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D6W5L6

- D6W5L6_HUMAN

UniProt

D6W5L6 - D6W5L6_HUMAN

Protein
Submitted name:

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. sphingolipid metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pulmonary surfactant-associated protein BImported
    Submitted name:
    Surfactant, pulmonary-associated protein B, isoform CRA_aImported
    Gene namesi
    Name:SFTPBImported
    ORF Names:hCG_34600Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10801. SFTPB.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    SMRiD6W5L6. Positions 81-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000115745.
    OMAiCWLCRTL.
    PhylomeDBiD6W5L6.
    TreeFamiTF316942.

    Family and domain databases

    Gene3Di1.10.225.10. 3 hits.
    InterProiIPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view]
    PRINTSiPR01797. SAPOSIN.
    SMARTiSM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 3 hits.
    PROSITEiPS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D6W5L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQAGYPGCR GAMAESHLLQ WLLLLLPTLC GPGTAAWTTS SLACAQGPEF    50
    WCQSLEQALQ CRALGHCLQE VWGHVGADDL CQECEDIVHI LNKMAKEAIF 100
    QDTMRKFLEQ ECNVLPLKLL MPQCNQVLDD YFPLVIDYFQ NQTDSNGICM 150
    HLGLCKSRQP EPEQEPGMSD PLPKPLRDPL PDPLLDKLVL PVLPGALQAR 200
    PGPHTQDLSE QQFPIPLPYC WLCRALIKRI QAMIPKGALA VAVAQVCRVV 250
    PLVAGGICQC LAERYSVILL DTLLGRMLPQ LVCRLVLRCS MDDSAGPRSP 300
    TGEWLPRDSE CHLCMSVTTQ AGNSSEQAIP QAMLQACVGS WLDREKCKQF 350
    VEQHTPQLLT LVPRGWDAHT TCQALGVCGT MSSPLQCIHS PDL 393
    Length:393
    Mass (Da):43,347
    Last modified:August 10, 2010 - v1
    Checksum:iAF32E2C83D8F3E7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012454 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99487.1.
    CH471053 Genomic DNA. Translation: EAW99488.1.
    CH471053 Genomic DNA. Translation: EAW99489.1.
    RefSeqiNP_000533.3. NM_000542.3.
    NP_942140.2. NM_198843.2.
    XP_005264544.1. XM_005264487.1.
    UniGeneiHs.512690.

    Genome annotation databases

    EnsembliENST00000393822; ENSP00000377409; ENSG00000168878.
    ENST00000409383; ENSP00000386346; ENSG00000168878.
    GeneIDi6439.
    KEGGihsa:6439.
    UCSCiuc002sqh.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012454 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAW99487.1 .
    CH471053 Genomic DNA. Translation: EAW99488.1 .
    CH471053 Genomic DNA. Translation: EAW99489.1 .
    RefSeqi NP_000533.3. NM_000542.3.
    NP_942140.2. NM_198843.2.
    XP_005264544.1. XM_005264487.1.
    UniGenei Hs.512690.

    3D structure databases

    SMRi D6W5L6. Positions 81-157.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 6439.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393822 ; ENSP00000377409 ; ENSG00000168878 .
    ENST00000409383 ; ENSP00000386346 ; ENSG00000168878 .
    GeneIDi 6439.
    KEGGi hsa:6439.
    UCSCi uc002sqh.3. human.

    Organism-specific databases

    CTDi 6439.
    HGNCi HGNC:10801. SFTPB.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000115745.
    OMAi CWLCRTL.
    PhylomeDBi D6W5L6.
    TreeFami TF316942.

    Miscellaneous databases

    ChiTaRSi SFTPB. human.
    GenomeRNAii 6439.
    NextBioi 25021.

    Family and domain databases

    Gene3Di 1.10.225.10. 3 hits.
    InterProi IPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF02199. SapA. 1 hit.
    PF05184. SapB_1. 1 hit.
    PF03489. SapB_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01797. SAPOSIN.
    SMARTi SM00162. SAPA. 1 hit.
    SM00741. SapB. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 3 hits.
    PROSITEi PS51110. SAP_A. 1 hit.
    PS50015. SAP_B. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE.
    4. Ensembl
      Submitted (AUG-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiD6W5L6_HUMAN
    AccessioniPrimary (citable) accession number: D6W5L6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 10, 2010
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3