D6W5L6 (D6W5L6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pulmonary surfactant-associated protein B Ensembl ENSP00000386346 Ensembl ENSP00000377409

Submitted name:
Surfactant, pulmonary-associated protein B, isoform CRA_a EMBL EAW99488.1

Gene names

Name:	SFTPB Ensembl ENSP00000386346 EMBL EAW99488.1 Ensembl ENSP00000377409
ORF Names:	hCG_34600 EMBL EAW99488.1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
PTM	Disulfide bond SAAS SAAS011001
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sphingolipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	lysosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D6W5L6 [UniParc]. Last modified August 10, 2010. Version 1. Checksum: AF32E2C83D8F3E7B	FASTA	393	43,347
	10 20 30 40 50 60 MHQAGYPGCR GAMAESHLLQ WLLLLLPTLC GPGTAAWTTS SLACAQGPEF WCQSLEQALQ 70 80 90 100 110 120 CRALGHCLQE VWGHVGADDL CQECEDIVHI LNKMAKEAIF QDTMRKFLEQ ECNVLPLKLL 130 140 150 160 170 180 MPQCNQVLDD YFPLVIDYFQ NQTDSNGICM HLGLCKSRQP EPEQEPGMSD PLPKPLRDPL 190 200 210 220 230 240 PDPLLDKLVL PVLPGALQAR PGPHTQDLSE QQFPIPLPYC WLCRALIKRI QAMIPKGALA 250 260 270 280 290 300 VAVAQVCRVV PLVAGGICQC LAERYSVILL DTLLGRMLPQ LVCRLVLRCS MDDSAGPRSP 310 320 330 340 350 360 TGEWLPRDSE CHLCMSVTTQ AGNSSEQAIP QAMLQACVGS WLDREKCKQF VEQHTPQLLT 370 380 390 LVPRGWDAHT TCQALGVCGT MSSPLQCIHS PDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of the human genome." Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H. , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X. Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (AUG-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012454 Genomic DNA. No translation available. CH471053 Genomic DNA. Translation: EAW99487.1. CH471053 Genomic DNA. Translation: EAW99488.1. CH471053 Genomic DNA. Translation: EAW99489.1.
IPI	IPI01013812.
RefSeq	NP_000533.3. NM_000542.3. NP_942140.2. NM_198843.2.
UniGene	Hs.512690.
3D structure databases
SMR	D6W5L6. Positions 81-157.
ModBase	Search...
Proteomic databases
PRIDE	D6W5L6.
Protocols and materials databases
DNASU	6439.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393822; ENSP00000377409; ENSG00000168878. ENST00000409383; ENSP00000386346; ENSG00000168878.
GeneID	6439.
KEGG	hsa:6439.
UCSC	uc002sqh.3. human.
Organism-specific databases
CTD	6439.
HGNC	HGNC:10801. SFTPB.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000115745.
OMA	CWLCRTL.
Gene expression databases
ArrayExpress	D6W5L6.
Family and domain databases
Gene3D	1.10.225.10. 3 hits.
InterPro	IPR003119. SapA. IPR007856. SapB_1. IPR008138. SapB_2. IPR008373. Saposin. IPR011001. Saposin-like. IPR008139. SaposinB. [Graphical view]
Pfam	PF02199. SapA. 1 hit. PF05184. SapB_1. 1 hit. PF03489. SapB_2. 2 hits. [Graphical view]
PRINTS	PR01797. SAPOSIN.
SMART	SM00162. SAPA. 1 hit. SM00741. SapB. 3 hits. [Graphical view]
SUPFAM	SSF47862. Saposin_like. 3 hits.
PROSITE	PS51110. SAP_A. 1 hit. PS50015. SAP_B. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SFTPB. human.
GenomeRNAi	6439.
NextBio	25021.

Entry information

Entry name

D6W5L6_HUMAN

Accession

Primary (citable) accession number: D6W5L6

Entry history

Integrated into UniProtKB/TrEMBL:	August 10, 2010
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.