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Protein
Submitted name:

Cysteine peptidase C (CPC)

Gene

Tb927.6.560

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Protein family/group databases

MEROPSiC01.098.

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine peptidase C (CPC)Imported (EC:3.4.22.-Imported)
Gene namesi
ORF Names:Tb927.6.560Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 6

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Combined sources
Disulfide bondi107 ↔ 136Combined sources
Disulfide bondi119 ↔ 162Combined sources
Disulfide bondi154 ↔ 215Combined sources
Disulfide bondi155 ↔ 158Combined sources
Disulfide bondi184 ↔ 219Combined sources
Disulfide bondi192 ↔ 205Combined sources
Glycosylationi216 – 2161N-linked (GlcNAc...)Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWYX-ray2.10A1-340[»]
4N4ZX-ray3.30A1-340[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD6XHE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241341.
KOiK08572.
OMAiPVEASYK.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015643. Peptidase_C1A_cathepsin-B.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF16. PTHR12411:SF16. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6XHE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLMRACITF CIASTAVVAV NAALVAEDAP VLSKAFVDRV NRLNRGIWKA
60 70 80 90 100
KYDGVMQNIT LREAKRLNGV IKKNNNASIL PKRRFTEEEA RAPLPSSFDS
110 120 130 140 150
AEAWPNCPTI PQIADQSACG SCWAVAAASA MSDRFCTMGG VQDVHISAGD
160 170 180 190 200
LLACCSDCGD GCNGGDPDRA WAYFSSTGLV SDYCQPYPFP HCSHHSKSKN
210 220 230 240 250
GYPPCSQFNF DTPKCNYTCD DPTIPVVNYR SWTSYALQGE DDYMRELFFR
260 270 280 290 300
GPFEVAFDVY EDFIAYNSGV YHHVSGQYLG GHAVRLVGWG TSNGVPYWKI
310 320 330 340
ANSWNTEWGM DGYFLIRRGS SECGIEDGGS AGIPLAPNTA
Length:340
Mass (Da):37,224
Last modified:June 28, 2011 - v1
Checksum:iE537B0FD5F268EAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084046 Genomic DNA. Translation: AAX80461.1.
CP000069 Genomic DNA. Translation: AAZ11620.1.
RefSeqiXP_845179.1. XM_840086.1.

Genome annotation databases

GeneIDi3657691.
KEGGitbr:Tb927.6.560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084046 Genomic DNA. Translation: AAX80461.1.
CP000069 Genomic DNA. Translation: AAZ11620.1.
RefSeqiXP_845179.1. XM_840086.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HWYX-ray2.10A1-340[»]
4N4ZX-ray3.30A1-340[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3657691.
KEGGitbr:Tb927.6.560.

Phylogenomic databases

HOGENOMiHOG000241341.
KOiK08572.
OMAiPVEASYK.

Miscellaneous databases

EvolutionaryTraceiD6XHE1.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015643. Peptidase_C1A_cathepsin-B.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF16. PTHR12411:SF16. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. El-Sayed N.M., Khalak H., Adams M.D.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  4. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  5. Haas B., Blandin G., El-Sayed N.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS), ACTIVE SITE, GLYCOSYLATION AT ASN-58 AND ASN-216.
  7. "Serial crystallography on in vivo grown microcrystals using synchrotron radiation."
    Gati C., Bourenkov G., Klinge M., Rehders D., Stellato F., Oberthur D., Yefanov O., Sommer B.P., Mogk S., Duszenko M., Betzel C., Schneider T.R., Chapman H.N., Redecke L.
    IUCrJ 1:87-94(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS), ACTIVE SITE, GLYCOSYLATION AT ASN-58 AND ASN-216.

Entry informationi

Entry nameiD6XHE1_TRYB2
AccessioniPrimary (citable) accession number: D6XHE1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.