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Protein

Truncated non-functional calcium-binding mitochondrial carrier SAL1-1

Gene

SAL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier.1 Publication

Miscellaneous

Present with 1170 molecules/cell in log phase SD medium.1 Publication

Caution

Strain S288c has a frameshift in position 403, which disrupts the gene coding for this protein and produces the non-functional allele sal1-1. A full-length functional allele can be found in strain CG379 (AC P0CI40).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi59 – 701Add BLAST12
Calcium bindingi93 – 1042Add BLAST12
Calcium bindingi155 – 1663Add BLAST12

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: SGD
  • calcium ion binding Source: SGD

GO - Biological processi

  • ADP transport Source: SGD
  • ATP transport Source: SGD
  • mitochondrial transport Source: SGD

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33112-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Truncated non-functional calcium-binding mitochondrial carrier SAL1-1
Alternative name(s):
Suppressor of AAC2 lethality
Gene namesi
Name:SAL1
Ordered Locus Names:YNL083W
ORF Names:N2312
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL083W
SGDiS000005027 SAL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 248Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei307 – 326Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei355 – 368Helical; Name=3Sequence analysisAdd BLAST14
Transmembranei409 – 428Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei458 – 475Helical; Name=5Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004022771 – 494Truncated non-functional calcium-binding mitochondrial carrier SAL1-1Add BLAST494

Proteomic databases

PaxDbiD6W196
PRIDEiD6W196

PTM databases

iPTMnetiD6W196

Interactioni

Protein-protein interaction databases

BioGridi35740, 52 interactors
STRINGi4932.YNL083W

Structurei

3D structure databases

ProteinModelPortaliD6W196
SMRiD6W196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini120 – 155EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini156 – 191EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati225 – 332Solcar 1Add BLAST108
Repeati345 – 434Solcar 2Add BLAST90
Repeati452 – 494Solcar 3; truncatedAdd BLAST43

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD6W196
KOiK14684
OrthoDBiEOG092C2RR5

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
PF00153 Mito_carr, 2 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

D6W196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN
60 70 80 90 100
DEAIKMLFTA MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI
110 120 130 140 150
GINEINRYLS DLDNQSICNN ELNHELSNEK VNKFSRFFEW AFPKRKANIA
160 170 180 190 200
LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ WRDFLLLVPR KQGSRLHTAY
210 220 230 240 250
SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI SRTCTAPFDR
260 270 280 290 300
LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG
310 320 330 340 350
IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST
360 370 380 390 400
YIAGGLAGMA AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE
410 420 430 440 450
GGGQIILQRC HSRYSGHISL CCIRFGDFFC LKKMVYCQTG KDPEPTTRSG
460 470 480 490
HSKQPGCTSN GCIQWNCRSF CCLSNQSFKN KTTSPRNICT SLCV
Length:494
Mass (Da):55,715
Last modified:November 30, 2010 - v2
Checksum:i0AB408E1CED63946
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131V → M in DAA10462 (PubMed:9169873).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89016 Genomic DNA Translation: CAA61427.1
Z71359 Genomic DNA Translation: CAA95958.1
AY268134 Genomic DNA Translation: AAR26280.1
BK006947 Genomic DNA Translation: DAA10462.2
PIRiS57539
RefSeqiNP_014316.3, NM_001182921.1

Genome annotation databases

GeneIDi855641
KEGGisce:YNL083W

Similar proteinsi

Entry informationi

Entry nameiCMC1_YEAST
AccessioniPrimary (citable) accession number: D6W196
Secondary accession number(s): P48233
, Q45TY5, Q6WV05, Q96US1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: February 28, 2018
This is version 61 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health