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D6WBL2

- D6WBL2_TRICA

UniProt

D6WBL2 - D6WBL2_TRICA

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Protein

DNA ligase

Gene

TcasGA2_TC004862

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TcasGA2_TC004862Imported
OrganismiTribolium castaneum (Red flour beetle)Imported
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
ProteomesiUP000007266: Linkage group 2

Structurei

3D structure databases

ProteinModelPortaliD6WBL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiD6WBL2.
KOiK10776.
OMAiLFSEMKH.
OrthoDBiEOG7BKCT2.
PhylomeDBiD6WBL2.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6WBL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDELVEKPF LVEVAKQGRA VCKKCKQKCA QGELRIAKLV ANPFGEGKMK
60 70 80 90 100
NWHHVNCLFE VFLKQRPTTK RIDDPVEDID GWVLLDDEQK SDILKRVEEC
110 120 130 140 150
NSFFETKHGV KPSPKKTPQE AKPSTSSKDS SGPVIQFDPS HKDNQFREFR
160 170 180 190 200
RVVADISNVS SYLEKTSIVS KMFTKGSDGT GFKGDIVLWC RLLLPGFVKR
210 220 230 240 250
IYNLQSKQLV KLFSKIFHCD QDAMLEHLEQ GDVSETIQVF YERSKSFKPV
260 270 280 290 300
KKSTLTLQQV DEFLQDLTNL TKEEEQTAHL KTFASKCTAN DLKIVIRLIK
310 320 330 340 350
HDLRMNAGAK HILDGVHPDA YQAFQSSRDI KAVIDRCLKD KGTKARIELM
360 370 380 390 400
TPVLPMLAEA CKSVEQAMKK CPNGMYSEIK YDGERVQVHK QGSEFKYFSR
410 420 430 440 450
SLKPVLPHKV AHFKNYIPQA FPHGTDLILD SEILMIDTQT GKPLPFGTLG
460 470 480 490 500
IHKKSEFKDA SVCLFVFDCI YYNGDVLTDK PISFRKKILK ENMTEIPNHI
510 520 530 540 550
VFSEMEEIHD PNDLTQMIAK VLKLGLEGLV LKDITSVYEP GKRHWLKVKK
560 570 580 590 600
DYLFGGAMAD SADLIVLGAW YGTGKKGGIM SIFLMGCYDE ANDRFCTVSK
610 620 630 640 650
VSTGHDDKTL EKLQTELDMV KISSDPAKVP DWLHCTKTMV PDFVARDPKK
660 670 680 690 700
QPVWEITGAE FTKHEVHTAD GISIRFPRVT KIRDDKCWQS ATSLKELKVL
710 720 730 740 750
FAKSKEHTDV SLLLQGTAES SPKKQKTLES FVKKRGSEDP QSSNSKKVKK
760 770 780 790 800
EPKTVKIINP LPDYFHNIKV VLEDKVREKQ WDLIRYFIAY GGQICKHGES
810 820 830 840 850
ENATHMIHLN SMVPEIDQCN PDVKHVTVDW IKNCVVNESV CDYRPFVVRW

KPS
Length:853
Mass (Da):97,112
Last modified:August 10, 2010 - v1
Checksum:i5C548E0015A89408
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000277 Genomic DNA. Translation: EEZ99344.1.
RefSeqiXP_967954.1. XM_962861.2.

Genome annotation databases

EnsemblMetazoaiTC004862-RA; TC004862-PA; TC004862.
GeneIDi656322.
KEGGitca:656322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000277 Genomic DNA. Translation: EEZ99344.1 .
RefSeqi XP_967954.1. XM_962861.2.

3D structure databases

ProteinModelPortali D6WBL2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TC004862-RA ; TC004862-PA ; TC004862 .
GeneIDi 656322.
KEGGi tca:656322.

Phylogenomic databases

InParanoidi D6WBL2.
KOi K10776.
OMAi LFSEMKH.
OrthoDBi EOG7BKCT2.
PhylomeDBi D6WBL2.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the model beetle and pest Tribolium castaneum."
    Tribolium Genome Sequencing Consortium
    Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
    , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
    Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Georgia GA2Imported.
  2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
    Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
    Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: Georgia GA2Imported.

Entry informationi

Entry nameiD6WBL2_TRICA
AccessioniPrimary (citable) accession number: D6WBL2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3