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Protein

Pheromone alpha factor receptor

Gene

STE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the peptide pheromone alpha factor, the mating factor of yeast.

GO - Molecular functioni

  • mating-type alpha-factor pheromone receptor activity Source: SGD
  • pheromone binding Source: GO_Central

GO - Biological processi

  • cell projection assembly Source: SGD
  • cytogamy Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • positive regulation of conjugation with cellular fusion Source: GO_Central
  • protein homooligomerization Source: SGD
  • receptor transactivation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Enzyme and pathway databases

BioCyciYEAST:G3O-30434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone alpha factor receptor
Gene namesi
Name:STE2
Ordered Locus Names:YFL026W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL026W.
SGDiS000001868. STE2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 73HelicalSequence analysisAdd BLAST23
Transmembranei80 – 102HelicalSequence analysisAdd BLAST23
Transmembranei133 – 155HelicalSequence analysisAdd BLAST23
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Transmembranei244 – 266HelicalSequence analysisAdd BLAST23
Transmembranei276 – 298HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950681 – 431Pheromone alpha factor receptorAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)1 Publication1
Glycosylationi32N-linked (GlcNAc...)1 Publication1
Modified residuei310PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei329PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei363PhosphothreonineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei382PhosphothreonineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei411PhosphothreonineCombined sources1
Modified residuei414PhosphothreonineCombined sources1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiD6VTK4.
PRIDEiD6VTK4.

PTM databases

iPTMnetiD6VTK4.

Interactioni

Protein-protein interaction databases

BioGridi31120. 41 interactors.
IntActiD6VTK4. 1 interactor.

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 72Combined sources34
Helixi80 – 106Combined sources27
Helixi256 – 264Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PJDNMR-A253-269[»]
2K9PNMR-A31-110[»]
ProteinModelPortaliD6VTK4.
SMRiD6VTK4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD6VTK4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiD6VTK4.
KOiK11213.
OMAiFHILLIM.
OrthoDBiEOG092C31CN.

Family and domain databases

Gene3Di1.10.287.920. 1 hit.
InterProiIPR000366. GPCR_STE2.
IPR027458. STE2_TM1-TM2.
[Graphical view]
PfamiPF02116. STE2. 1 hit.
[Graphical view]
PRINTSiPR00250. GPCRSTE2.

Sequencei

Sequence statusi: Complete.

D6VTK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAPSLSN LFYDPTYNPG QSTINYTSIY GNGSTITFDE LQGLVNSTVT
60 70 80 90 100
QAIMFGVRCG AAALTLIVMW MTSRSRKTPI FIINQVSLFL IILHSALYFK
110 120 130 140 150
YLLSNYSSVT YALTGFPQFI SRGDVHVYGA TNIIQVLLVA SIETSLVFQI
160 170 180 190 200
KVIFTGDNFK RIGLMLTSIS FTLGIATVTM YFVSAVKGMI VTYNDVSATQ
210 220 230 240 250
DKYFNASTIL LASSINFMSF VLVVKLILAI RSRRFLGLKQ FDSFHILLIM
260 270 280 290 300
SCQSLLVPSI IFILAYSLKP NQGTDVLTTV ATLLAVLSLP LSSMWATAAN
310 320 330 340 350
NASKTNTITS DFTTSTDRFY PGTLSSFQTD SINNDAKSSL RSRLYDLYPR
360 370 380 390 400
RKETTSDKHS ERTFVSETAD DIEKNQFYQL PTPTSSKNTR IGPFADASYK
410 420 430
EGEVEPVDMY TPDTAADEEA RKFWTEDNNN L
Length:431
Mass (Da):47,849
Last modified:September 21, 2011 - v2
Checksum:i011F604DC2A6907E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269K → E in BAA09212 (PubMed:7670463).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03010 Genomic DNA. Translation: CAA26794.1.
M24335 Genomic DNA. Translation: AAA35112.1.
AJ585736 Genomic DNA. Translation: CAE52256.1.
D50617 Genomic DNA. Translation: BAA09212.1.
AY693134 Genomic DNA. Translation: AAT93153.1.
BK006940 Genomic DNA. Translation: DAA12414.2.
PIRiS56228.
RefSeqiNP_116627.2. NM_001179940.2.

Genome annotation databases

EnsemblFungiiBAA09212; BAA09212; BAA09212.
YFL026W; YFL026W; YFL026W.
GeneIDi850518.
KEGGisce:YFL026W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03010 Genomic DNA. Translation: CAA26794.1.
M24335 Genomic DNA. Translation: AAA35112.1.
AJ585736 Genomic DNA. Translation: CAE52256.1.
D50617 Genomic DNA. Translation: BAA09212.1.
AY693134 Genomic DNA. Translation: AAT93153.1.
BK006940 Genomic DNA. Translation: DAA12414.2.
PIRiS56228.
RefSeqiNP_116627.2. NM_001179940.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PJDNMR-A253-269[»]
2K9PNMR-A31-110[»]
ProteinModelPortaliD6VTK4.
SMRiD6VTK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31120. 41 interactors.
IntActiD6VTK4. 1 interactor.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiD6VTK4.

Proteomic databases

MaxQBiD6VTK4.
PRIDEiD6VTK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09212; BAA09212; BAA09212.
YFL026W; YFL026W; YFL026W.
GeneIDi850518.
KEGGisce:YFL026W.

Organism-specific databases

EuPathDBiFungiDB:YFL026W.
SGDiS000001868. STE2.

Phylogenomic databases

InParanoidiD6VTK4.
KOiK11213.
OMAiFHILLIM.
OrthoDBiEOG092C31CN.

Enzyme and pathway databases

BioCyciYEAST:G3O-30434-MONOMER.

Miscellaneous databases

EvolutionaryTraceiD6VTK4.
PROiD6VTK4.

Family and domain databases

Gene3Di1.10.287.920. 1 hit.
InterProiIPR000366. GPCR_STE2.
IPR027458. STE2_TM1-TM2.
[Graphical view]
PfamiPF02116. STE2. 1 hit.
[Graphical view]
PRINTSiPR00250. GPCRSTE2.
ProtoNetiSearch...

Entry informationi

Entry nameiSTE2_YEAST
AccessioniPrimary (citable) accession number: D6VTK4
Secondary accession number(s): P06842
, Q70D63, Q70D65, Q70D69, Q70D73, Q70D74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

N-glycosylation may be involved in the sorting process for misfolded STE2 protein.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.