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Protein

tRNA-dihydrouridine synthase

Gene

DUS3L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61Proton donorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processtRNA processingUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine synthaseUniRule annotation (EC:1.3.1.-UniRule annotation)
Gene namesi
Name:DUS3LImported
ORF Names:hCG_201507Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Family & Domainsi

Sequence similaritiesi

Belongs to the dus family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2333. Eukaryota.
COG0042. LUCA.
HOGENOMiHOG000240610.

Family and domain databases

CDDicd02801. DUS_like_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR035587. DUS-like_FMN-bd.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
PANTHERiPTHR11082. PTHR11082. 1 hit.
PfamiView protein in Pfam
PF01207. Dus. 1 hit.
PIRSFiPIRSF006621. Dus. 1 hit.
PROSITEiView protein in PROSITE
PS01136. UPF0034. 1 hit.

Sequencei

Sequence statusi: Complete.

D6W636-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVCTNLLQG QMSEWALLKR HQCEDIFGVQ LEGAFPDTMT KCAELLSRTV
60 70 80 90 100
EVDFVDINVG CPIDLVYKKG GGCALMNRST KFQQIVRGMN QVLDVPLTVK
110 120 130 140 150
IRTGVQERVN LAHRLLPELR DWGVALVTLH GRSREQRYTK LADWQYIEEC
160 170 180 190 200
VQAASPMPLF GNGDILSFED ANRAMQTGVT GIMIARGALL KPWLFTEIKE
210 220 230 240 250
QRHWDISSSE RLDILRDFTN YGLEHWGSDT QGVEKTRRFL LEWLSFLCRY
260 270 280 290 300
VPVGLLERLP QRINERPPYY LGRDYLETLM ASQKAADWIR ISEMLLGPVP
310
PSFAFLPKHK ANAYK
Length:315
Mass (Da):36,049
Last modified:August 10, 2010 - v1
Checksum:iF22D78B2AEBE55A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471139 Genomic DNA. Translation: EAW69141.1.
CH471139 Genomic DNA. Translation: EAW69142.1.
UniGeneiHs.284297.

Similar proteinsi

Entry informationi

Entry nameiD6W636_HUMAN
AccessioniPrimary (citable) accession number: D6W636
Entry historyiIntegrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: August 30, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.