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D6W734 (D6W734_TRICA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:TcasGA2_TC013593 EMBL EFA11417.1
OrganismTribolium castaneum (Red flour beetle) [Complete proteome]
Taxonomic identifier7070 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium

Protein attributes

Sequence length1345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
D6W734 [UniParc].

Last modified August 10, 2010. Version 1.
Checksum: 58A93A20557ED398

FASTA1,345152,309
        10         20         30         40         50         60 
MCALELKLHS PAGAEPVLYT WPLTSGRGND KHDGALEIVE TIRWVCEDLP ELKLPLENNI 

        70         80         90        100        110        120 
LCDYDTKDYE SMKNLCDRFN RAIDSVVALE KGTSLIAQRL NKYPSRGLLR HILQQTYNAA 

       130        140        150        160        170        180 
VTDPEKLNQY EPFSPEVYGE TSYDLVCQMI DQIDVTSDDV FIDLGSGVGQ VVLQMAAATP 

       190        200        210        220        230        240 
CKVCFGIERA EVPSRYAEAM NKYFRTWMSW YGKRYGEYKL IRSDFLTEEH REKINQATIV 

       250        260        270        280        290        300 
FVNNFAFGPA VDHQLKERFA DLKDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP 

       310        320        330        340        350        360 
MKGSVSWTGK PVSYYLHRID RTKLERYFQR MKKPQLKNGD DNDNSRSARE KAKRDLSKQL 

       370        380        390        400        410        420 
GSSSDSDYDD QDSNYGPTTR KAWSDYCSTK GKSSQSEEEG NNKNGKRQPK KLRRKIQRGK 

       430        440        450        460        470        480 
NQANGEKAQK TGPKSRRGRV KKGGKPKKTI KINGLDLLHN ETLLSTSPQA IGKKLPPAPG 

       490        500        510        520        530        540 
CVDQQLTALS TELVHNELDI PQAPASTPYG LQILLDMFRA QYMQMLNQMK QPTYKTSVEN 

       550        560        570        580        590        600 
HIKQEKERNK KLQNRAAQLE KQIKVLIDDS VALLKARMSE LGINATSPVD LLAKAKEIVC 

       610        620        630        640        650        660 
RHKELQAKAS KLQGQVASLE QEQNNLVIQR QQEIVEKYNG RDTCHDLSPI ATQEYILREI 

       670        680        690        700        710        720 
SSTLAHRKKL HNQVSRLEGE LLSLEKANEE RKQAQALATR QQQTPSTKSS RKSREYRARS 

       730        740        750        760        770        780 
QDWPDVPDIA KIEEQNPEIL AQKILETGRK IEASKMSANC RKINLVRNNM PAPLPVPKRQ 

       790        800        810        820        830        840 
KTSYSLPPTQ SSATRAQEPP RLADFEDRLK SIITSALNED QQNRNRAQSA YQQQQNYVNF 

       850        860        870        880        890        900 
QNDKHKFAKY NRCETVVKQN EERSFAQQEG LAGMMESYRT EVPKVSPHVA RQVAPEQPDY 

       910        920        930        940        950        960 
TQVSPAKLAL RRHLSQEKLA AQHHSFSSSD GIVATRTIGD LMSGEIERTL EISNQSIINA 

       970        980        990       1000       1010       1020 
AVDMSDIQGT TTLTSRSVVN VNLPPRPERV KVNNETKKAE PMRQVYSPIS RPSSTEGTTT 

      1030       1040       1050       1060       1070       1080 
PSQLNCLRTT VSGLEGLAYT PLPRADIRPY HESYFTDVKP PIEGEIRGNF VAEGLAASLQ 

      1090       1100       1110       1120       1130       1140 
ARVLSGPQIK EEVDVYDRRS CVQPNVLYQD HNGSTIKSEG VSDCQYKRES PIIQGPIRNS 

      1150       1160       1170       1180       1190       1200 
LKRRLVDEQE PARVRKCNEE DADVEEEGEE SKWQDRISSG FDRLVAFAST ELDKRRRSTE 

      1210       1220       1230       1240       1250       1260 
GSDSCNTSPD SGIGHGDLPP SSLTVSTPAK QALKLNPNSK PTLFKMPNKI YLESPPLIGE 

      1270       1280       1290       1300       1310       1320 
SGNDESGPPR TPSPSSLISV PLNYSPEPPN EKSQPRLNPA LLKYQREDKK VKPDQHYKKK 

      1330       1340 
FYYREQWRDD SWQNRDHDRY CSWKN 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the model beetle and pest Tribolium castaneum."
Tribolium Genome Sequencing Consortium
Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D. expand/collapse author list , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Georgia GA2 EMBL EFA11417.1.
[2]"BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Georgia GA2 EMBL EFA11417.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000276 Genomic DNA. Translation: EFA11417.1.
RefSeqXP_001813884.1. XM_001813832.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaTCOGS2:TC013593-RA; TCOGS2:TC013593-PA; TCOGS2:TC013593.
GeneID660658.
KEGGtca:660658.

Phylogenomic databases

KOK11427.
OMAVYSPISR.
OrthoDBEOG7W6WJV.
PhylomeDBD6W734.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD6W734_TRICA
AccessionPrimary (citable) accession number: D6W734
Entry history
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)