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D6WBL2

- D6WBL2_TRICA

UniProt

D6WBL2 - D6WBL2_TRICA

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Protein
DNA ligase
Gene
TcasGA2_TC004862
Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TcasGA2_TC004862Imported
OrganismiTribolium castaneum (Red flour beetle)
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
ProteomesiUP000007266: Linkage group 2

Structurei

3D structure databases

ProteinModelPortaliD6WBL2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10776.
OMAiLFSEMKH.
OrthoDBiEOG7BKCT2.
PhylomeDBiD6WBL2.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6WBL2-1 [UniParc]FASTAAdd to Basket

« Hide

MSDELVEKPF LVEVAKQGRA VCKKCKQKCA QGELRIAKLV ANPFGEGKMK    50
NWHHVNCLFE VFLKQRPTTK RIDDPVEDID GWVLLDDEQK SDILKRVEEC 100
NSFFETKHGV KPSPKKTPQE AKPSTSSKDS SGPVIQFDPS HKDNQFREFR 150
RVVADISNVS SYLEKTSIVS KMFTKGSDGT GFKGDIVLWC RLLLPGFVKR 200
IYNLQSKQLV KLFSKIFHCD QDAMLEHLEQ GDVSETIQVF YERSKSFKPV 250
KKSTLTLQQV DEFLQDLTNL TKEEEQTAHL KTFASKCTAN DLKIVIRLIK 300
HDLRMNAGAK HILDGVHPDA YQAFQSSRDI KAVIDRCLKD KGTKARIELM 350
TPVLPMLAEA CKSVEQAMKK CPNGMYSEIK YDGERVQVHK QGSEFKYFSR 400
SLKPVLPHKV AHFKNYIPQA FPHGTDLILD SEILMIDTQT GKPLPFGTLG 450
IHKKSEFKDA SVCLFVFDCI YYNGDVLTDK PISFRKKILK ENMTEIPNHI 500
VFSEMEEIHD PNDLTQMIAK VLKLGLEGLV LKDITSVYEP GKRHWLKVKK 550
DYLFGGAMAD SADLIVLGAW YGTGKKGGIM SIFLMGCYDE ANDRFCTVSK 600
VSTGHDDKTL EKLQTELDMV KISSDPAKVP DWLHCTKTMV PDFVARDPKK 650
QPVWEITGAE FTKHEVHTAD GISIRFPRVT KIRDDKCWQS ATSLKELKVL 700
FAKSKEHTDV SLLLQGTAES SPKKQKTLES FVKKRGSEDP QSSNSKKVKK 750
EPKTVKIINP LPDYFHNIKV VLEDKVREKQ WDLIRYFIAY GGQICKHGES 800
ENATHMIHLN SMVPEIDQCN PDVKHVTVDW IKNCVVNESV CDYRPFVVRW 850
KPS 853
Length:853
Mass (Da):97,112
Last modified:August 10, 2010 - v1
Checksum:i5C548E0015A89408
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000277 Genomic DNA. Translation: EEZ99344.1.
RefSeqiXP_967954.1. XM_962861.2.

Genome annotation databases

EnsemblMetazoaiTCOGS2:TC004862-RA; TCOGS2:TC004862-PA; TCOGS2:TC004862.
GeneIDi656322.
KEGGitca:656322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000277 Genomic DNA. Translation: EEZ99344.1 .
RefSeqi XP_967954.1. XM_962861.2.

3D structure databases

ProteinModelPortali D6WBL2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TCOGS2:TC004862-RA ; TCOGS2:TC004862-PA ; TCOGS2:TC004862 .
GeneIDi 656322.
KEGGi tca:656322.

Phylogenomic databases

KOi K10776.
OMAi LFSEMKH.
OrthoDBi EOG7BKCT2.
PhylomeDBi D6WBL2.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the model beetle and pest Tribolium castaneum."
    Tribolium Genome Sequencing Consortium
    Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
    , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
    Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Georgia GA2Imported.
  2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
    Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
    Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: Georgia GA2Imported.

Entry informationi

Entry nameiD6WBL2_TRICA
AccessioniPrimary (citable) accession number: D6WBL2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi