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D6W734

- D6W734_TRICA

UniProt

D6W734 - D6W734_TRICA

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

TcasGA2_TC013593

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:TcasGA2_TC013593Imported
    OrganismiTribolium castaneum (Red flour beetle)Imported
    Taxonomic identifieri7070 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
    ProteomesiUP000007266: Linkage group 1

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OMAiVYSPISR.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiD6W734.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6W734-1 [UniParc]FASTAAdd to Basket

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    MCALELKLHS PAGAEPVLYT WPLTSGRGND KHDGALEIVE TIRWVCEDLP     50
    ELKLPLENNI LCDYDTKDYE SMKNLCDRFN RAIDSVVALE KGTSLIAQRL 100
    NKYPSRGLLR HILQQTYNAA VTDPEKLNQY EPFSPEVYGE TSYDLVCQMI 150
    DQIDVTSDDV FIDLGSGVGQ VVLQMAAATP CKVCFGIERA EVPSRYAEAM 200
    NKYFRTWMSW YGKRYGEYKL IRSDFLTEEH REKINQATIV FVNNFAFGPA 250
    VDHQLKERFA DLKDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP 300
    MKGSVSWTGK PVSYYLHRID RTKLERYFQR MKKPQLKNGD DNDNSRSARE 350
    KAKRDLSKQL GSSSDSDYDD QDSNYGPTTR KAWSDYCSTK GKSSQSEEEG 400
    NNKNGKRQPK KLRRKIQRGK NQANGEKAQK TGPKSRRGRV KKGGKPKKTI 450
    KINGLDLLHN ETLLSTSPQA IGKKLPPAPG CVDQQLTALS TELVHNELDI 500
    PQAPASTPYG LQILLDMFRA QYMQMLNQMK QPTYKTSVEN HIKQEKERNK 550
    KLQNRAAQLE KQIKVLIDDS VALLKARMSE LGINATSPVD LLAKAKEIVC 600
    RHKELQAKAS KLQGQVASLE QEQNNLVIQR QQEIVEKYNG RDTCHDLSPI 650
    ATQEYILREI SSTLAHRKKL HNQVSRLEGE LLSLEKANEE RKQAQALATR 700
    QQQTPSTKSS RKSREYRARS QDWPDVPDIA KIEEQNPEIL AQKILETGRK 750
    IEASKMSANC RKINLVRNNM PAPLPVPKRQ KTSYSLPPTQ SSATRAQEPP 800
    RLADFEDRLK SIITSALNED QQNRNRAQSA YQQQQNYVNF QNDKHKFAKY 850
    NRCETVVKQN EERSFAQQEG LAGMMESYRT EVPKVSPHVA RQVAPEQPDY 900
    TQVSPAKLAL RRHLSQEKLA AQHHSFSSSD GIVATRTIGD LMSGEIERTL 950
    EISNQSIINA AVDMSDIQGT TTLTSRSVVN VNLPPRPERV KVNNETKKAE 1000
    PMRQVYSPIS RPSSTEGTTT PSQLNCLRTT VSGLEGLAYT PLPRADIRPY 1050
    HESYFTDVKP PIEGEIRGNF VAEGLAASLQ ARVLSGPQIK EEVDVYDRRS 1100
    CVQPNVLYQD HNGSTIKSEG VSDCQYKRES PIIQGPIRNS LKRRLVDEQE 1150
    PARVRKCNEE DADVEEEGEE SKWQDRISSG FDRLVAFAST ELDKRRRSTE 1200
    GSDSCNTSPD SGIGHGDLPP SSLTVSTPAK QALKLNPNSK PTLFKMPNKI 1250
    YLESPPLIGE SGNDESGPPR TPSPSSLISV PLNYSPEPPN EKSQPRLNPA 1300
    LLKYQREDKK VKPDQHYKKK FYYREQWRDD SWQNRDHDRY CSWKN 1345
    Length:1,345
    Mass (Da):152,309
    Last modified:August 10, 2010 - v1
    Checksum:i58A93A20557ED398
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000276 Genomic DNA. Translation: EFA11417.1.

    Genome annotation databases

    EnsemblMetazoaiTCOGS2:TC013593-RA; TCOGS2:TC013593-PA; TCOGS2:TC013593.
    KEGGitca:660658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000276 Genomic DNA. Translation: EFA11417.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai TCOGS2:TC013593-RA ; TCOGS2:TC013593-PA ; TCOGS2:TC013593 .
    KEGGi tca:660658.

    Phylogenomic databases

    KOi K11427.
    OMAi VYSPISR.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi D6W734.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the model beetle and pest Tribolium castaneum."
      Tribolium Genome Sequencing Consortium
      Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
      , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
      Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Georgia GA2Imported.
    2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
      Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
      Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: Georgia GA2Imported.

    Entry informationi

    Entry nameiD6W734_TRICA
    AccessioniPrimary (citable) accession number: D6W734
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3