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Protein

Proteasome subunit alpha type

Gene

TcasGA2_TC000258

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
ORF Names:TcasGA2_TC000258Imported
OrganismiTribolium castaneum (Red flour beetle)Imported
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
Proteomesi
  • UP000007266 Componenti: Linkage group 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiD6WBQ6.

Interactioni

Subunit structurei

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi7070.TC000258-PA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863. Eukaryota.
COG0638. LUCA.
InParanoidiD6WBQ6.
KOiK02725.
OMAiFMKQQCL.
PhylomeDBiD6WBQ6.

Family and domain databases

CDDicd03749. proteasome_alpha_type_1. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR035144. Proteasome_alpha1.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF12. PTHR11599:SF12. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D6WBQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDSDV TVWSPQGRLH QVEYAMEAVN LGSATVGLKS KTHAVLIALK
60 70 80 90 100
RASSELSAYQ KKIINIDDHI GITISGLTAD ARILSRYMRT ECLNYKYSHD
110 120 130 140 150
THLPLNRLIS QLGNKMQLCT QRYDRRPYGV GLLVAGYDDQ GAHIYQTCPS
160 170 180 190 200
ANYYDCKAMS IGARSQSART YLEKHLEELS SCSLEELIKH GLRALRDTLP
210 220 230 240 250
PEVDLTIKNV SIGYVGKGQS FKILVDDETG PYLAMIQGEE RRGGGAQEPP
260 270
AGPLRDEAGD QDQGPRDPVP AVAMDTE
Length:277
Mass (Da):30,705
Last modified:August 10, 2010 - v1
Checksum:iA4A8B1EFF371561E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ971313 Genomic DNA. Translation: EEZ97876.1.
RefSeqiXP_966973.1. XM_961880.4.

Genome annotation databases

EnsemblMetazoaiTC000258_001; TC000258_001; TC000258.
GeneIDi655339.
KEGGitca:655339.

Similar proteinsi

Entry informationi

Entry nameiD6WBQ6_TRICA
AccessioniPrimary (citable) accession number: D6WBQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported