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D6W734

- D6W734_TRICA

UniProt

D6W734 - D6W734_TRICA

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

TcasGA2_TC013593

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:TcasGA2_TC013593Imported
OrganismiTribolium castaneum (Red flour beetle)Imported
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
ProteomesiUP000007266: Linkage group 1

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

InParanoidiD6W734.
KOiK11427.
OMAiVYSPISR.
OrthoDBiEOG7W6WJV.
PhylomeDBiD6W734.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6W734-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCALELKLHS PAGAEPVLYT WPLTSGRGND KHDGALEIVE TIRWVCEDLP
60 70 80 90 100
ELKLPLENNI LCDYDTKDYE SMKNLCDRFN RAIDSVVALE KGTSLIAQRL
110 120 130 140 150
NKYPSRGLLR HILQQTYNAA VTDPEKLNQY EPFSPEVYGE TSYDLVCQMI
160 170 180 190 200
DQIDVTSDDV FIDLGSGVGQ VVLQMAAATP CKVCFGIERA EVPSRYAEAM
210 220 230 240 250
NKYFRTWMSW YGKRYGEYKL IRSDFLTEEH REKINQATIV FVNNFAFGPA
260 270 280 290 300
VDHQLKERFA DLKDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP
310 320 330 340 350
MKGSVSWTGK PVSYYLHRID RTKLERYFQR MKKPQLKNGD DNDNSRSARE
360 370 380 390 400
KAKRDLSKQL GSSSDSDYDD QDSNYGPTTR KAWSDYCSTK GKSSQSEEEG
410 420 430 440 450
NNKNGKRQPK KLRRKIQRGK NQANGEKAQK TGPKSRRGRV KKGGKPKKTI
460 470 480 490 500
KINGLDLLHN ETLLSTSPQA IGKKLPPAPG CVDQQLTALS TELVHNELDI
510 520 530 540 550
PQAPASTPYG LQILLDMFRA QYMQMLNQMK QPTYKTSVEN HIKQEKERNK
560 570 580 590 600
KLQNRAAQLE KQIKVLIDDS VALLKARMSE LGINATSPVD LLAKAKEIVC
610 620 630 640 650
RHKELQAKAS KLQGQVASLE QEQNNLVIQR QQEIVEKYNG RDTCHDLSPI
660 670 680 690 700
ATQEYILREI SSTLAHRKKL HNQVSRLEGE LLSLEKANEE RKQAQALATR
710 720 730 740 750
QQQTPSTKSS RKSREYRARS QDWPDVPDIA KIEEQNPEIL AQKILETGRK
760 770 780 790 800
IEASKMSANC RKINLVRNNM PAPLPVPKRQ KTSYSLPPTQ SSATRAQEPP
810 820 830 840 850
RLADFEDRLK SIITSALNED QQNRNRAQSA YQQQQNYVNF QNDKHKFAKY
860 870 880 890 900
NRCETVVKQN EERSFAQQEG LAGMMESYRT EVPKVSPHVA RQVAPEQPDY
910 920 930 940 950
TQVSPAKLAL RRHLSQEKLA AQHHSFSSSD GIVATRTIGD LMSGEIERTL
960 970 980 990 1000
EISNQSIINA AVDMSDIQGT TTLTSRSVVN VNLPPRPERV KVNNETKKAE
1010 1020 1030 1040 1050
PMRQVYSPIS RPSSTEGTTT PSQLNCLRTT VSGLEGLAYT PLPRADIRPY
1060 1070 1080 1090 1100
HESYFTDVKP PIEGEIRGNF VAEGLAASLQ ARVLSGPQIK EEVDVYDRRS
1110 1120 1130 1140 1150
CVQPNVLYQD HNGSTIKSEG VSDCQYKRES PIIQGPIRNS LKRRLVDEQE
1160 1170 1180 1190 1200
PARVRKCNEE DADVEEEGEE SKWQDRISSG FDRLVAFAST ELDKRRRSTE
1210 1220 1230 1240 1250
GSDSCNTSPD SGIGHGDLPP SSLTVSTPAK QALKLNPNSK PTLFKMPNKI
1260 1270 1280 1290 1300
YLESPPLIGE SGNDESGPPR TPSPSSLISV PLNYSPEPPN EKSQPRLNPA
1310 1320 1330 1340
LLKYQREDKK VKPDQHYKKK FYYREQWRDD SWQNRDHDRY CSWKN
Length:1,345
Mass (Da):152,309
Last modified:August 10, 2010 - v1
Checksum:i58A93A20557ED398
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000276 Genomic DNA. Translation: EFA11417.1.

Genome annotation databases

EnsemblMetazoaiTC013593-RA; TC013593-PA; TC013593.
KEGGitca:660658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000276 Genomic DNA. Translation: EFA11417.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TC013593-RA ; TC013593-PA ; TC013593 .
KEGGi tca:660658.

Phylogenomic databases

InParanoidi D6W734.
KOi K11427.
OMAi VYSPISR.
OrthoDBi EOG7W6WJV.
PhylomeDBi D6W734.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the model beetle and pest Tribolium castaneum."
    Tribolium Genome Sequencing Consortium
    Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
    , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
    Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Georgia GA2Imported.
  2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
    Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
    Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: Georgia GA2Imported.

Entry informationi

Entry nameiD6W734_TRICA
AccessioniPrimary (citable) accession number: D6W734
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3