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Protein
Submitted name:

Spectrin, beta, non-erythrocytic 1, isoform CRA_b

Gene

SPTBN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Spectrin, beta, non-erythrocytic 1, isoform CRA_bImported
Gene namesi
Name:SPTBN1Imported
ORF Names:hCG_17370Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiD6W5C0.

Expressioni

Gene expression databases

BgeeiENSG00000115306.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349259.

Structurei

3D structure databases

SMRiD6W5C0. Positions 87-194, 2114-2219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7272Actin-bindingInterPro annotationAdd
BLAST
Domaini87 – 189103Actin-bindingInterPro annotationAdd
BLAST
Domaini2111 – 2221111PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili371 – 40535Sequence analysisAdd
BLAST
Coiled coili905 – 94642Sequence analysisAdd
BLAST
Coiled coili1011 – 103828Sequence analysisAdd
BLAST
Coiled coili1336 – 137035Sequence analysisAdd
BLAST
Coiled coili1767 – 179428Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR016343. Spectrin_bsu.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 17 hits.
[Graphical view]
PIRSFiPIRSF002297. Spectrin_beta_subunit. 1 hit.
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D6W5C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIKLLEVLS GERLPKPTKG RMRIHCLENV DKALQFLKEQ RVHLENMGSH
60 70 80 90 100
DIVDGNHRLT LGLIWTIILR FQIQDISVET EDNKEKKSAK DALLLWCQMK
110 120 130 140 150
TAGYPNVNIH NFTTSWRDGM AFNALIHKHR PDLIDFDKLK KSNAHYNLQN
160 170 180 190 200
AFNLAEQHLG LTKLLDPEDI SVDHPDEKSI ITYVVTYYHY FSKMKALAVE
210 220 230 240 250
GKRIGKVLDN AIETEKMIEK YESLASDLLE WIEQTIIILN NRKFANSLVG
260 270 280 290 300
VQQQLQAFNT YRTVEKPPKF TEKGNLEVLL FTIQSKMRAN NQKVYMPREG
310 320 330 340 350
KLISDINKAW ERLEKAEHER ELALRNELIR QEKLEQLARR FDRKAAMRET
360 370 380 390 400
WLSENQRLVS QDNFGFDLPA VEAATKKHEA IETDIAAYEE RVQAVVAVAR
410 420 430 440 450
ELEAENYHDI KRITARKDNV IRLWEYLLEL LRARRQRLEM NLGLQKIFQE
460 470 480 490 500
MLYIMDWMDE MKVLVLSQDY GKHLLGVEDL LQKHTLVEAD IGIQAERVRG
510 520 530 540 550
VNASAQKFAT DGEGYKPCDP QVIRDRVAHM EFCYQELCQL AAERRARLEE
560 570 580 590 600
SRRLWKFFWE MAEEEGWIRE KEKILSSDDY GKDLTSVMRL LSKHRAFEDE
610 620 630 640 650
MSGRSGHFEQ AIKEGEDMIA EEHFGSEKIR ERIIYIREQW ANLEQLSAIR
660 670 680 690 700
KKRLEEASLL HQFQADADDI DAWMLDILKI VSSSDVGHDE YSTQSLVKKH
710 720 730 740 750
KDVAEEIANY RPTLDTLHEQ ASALPQEHAE SPDVRGRLSG IEERYKEVAE
760 770 780 790 800
LTRLRKQALQ DTLALYKMFS EADACELWID EKEQWLNNMQ IPEKLEDLEV
810 820 830 840 850
IQHRFESLEP EMNNQASRVA VVNQIARQLM HSGHPSEKEI KAQQDKLNTR
860 870 880 890 900
WSQFRELVDR KKDALLSALS IQNYHLECNE TKSWIREKTK VIESTQDLGN
910 920 930 940 950
DLAGVMALQR KLTGMERDLV AIEAKLSDLQ KEAEKLESEH PDQAQAILSR
960 970 980 990 1000
LAEISDVWEE MKTTLKNREA SLGEASKLQQ FLRDLDDFQS WLSRTQTAIA
1010 1020 1030 1040 1050
SEDMPNTLTE AEKLLTQHEN IKNEIDNYEE DYQKMRDMGE MVTQGQTDAQ
1060 1070 1080 1090 1100
YMFLRQRLQA LDTGWNELHK MWENRQNLLS QSHAYQQFLR DTKQAEAFLN
1110 1120 1130 1140 1150
NQEYVLAHTE MPTTLEGAEA AIKKQEDFMT TMDANEEKIN AVVETGRRLV
1160 1170 1180 1190 1200
SDGNINSDRI QEKVDSIDDR HRKNRETASE LLMRLKDNRD LQKFLQDCQE
1210 1220 1230 1240 1250
LSLWINEKML TAQDMSYDEA RNLHSKWLKH QAFMAELASN KEWLDKIEKE
1260 1270 1280 1290 1300
GMQLISEKPE TEAVVKEKLT GLHKMWEVLE STTQTKAQRL FDANKAELFT
1310 1320 1330 1340 1350
QSCADLDKWL HGLESQIQSD DYGKDLTSVN ILLKKQQMLE NQMEVRKKEI
1360 1370 1380 1390 1400
EELQSQAQAL SQEGKSTDEV DSKRLTVQTK FMELLEPLNE RKHNLLASKE
1410 1420 1430 1440 1450
IHQFNRDVED EILWVGERMP LATSTDHGHN LQTVQLLIKK NQTLQKEIQG
1460 1470 1480 1490 1500
HQPRIDDIFE RSQNIVTDSS SLSAEAIRQR LADLKQLWGL LIEETEKRHR
1510 1520 1530 1540 1550
RLEEAHRAQQ YYFDAAEAEA WMSEQELYMM SEEKAKDEQS AVSMLKKHQI
1560 1570 1580 1590 1600
LEQAVEDYAE TVHQLSKTSR ALVADSHPES ERISMRQSKV DKLYAGLKDL
1610 1620 1630 1640 1650
AEERRGKLDE RHRLFQLNRE VDDLEQWIAE REVVAGSHEL GQDYEHVTML
1660 1670 1680 1690 1700
QERFREFARD TGNIGQERVD TVNHLADELI NSGHSDAATI AEWKDGLNEA
1710 1720 1730 1740 1750
WADLLELIDT RTQILAASYE LHKFYHDAKE IFGRIQDKHK KLPEELGRDQ
1760 1770 1780 1790 1800
NTVETLQRMH TTFEHDIQAL GTQVRQLQED AARLQAAYAG DKADDIQKRE
1810 1820 1830 1840 1850
NEVLEAWKSL LDACESRRVR LVDTGDKFRF FSMVRDLMLW MEDVIRQIEA
1860 1870 1880 1890 1900
QEKPRDVSSV ELLMNNHQGI KAEIDARNDS FTTCIELGKS LLARKHYASE
1910 1920 1930 1940 1950
EIKEKLLQLT EKRKEMIDKW EDRWEWLRLI LEVHQFSRDA SVAEAWLLGQ
1960 1970 1980 1990 2000
EPYLSSREIG QSVDEVEKLI KRHEAFEKSA ATWDERFSAL ERLTTLELLE
2010 2020 2030 2040 2050
VRRQQEEEER KRRPPSPEPS TKVSEEAESQ QQWDTSKGEQ VSQNGLPAEQ
2060 2070 2080 2090 2100
GSPRMAETVD TSEMVNGATE QRTSSKESSP IPSPTSDRKA KTALPAQSAA
2110 2120 2130 2140 2150
TLPARTQETP SAQMEGFLNR KHEWEAHNKK ASSRSWHNVY CVINNQEMGF
2160 2170 2180 2190 2200
YKDAKTAASG IPYHSEVPVS LKEAVCEVAL DYKKKKHVFK LRLNDGNEYL
2210 2220 2230 2240 2250
FQAKDDEEMN TWIQAISSAI SSDKHEVSAS TQSTPASSRA QTLPTSVVTI
2260 2270
TSESSPGKRE KDKEKDKEKR FSLFGKKK
Length:2,278
Mass (Da):264,440
Last modified:August 10, 2010 - v1
Checksum:iFEF4448A096294BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00138.1.
CH471053 Genomic DNA. Translation: EAX00145.1.
UniGeneiHs.503178.
Hs.705692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00138.1.
CH471053 Genomic DNA. Translation: EAX00145.1.
UniGeneiHs.503178.
Hs.705692.

3D structure databases

SMRiD6W5C0. Positions 87-194, 2114-2219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349259.

Proteomic databases

PeptideAtlasiD6W5C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.

Miscellaneous databases

ChiTaRSiSPTBN1. human.

Gene expression databases

BgeeiENSG00000115306.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR016343. Spectrin_bsu.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 17 hits.
[Graphical view]
PIRSFiPIRSF002297. Spectrin_beta_subunit. 1 hit.
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD6W5C0_HUMAN
AccessioniPrimary (citable) accession number: D6W5C0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 10, 2010
Last sequence update: August 10, 2010
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.