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D6WBL2

- D6WBL2_TRICA

UniProt

D6WBL2 - D6WBL2_TRICA

Protein

DNA ligase

Gene

TcasGA2_TC004862

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:TcasGA2_TC004862Imported
    OrganismiTribolium castaneum (Red flour beetle)Imported
    Taxonomic identifieri7070 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
    ProteomesiUP000007266: Linkage group 2

    Structurei

    3D structure databases

    ProteinModelPortaliD6WBL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10776.
    OMAiLFSEMKH.
    OrthoDBiEOG7BKCT2.
    PhylomeDBiD6WBL2.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6WBL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDELVEKPF LVEVAKQGRA VCKKCKQKCA QGELRIAKLV ANPFGEGKMK    50
    NWHHVNCLFE VFLKQRPTTK RIDDPVEDID GWVLLDDEQK SDILKRVEEC 100
    NSFFETKHGV KPSPKKTPQE AKPSTSSKDS SGPVIQFDPS HKDNQFREFR 150
    RVVADISNVS SYLEKTSIVS KMFTKGSDGT GFKGDIVLWC RLLLPGFVKR 200
    IYNLQSKQLV KLFSKIFHCD QDAMLEHLEQ GDVSETIQVF YERSKSFKPV 250
    KKSTLTLQQV DEFLQDLTNL TKEEEQTAHL KTFASKCTAN DLKIVIRLIK 300
    HDLRMNAGAK HILDGVHPDA YQAFQSSRDI KAVIDRCLKD KGTKARIELM 350
    TPVLPMLAEA CKSVEQAMKK CPNGMYSEIK YDGERVQVHK QGSEFKYFSR 400
    SLKPVLPHKV AHFKNYIPQA FPHGTDLILD SEILMIDTQT GKPLPFGTLG 450
    IHKKSEFKDA SVCLFVFDCI YYNGDVLTDK PISFRKKILK ENMTEIPNHI 500
    VFSEMEEIHD PNDLTQMIAK VLKLGLEGLV LKDITSVYEP GKRHWLKVKK 550
    DYLFGGAMAD SADLIVLGAW YGTGKKGGIM SIFLMGCYDE ANDRFCTVSK 600
    VSTGHDDKTL EKLQTELDMV KISSDPAKVP DWLHCTKTMV PDFVARDPKK 650
    QPVWEITGAE FTKHEVHTAD GISIRFPRVT KIRDDKCWQS ATSLKELKVL 700
    FAKSKEHTDV SLLLQGTAES SPKKQKTLES FVKKRGSEDP QSSNSKKVKK 750
    EPKTVKIINP LPDYFHNIKV VLEDKVREKQ WDLIRYFIAY GGQICKHGES 800
    ENATHMIHLN SMVPEIDQCN PDVKHVTVDW IKNCVVNESV CDYRPFVVRW 850
    KPS 853
    Length:853
    Mass (Da):97,112
    Last modified:August 10, 2010 - v1
    Checksum:i5C548E0015A89408
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000277 Genomic DNA. Translation: EEZ99344.1.
    RefSeqiXP_967954.1. XM_962861.2.

    Genome annotation databases

    EnsemblMetazoaiTCOGS2:TC004862-RA; TCOGS2:TC004862-PA; TCOGS2:TC004862.
    GeneIDi656322.
    KEGGitca:656322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000277 Genomic DNA. Translation: EEZ99344.1 .
    RefSeqi XP_967954.1. XM_962861.2.

    3D structure databases

    ProteinModelPortali D6WBL2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai TCOGS2:TC004862-RA ; TCOGS2:TC004862-PA ; TCOGS2:TC004862 .
    GeneIDi 656322.
    KEGGi tca:656322.

    Phylogenomic databases

    KOi K10776.
    OMAi LFSEMKH.
    OrthoDBi EOG7BKCT2.
    PhylomeDBi D6WBL2.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF52113. SSF52113. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the model beetle and pest Tribolium castaneum."
      Tribolium Genome Sequencing Consortium
      Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
      , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
      Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Georgia GA2Imported.
    2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
      Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
      Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: Georgia GA2Imported.

    Entry informationi

    Entry nameiD6WBL2_TRICA
    AccessioniPrimary (citable) accession number: D6WBL2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3