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D6W734

- D6W734_TRICA

UniProt

D6W734 - D6W734_TRICA

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
TcasGA2_TC013593
Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:TcasGA2_TC013593Imported
OrganismiTribolium castaneum (Red flour beetle)
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
ProteomesiUP000007266: Linkage group 1

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OMAiVYSPISR.
OrthoDBiEOG7W6WJV.
PhylomeDBiD6W734.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6W734-1 [UniParc]FASTAAdd to Basket

« Hide

MCALELKLHS PAGAEPVLYT WPLTSGRGND KHDGALEIVE TIRWVCEDLP     50
ELKLPLENNI LCDYDTKDYE SMKNLCDRFN RAIDSVVALE KGTSLIAQRL 100
NKYPSRGLLR HILQQTYNAA VTDPEKLNQY EPFSPEVYGE TSYDLVCQMI 150
DQIDVTSDDV FIDLGSGVGQ VVLQMAAATP CKVCFGIERA EVPSRYAEAM 200
NKYFRTWMSW YGKRYGEYKL IRSDFLTEEH REKINQATIV FVNNFAFGPA 250
VDHQLKERFA DLKDGARIVS SKSFCPLNFR ITDRNLSDIG TIMHVSEMTP 300
MKGSVSWTGK PVSYYLHRID RTKLERYFQR MKKPQLKNGD DNDNSRSARE 350
KAKRDLSKQL GSSSDSDYDD QDSNYGPTTR KAWSDYCSTK GKSSQSEEEG 400
NNKNGKRQPK KLRRKIQRGK NQANGEKAQK TGPKSRRGRV KKGGKPKKTI 450
KINGLDLLHN ETLLSTSPQA IGKKLPPAPG CVDQQLTALS TELVHNELDI 500
PQAPASTPYG LQILLDMFRA QYMQMLNQMK QPTYKTSVEN HIKQEKERNK 550
KLQNRAAQLE KQIKVLIDDS VALLKARMSE LGINATSPVD LLAKAKEIVC 600
RHKELQAKAS KLQGQVASLE QEQNNLVIQR QQEIVEKYNG RDTCHDLSPI 650
ATQEYILREI SSTLAHRKKL HNQVSRLEGE LLSLEKANEE RKQAQALATR 700
QQQTPSTKSS RKSREYRARS QDWPDVPDIA KIEEQNPEIL AQKILETGRK 750
IEASKMSANC RKINLVRNNM PAPLPVPKRQ KTSYSLPPTQ SSATRAQEPP 800
RLADFEDRLK SIITSALNED QQNRNRAQSA YQQQQNYVNF QNDKHKFAKY 850
NRCETVVKQN EERSFAQQEG LAGMMESYRT EVPKVSPHVA RQVAPEQPDY 900
TQVSPAKLAL RRHLSQEKLA AQHHSFSSSD GIVATRTIGD LMSGEIERTL 950
EISNQSIINA AVDMSDIQGT TTLTSRSVVN VNLPPRPERV KVNNETKKAE 1000
PMRQVYSPIS RPSSTEGTTT PSQLNCLRTT VSGLEGLAYT PLPRADIRPY 1050
HESYFTDVKP PIEGEIRGNF VAEGLAASLQ ARVLSGPQIK EEVDVYDRRS 1100
CVQPNVLYQD HNGSTIKSEG VSDCQYKRES PIIQGPIRNS LKRRLVDEQE 1150
PARVRKCNEE DADVEEEGEE SKWQDRISSG FDRLVAFAST ELDKRRRSTE 1200
GSDSCNTSPD SGIGHGDLPP SSLTVSTPAK QALKLNPNSK PTLFKMPNKI 1250
YLESPPLIGE SGNDESGPPR TPSPSSLISV PLNYSPEPPN EKSQPRLNPA 1300
LLKYQREDKK VKPDQHYKKK FYYREQWRDD SWQNRDHDRY CSWKN 1345
Length:1,345
Mass (Da):152,309
Last modified:August 10, 2010 - v1
Checksum:i58A93A20557ED398
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000276 Genomic DNA. Translation: EFA11417.1.

Genome annotation databases

EnsemblMetazoaiTCOGS2:TC013593-RA; TCOGS2:TC013593-PA; TCOGS2:TC013593.
KEGGitca:660658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000276 Genomic DNA. Translation: EFA11417.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai TCOGS2:TC013593-RA ; TCOGS2:TC013593-PA ; TCOGS2:TC013593 .
KEGGi tca:660658.

Phylogenomic databases

KOi K11427.
OMAi VYSPISR.
OrthoDBi EOG7W6WJV.
PhylomeDBi D6W734.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the model beetle and pest Tribolium castaneum."
    Tribolium Genome Sequencing Consortium
    Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R., Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S., Schroder R., Tautz D.
    , Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L., Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y., Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G., Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V., Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M., Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W., Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.
    Nature 452:949-955(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Georgia GA2Imported.
  2. "BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum."
    Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W., Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.
    Nucleic Acids Res. 38:D437-D442(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: Georgia GA2Imported.

Entry informationi

Entry nameiD6W734_TRICA
AccessioniPrimary (citable) accession number: D6W734
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi