFR 250
GPFEVAFDVY EDFIAYNSGV YHHVSGQYLG GHAVRLVGWG TSNGVPYWKI 300
ANSWNTEWGM DGYFLIRRGS SECGIEDGGS AGIPLAPNTA 340
Length:340
Mass (Da):37,224
Last modified:June 28, 2011 - v1
Checksum:iE537B0FD5F268EAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084046 Genomic DNA. Translation: AAX80461.1.
CP000069 Genomic DNA. Translation: AAZ11620.1.
RefSeqiXP_845179.1. XM_840086.1.

Genome annotation databases

GeneIDi3657691.
KEGGitbr:Tb927.6.560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084046 Genomic DNA. Translation: AAX80461.1 .
CP000069 Genomic DNA. Translation: AAZ11620.1 .
RefSeqi XP_845179.1. XM_840086.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HWY X-ray 2.10 A 1-340 [» ]
4N4Z X-ray 3.30 A 1-340 [» ]
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C01.098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3657691.
KEGGi tbr:Tb927.6.560.

Phylogenomic databases

HOGENOMi HOG000241341.
KOi K08572.
OMAi ELERWMA.

Miscellaneous databases

EvolutionaryTracei D6XHE1.

Family and domain databases

InterProi IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015643. Peptidase_C1A_cathepsin-B.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
PTHR12411:SF16. PTHR12411:SF16. 1 hit.
Pfami PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  2. El-Sayed N.M., Khalak H., Adams M.D.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  4. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  5. "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
    Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.
    , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  6. Haas B., Blandin G., El-Sayed N.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), GLYCOSYLATION AT ASN-58 AND ASN-216.

Entry informationi

Entry nameiD6XHE1_TRYB2
AccessioniPrimary (citable) accession number: D6XHE1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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