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Protein

Pheromone alpha factor receptor

Gene

STE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the peptide pheromone alpha factor, the mating factor of yeast.

GO - Molecular functioni

  • mating-type alpha-factor pheromone receptor activity Source: SGD
  • pheromone binding Source: GO_Central

GO - Biological processi

  • cell projection assembly Source: SGD
  • cytogamy Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • positive regulation of conjugation with cellular fusion Source: GO_Central
  • protein homooligomerization Source: SGD
  • receptor transactivation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-30434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone alpha factor receptor
Gene namesi
Name:STE2
Ordered Locus Names:YFL026W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL026W.
SGDiS000001868. STE2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7323HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10223HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15523HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18423HelicalSequence analysisAdd
BLAST
Transmembranei209 – 23123HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26623HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Pheromone alpha factor receptorPRO_0000195068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)1 Publication
Glycosylationi32 – 321N-linked (GlcNAc...)1 Publication
Modified residuei310 – 3101PhosphoserineCombined sources
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei329 – 3291PhosphothreonineCombined sources
Modified residuei331 – 3311PhosphoserineCombined sources
Modified residuei360 – 3601PhosphoserineCombined sources
Modified residuei363 – 3631PhosphothreonineCombined sources
Modified residuei366 – 3661PhosphoserineCombined sources
Cross-linki374 – 374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei382 – 3821PhosphothreonineCombined sources
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei386 – 3861PhosphoserineCombined sources
Cross-linki400 – 400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei411 – 4111PhosphothreonineCombined sources
Modified residuei414 – 4141PhosphothreonineCombined sources
Cross-linki422 – 422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiD6VTK4.

PTM databases

iPTMnetiD6VTK4.

Interactioni

Protein-protein interaction databases

BioGridi31120. 41 interactions.
IntActiD6VTK4. 1 interaction.

Structurei

Secondary structure

1
431
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi39 – 7234Combined sources
Helixi80 – 10627Combined sources
Helixi256 – 2649Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PJDNMR-A253-269[»]
2K9PNMR-A31-110[»]
ProteinModelPortaliD6VTK4.
SMRiD6VTK4. Positions 31-110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD6VTK4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD6VTK4.
KOiK11213.
OMAiFHILLIM.
OrthoDBiEOG092C31CN.

Family and domain databases

Gene3Di1.10.287.920. 1 hit.
InterProiIPR000366. GPCR_STE2.
IPR027458. STE2_TM1-TM2.
[Graphical view]
PfamiPF02116. STE2. 1 hit.
[Graphical view]
PRINTSiPR00250. GPCRSTE2.

Sequencei

Sequence statusi: Complete.

D6VTK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT
60 70 80 90 100
QAIMFGVRCG AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK
110 120 130 140 150
YLLSNYSSVT YALTGFPQFI SRGDVHVYGA TNIIQVLLVA SIETSLVFQI
160 170 180 190 200
KVIFTGDNFK RIGLMLTSIS FTLGIATVTM YFVSAVKGMI VTYNDVSATQ
210 220 230 240 250
DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ FDSFHILLIM
260 270 280 290 300
SCQSLLVPSI IFILAYSLKP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN
310 320 330 340 350
NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR
360 370 380 390 400
RKETTSDKHS ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK
410 420 430
EGEVEPVDMY TPDTAADEEA RKFWTEDNNN L
Length:431
Mass (Da):47,849
Last modified:September 21, 2011 - v2
Checksum:i011F604DC2A6907E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691K → E in BAA09212 (PubMed:7670463).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03010 Genomic DNA. Translation: CAA26794.1.
M24335 Genomic DNA. Translation: AAA35112.1.
AJ585736 Genomic DNA. Translation: CAE52256.1.
D50617 Genomic DNA. Translation: BAA09212.1.
AY693134 Genomic DNA. Translation: AAT93153.1.
BK006940 Genomic DNA. Translation: DAA12414.2.
PIRiS56228.
RefSeqiNP_116627.2. NM_001179940.2.

Genome annotation databases

EnsemblFungiiBAA09212; BAA09212; BAA09212.
YFL026W; YFL026W; YFL026W.
GeneIDi850518.
KEGGisce:YFL026W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03010 Genomic DNA. Translation: CAA26794.1.
M24335 Genomic DNA. Translation: AAA35112.1.
AJ585736 Genomic DNA. Translation: CAE52256.1.
D50617 Genomic DNA. Translation: BAA09212.1.
AY693134 Genomic DNA. Translation: AAT93153.1.
BK006940 Genomic DNA. Translation: DAA12414.2.
PIRiS56228.
RefSeqiNP_116627.2. NM_001179940.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PJDNMR-A253-269[»]
2K9PNMR-A31-110[»]
ProteinModelPortaliD6VTK4.
SMRiD6VTK4. Positions 31-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31120. 41 interactions.
IntActiD6VTK4. 1 interaction.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiD6VTK4.

Proteomic databases

MaxQBiD6VTK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09212; BAA09212; BAA09212.
YFL026W; YFL026W; YFL026W.
GeneIDi850518.
KEGGisce:YFL026W.

Organism-specific databases

EuPathDBiFungiDB:YFL026W.
SGDiS000001868. STE2.

Phylogenomic databases

InParanoidiD6VTK4.
KOiK11213.
OMAiFHILLIM.
OrthoDBiEOG092C31CN.

Enzyme and pathway databases

BioCyciYEAST:G3O-30434-MONOMER.

Miscellaneous databases

EvolutionaryTraceiD6VTK4.
PROiD6VTK4.

Family and domain databases

Gene3Di1.10.287.920. 1 hit.
InterProiIPR000366. GPCR_STE2.
IPR027458. STE2_TM1-TM2.
[Graphical view]
PfamiPF02116. STE2. 1 hit.
[Graphical view]
PRINTSiPR00250. GPCRSTE2.
ProtoNetiSearch...

Entry informationi

Entry nameiSTE2_YEAST
AccessioniPrimary (citable) accession number: D6VTK4
Secondary accession number(s): P06842
, Q70D63, Q70D65, Q70D69, Q70D73, Q70D74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

N-glycosylation may be involved in the sorting process for misfolded STE2 protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.